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Murcko scaffold

Ring system with 3 rings and 26 atoms

76 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
76
With full pages
9
Scaffold SMILES

O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCCN1C(=O)C(=Cc2ccccc2)SC1=S)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 76 chemicals

(Z)-3-(4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)butanamido)benzoic acid chemical structure, C21H18N2O4S2, CAS 303792-69-0
(Z)-3-(4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)butanamido)benzoic acid
CAS 303792-69-0C21H18N2O4S2
(Z)-N-(3-Hydroxyphenyl)-4-(5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanamide chemical structure, C21H20N2O4S2, CAS 300378-19-2
(Z)-N-(3-Hydroxyphenyl)-4-(5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanamide
CAS 300378-19-2C21H20N2O4S2
N-(3-Chlorophenyl)-4-[(5Z)-5-[(4-ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamide chemical structure, C22H21ClN2O2S2, CAS 315243-08-4
N-(3-Chlorophenyl)-4-[(5Z)-5-[(4-ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamide
CAS 315243-08-4C22H21ClN2O2S2
3-({4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}amino)benzoic acid chemical structure, C23H22N2O4S2, CAS 315243-26-6
3-({4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}amino)benzoic acid
CAS 315243-26-6C23H22N2O4S2
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(3-hydroxyphenyl)butanamide chemical structure, C22H22N2O3S2, CAS 315242-94-5
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(3-hydroxyphenyl)butanamide
CAS 315242-94-5C22H22N2O3S2
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(2-methoxyphenyl)butanamide chemical structure, C23H24N2O3S2, CAS 315242-88-7
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(2-methoxyphenyl)butanamide
CAS 315242-88-7C23H24N2O3S2
N-(4-Acetylphenyl)-4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanamide chemical structure, C24H24N2O3S2, CAS 315243-24-4
N-(4-Acetylphenyl)-4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanamide
CAS 315243-24-4C24H24N2O3S2
4-[(5E)-5-[(4-Methylphenyl)methylidene]-4-oxo-2-sulfanylidene-thiazolidin-3-yl]-N-(2,4,6-trimethylphenyl)butanamide chemical structure, C24H26N2O2S2, CAS 6605-21-6
4-[(5E)-5-[(4-Methylphenyl)methylidene]-4-oxo-2-sulfanylidene-thiazolidin-3-yl]-N-(2,4,6-trimethylphenyl)butanamide
CAS 6605-21-6C24H26N2O2S2
N-(3-Chloro-4-fluorophenyl)-4-[5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanamide chemical structure, C21H18ClFN2O2S2, CAS 6613-37-2
N-(3-Chloro-4-fluorophenyl)-4-[5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanamide
CAS 6613-37-2C21H18ClFN2O2S2
4-[(5Z)-5-[(3-Methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-[2-(trifluoromethyl)phenyl]butanamide chemical structure, C22H19F3N2O3S2, CAS 394236-19-2
4-[(5Z)-5-[(3-Methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-[2-(trifluoromethyl)phenyl]butanamide
CAS 394236-19-2C22H19F3N2O3S2
N-(2,4-Dimethylphenyl)-4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanamide chemical structure, C24H26N2O2S2, CAS 315242-97-8
N-(2,4-Dimethylphenyl)-4-[(5Z)-5-(4-ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanamide
CAS 315242-97-8C24H26N2O2S2
2-[4-[(5Z)-5-[(4-Ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid chemical structure, C23H22N2O4S2, CAS 315243-25-5
2-[4-[(5Z)-5-[(4-Ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid
CAS 315243-25-5C23H22N2O4S2
4-[(5Z)-5-[(4-Ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-phenylbutanamide chemical structure, C22H22N2O2S2, CAS 315242-82-1
4-[(5Z)-5-[(4-Ethylphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-phenylbutanamide
CAS 315242-82-1C22H22N2O2S2
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(3-methoxyphenyl)butanamide chemical structure, C23H24N2O3S2, CAS 315242-89-8
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(3-methoxyphenyl)butanamide
CAS 315242-89-8C23H24N2O3S2
(Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-phenylbutanamide chemical structure, C20H18N2O2S2, CAS 303792-66-7
(Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-phenylbutanamide
CAS 303792-66-7C20H18N2O2S2
N-(4-Hydroxyphenyl)-4-[(5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamide chemical structure, C21H20N2O4S2, CAS 303792-75-8
N-(4-Hydroxyphenyl)-4-[(5Z)-5-[(4-methoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamide
CAS 303792-75-8C21H20N2O4S2
(Z)-2-(4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)butanamido)benzoic acid chemical structure, C21H18N2O4S2, CAS 300378-11-4
(Z)-2-(4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)butanamido)benzoic acid
CAS 300378-11-4C21H18N2O4S2
4-({4-[(5Z)-5-(3-Bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}amino)benzoic acid chemical structure, C21H17BrN2O4S2, CAS 315235-95-1
4-({4-[(5Z)-5-(3-Bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}amino)benzoic acid
CAS 315235-95-1C21H17BrN2O4S2
(Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-(2-hydroxyphenyl)butanamide chemical structure, C20H18N2O3S2, CAS 303792-67-8
(Z)-4-(5-Benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-N-(2-hydroxyphenyl)butanamide
CAS 303792-67-8C20H18N2O3S2
4-[(5Z)-5-Benzylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(4-hydroxyphenyl)butanamide chemical structure, C20H18N2O3S2, CAS 303792-68-9
4-[(5Z)-5-Benzylidene-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]-N-(4-hydroxyphenyl)butanamide
CAS 303792-68-9C20H18N2O3S2
4-({4-[(5Z)-5-Benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}amino)benzoic acid chemical structure, C21H18N2O4S2, CAS 303792-70-3
4-({4-[(5Z)-5-Benzylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoyl}amino)benzoic acid
CAS 303792-70-3C21H18N2O4S2
(Z)-N-(2-Hydroxyphenyl)-4-(5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanamide chemical structure, C21H20N2O4S2, CAS 303792-74-7
(Z)-N-(2-Hydroxyphenyl)-4-(5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanamide
CAS 303792-74-7C21H20N2O4S2
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(3-methylphenyl)butanamide chemical structure, C23H24N2O2S2, CAS 315242-85-4
4-[(5Z)-5-(4-Ethylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-(3-methylphenyl)butanamide
CAS 315242-85-4C23H24N2O2S2
4-{5-[(4-Chlorophenyl)methylene]-4-oxo-2-thioxo(1,3-thiazolidin-3-yl)}-N-(4-su lfamoylphenyl)butanamide chemical structure, C20H18ClN3O4S3, CAS 5218-03-1
4-{5-[(4-Chlorophenyl)methylene]-4-oxo-2-thioxo(1,3-thiazolidin-3-yl)}-N-(4-su lfamoylphenyl)butanamide
CAS 5218-03-1C20H18ClN3O4S3