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Murcko scaffold

Ring system with 4 rings and 20 atoms

17 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 20
Chemicals: 17
With full pages: 3

Scaffold SMILES

c1ccc(Cn2cnc3cnc4ccccc4c32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(Cn2cnc3cnc4ccccc4c32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

Bbiq chemical structure, C21H22N4, CAS 1229024-57-0

CAS 1229024-57-0C₂₁H₂₂N₄

1-[[3-(Aminomethyl)phenyl]methyl]-2-Butyl-Imidazo[4,5-C]quinolin-4-Amine chemical structure, C22H25N5, CAS 1258457-58-7

1-[[3-(Aminomethyl)phenyl]methyl]-2-Butyl-Imidazo[4,5-C]quinolin-4-Amine

CAS 1258457-58-7C₂₂H₂₅N₅

1-[[4-(Aminomethyl)phenyl]methyl]-2-Butyl-Imidazo[4,5-C]quinolin-4-Amine chemical structure, C22H25N5, CAS 1258457-59-8

1-[[4-(Aminomethyl)phenyl]methyl]-2-Butyl-Imidazo[4,5-C]quinolin-4-Amine

CAS 1258457-59-8C₂₂H₂₅N₅

1-[(4-Aminophenyl)methyl]-2-butylimidazo[4,5-c]quinolin-4-amine chemical structure, C21H23N5, CAS 1610431-21-4

1-[(4-Aminophenyl)methyl]-2-butylimidazo[4,5-c]quinolin-4-amine

CAS 1610431-21-4C₂₁H₂₃N₅

2-Butyl-1-[(4-nitrophenyl)methyl]imidazo[4,5-c]quinolin-4-amine chemical structure, C21H21N5O2, CAS 1610431-20-3

2-Butyl-1-[(4-nitrophenyl)methyl]imidazo[4,5-c]quinolin-4-amine

CAS 1610431-20-3C₂₁H₂₁N₅O₂

2-Butyl-1-[(4-nitrophenyl)methyl]imidazo[4,5-c]quinoline chemical structure, C21H20N4O2, CAS 1610431-19-0

2-Butyl-1-[(4-nitrophenyl)methyl]imidazo[4,5-c]quinoline

CAS 1610431-19-0C₂₁H₂₀N₄O₂

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride chemical structure, C22H27Cl2N5, CAS 1620278-72-9

1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride

CAS 1620278-72-9C₂₂H₂₇Cl₂N₅

Methyl 4-[(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl]benzoate chemical structure, C23H24N4O2, CAS 1510714-10-9

Methyl 4-[(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)methyl]benzoate

CAS 1510714-10-9C₂₃H₂₄N₄O₂

TLR7/8 agonist 6 chemical structure, C24H27N5O2, CAS 2115702-83-3

TLR7/8 agonist 6

CAS 2115702-83-3C₂₄H₂₇N₅O₂

TLR7 agonist 23 chemical structure, C21H22N4O2, CAS 2408268-38-0

TLR7 agonist 23

CAS 2408268-38-0C₂₁H₂₂N₄O₂

TLR7/8 antagonist 1 chemical structure, C24H27N5O2, CAS 2901020-63-9

TLR7/8 antagonist 1

CAS 2901020-63-9C₂₄H₂₇N₅O₂

H7B8HQ5Rgq chemical structure, C25H29N5O2, CAS 3028593-61-2

CAS 3028593-61-2C₂₅H₂₉N₅O₂

TLR7 agonist 16 chemical structure, C25H29N5O2, CAS 2832199-56-9

TLR7 agonist 16

CAS 2832199-56-9C₂₅H₂₉N₅O₂

TLR7 agonist 15 chemical structure, C26H31N5O, CAS 2832199-53-6

TLR7 agonist 15

CAS 2832199-53-6C₂₆H₃₁N₅O

C12-TLRa chemical structure, C46H73N5O2, CAS 3067466-15-0

CAS 3067466-15-0C₄₆H₇₃N₅O₂

TLR7 agonist 14 chemical structure, C29H36N6O3, CAS 2832199-45-6

TLR7 agonist 14

CAS 2832199-45-6C₂₉H₃₆N₆O₃

TLR7 agonist 20 chemical structure, C22H24N4O, CAS 3029695-00-6

TLR7 agonist 20

CAS 3029695-00-6C₂₂H₂₄N₄O