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Murcko scaffold

Ring system with 4 rings and 20 atoms

112 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
112
With full pages
6
Scaffold SMILES

c1ccc(N=c2ssc3c2-c2ccccc2NC3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N=c2ssc3c2-c2ccccc2NC3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 112 chemicals

N-[(1Z)-4,4-Dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]-2,4-dimethoxyaniline chemical structure, C20H20N2O2S2, CAS 309287-35-2
N-[(1Z)-4,4-Dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]-2,4-dimethoxyaniline
CAS 309287-35-2C20H20N2O2S2
4-{[(1Z)-4,4,7,8-Tetramethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide chemical structure, C20H21N3O2S3, CAS 309731-18-8
4-{[(1Z)-4,4,7,8-Tetramethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide
CAS 309731-18-8C20H21N3O2S3
4-{[(1E)-4,4,8-Trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide chemical structure, C19H19N3O2S3, CAS 337484-32-9
4-{[(1E)-4,4,8-Trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide
CAS 337484-32-9C19H19N3O2S3
4-{[(1Z)-4,4,7-Trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide chemical structure, C19H19N3O2S3, CAS 337484-34-1
4-{[(1Z)-4,4,7-Trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide
CAS 337484-34-1C19H19N3O2S3
4-{[(1Z)-4,4-Dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide chemical structure, C18H17N3O2S3, CAS 337484-38-5
4-{[(1Z)-4,4-Dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide
CAS 337484-38-5C18H17N3O2S3
N-[4-[(4,4,5,8-Tetramethyldithiolo[3,4-c]quinolin-1-ylidene)amino]phenyl]sulfonylacetamide chemical structure, C22H23N3O3S3, CAS 355824-76-9
N-[4-[(4,4,5,8-Tetramethyldithiolo[3,4-c]quinolin-1-ylidene)amino]phenyl]sulfonylacetamide
CAS 355824-76-9C22H23N3O3S3
4-Methoxy-N-[(1E)-7-methoxy-4,4-dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline chemical structure, C20H20N2O2S2, CAS 352642-64-9
4-Methoxy-N-[(1E)-7-methoxy-4,4-dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline
CAS 352642-64-9C20H20N2O2S2
N-[(1Z)-4,4-Dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]-2,5-dimethoxyaniline chemical structure, C20H20N2O2S2, CAS 351470-34-3
N-[(1Z)-4,4-Dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]-2,5-dimethoxyaniline
CAS 351470-34-3C20H20N2O2S2
4-{[(1Z)-8-Methoxy-4,4-dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide chemical structure, C19H19N3O3S3, CAS 337484-36-3
4-{[(1Z)-8-Methoxy-4,4-dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]amino}benzenesulfonamide
CAS 337484-36-3C19H19N3O3S3
N-(3-Chlorophenyl)-8-ethoxy-4,4-dimethyl-5H-dithiolo[3,4-c]quinolin-1-imine chemical structure, C20H19ClN2OS2, CAS 331661-23-5
N-(3-Chlorophenyl)-8-ethoxy-4,4-dimethyl-5H-dithiolo[3,4-c]quinolin-1-imine
CAS 331661-23-5C20H19ClN2OS2
5-Chloro-N-[(1Z)-8-ethoxy-4,4-dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]-2-methoxyaniline chemical structure, C21H21ClN2O2S2, CAS 370573-89-0
5-Chloro-N-[(1Z)-8-ethoxy-4,4-dimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]-2-methoxyaniline
CAS 370573-89-0C21H21ClN2O2S2
N-(3,4-Dichlorophenyl)-4,4,8-trimethyl-5H-dithiolo[3,4-c]quinolin-1-imine chemical structure, C19H16Cl2N2S2, CAS 329207-03-6
N-(3,4-Dichlorophenyl)-4,4,8-trimethyl-5H-dithiolo[3,4-c]quinolin-1-imine
CAS 329207-03-6C19H16Cl2N2S2
N-(3-Fluorophenyl)-4,4,7-trimethyl-5H-dithiolo[3,4-c]quinolin-1-imine chemical structure, C19H17FN2S2, CAS 331661-19-9
N-(3-Fluorophenyl)-4,4,7-trimethyl-5H-dithiolo[3,4-c]quinolin-1-imine
CAS 331661-19-9C19H17FN2S2
3,4-Dimethyl-N-[(1Z)-4,4,7-trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline chemical structure, C21H22N2S2, CAS 331661-26-8
3,4-Dimethyl-N-[(1Z)-4,4,7-trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline
CAS 331661-26-8C21H22N2S2
N-(3-Chlorophenyl)-4,4,7-trimethyl-5H-dithiolo[3,4-c]quinolin-1-imine chemical structure, C19H17ClN2S2, CAS 331661-22-4
N-(3-Chlorophenyl)-4,4,7-trimethyl-5H-dithiolo[3,4-c]quinolin-1-imine
CAS 331661-22-4C19H17ClN2S2
2,5-Dimethoxy-N-[(1Z)-4,4,8-trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline chemical structure, C21H22N2O2S2, CAS 351470-36-5
2,5-Dimethoxy-N-[(1Z)-4,4,8-trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline
CAS 351470-36-5C21H22N2O2S2
N-(3,4-Dichlorophenyl)-4,4,7-trimethyl-5H-dithiolo[3,4-c]quinolin-1-imine chemical structure, C19H16Cl2N2S2, CAS 327168-20-7
N-(3,4-Dichlorophenyl)-4,4,7-trimethyl-5H-dithiolo[3,4-c]quinolin-1-imine
CAS 327168-20-7C19H16Cl2N2S2
2,3-Dimethyl-N-[(1Z)-4,4,7-trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline chemical structure, C21H22N2S2, CAS 351337-77-4
2,3-Dimethyl-N-[(1Z)-4,4,7-trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline
CAS 351337-77-4C21H22N2S2
N-(4-Methoxyphenyl)-4,4,7,8-tetramethyl-5H-dithiolo[3,4-c]quinolin-1-imine chemical structure, C21H22N2OS2, CAS 352642-65-0
N-(4-Methoxyphenyl)-4,4,7,8-tetramethyl-5H-dithiolo[3,4-c]quinolin-1-imine
CAS 352642-65-0C21H22N2OS2
4-Ethoxy-N-[(1Z)-4,4,6,8-tetramethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline chemical structure, C22H24N2OS2, CAS 385386-73-2
4-Ethoxy-N-[(1Z)-4,4,6,8-tetramethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline
CAS 385386-73-2C22H24N2OS2
N-(3,4-Dichlorophenyl)-4,4-dimethyl-5H-dithiolo[3,4-c]quinolin-1-imine chemical structure, C18H14Cl2N2S2, CAS 327167-73-7
N-(3,4-Dichlorophenyl)-4,4-dimethyl-5H-dithiolo[3,4-c]quinolin-1-imine
CAS 327167-73-7C18H14Cl2N2S2
8-Ethoxy-N-(4-ethylphenyl)-4,4-dimethyl-5H-dithiolo[3,4-c]quinolin-1-imine chemical structure, C22H24N2OS2, CAS 327170-70-7
8-Ethoxy-N-(4-ethylphenyl)-4,4-dimethyl-5H-dithiolo[3,4-c]quinolin-1-imine
CAS 327170-70-7C22H24N2OS2
2,5-Dichloro-N-[(1Z)-4,4,7-trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline chemical structure, C19H16Cl2N2S2, CAS 500195-04-0
2,5-Dichloro-N-[(1Z)-4,4,7-trimethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline
CAS 500195-04-0C19H16Cl2N2S2
2-Methoxy-N-[(1Z)-4,4,6,8-tetramethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline chemical structure, C21H22N2OS2, CAS 385420-75-7
2-Methoxy-N-[(1Z)-4,4,6,8-tetramethyl-4,5-dihydro-1H-[1,2]dithiolo[3,4-c]quinolin-1-ylidene]aniline
CAS 385420-75-7C21H22N2OS2