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Murcko scaffold

1,2,3,4-Tetrahydroquinazolin-2-one scaffold

163 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 11
Chemicals: 163
With full pages: 20

Scaffold SMILES

O=C1NCc2ccccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1,2,3,4-Tetrahydroquinazolin-2-one page

Murcko scaffold O=C1NCc2ccccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 163 chemicals

3-Ethyl-4-methyl-3,4-dihydroquinazolin-2-ol chemical structure, C11H14N2O, CAS 32150-47-3

3-Ethyl-4-methyl-3,4-dihydroquinazolin-2-ol

CAS 32150-47-3C₁₁H₁₄N₂O

2(1H)-Quinazolinone, 4-(1-butynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)- chemical structure, C13H9F5N2O, CAS 214287-74-8

2(1H)-Quinazolinone, 4-(1-butynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-

CAS 214287-74-8C₁₃H₉F₅N₂O

2(1H)-Quinazolinone, 5,6-difluoro-3,4-dihydro-4-(3-methyl-1-butynyl)-4-(trifluoromethyl)- chemical structure, C14H11F5N2O, CAS 214287-72-6

2(1H)-Quinazolinone, 5,6-difluoro-3,4-dihydro-4-(3-methyl-1-butynyl)-4-(trifluoromethyl)-

CAS 214287-72-6C₁₄H₁₁F₅N₂O

4-But-1-ynyl-6-chloro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one chemical structure, C13H10ClF3N2O, CAS 214287-65-7

4-But-1-ynyl-6-chloro-4-(trifluoromethyl)-1,3-dihydroquinazolin-2-one

CAS 214287-65-7C₁₃H₁₀ClF₃N₂O

6-Chloro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one chemical structure, C14H12ClF3N2O, CAS 214287-63-5

6-Chloro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

CAS 214287-63-5C₁₄H₁₂ClF₃N₂O

2(1H)-Quinazolinone, 5,6-difluoro-3,4-dihydro-4-(3-methyl-1-butynyl)-4-(trifluoromethyl)-, (4S)- chemical structure, C14H11F5N2O, CAS 214287-92-0

2(1H)-Quinazolinone, 5,6-difluoro-3,4-dihydro-4-(3-methyl-1-butynyl)-4-(trifluoromethyl)-, (4S)-

CAS 214287-92-0C₁₄H₁₁F₅N₂O

6-Bromo-3-methyl-1,2,3,4-tetrahydroquinazolin-2-one chemical structure, C9H9BrN2O, CAS 328956-24-7

6-Bromo-3-methyl-1,2,3,4-tetrahydroquinazolin-2-one

CAS 328956-24-7C₉H₉BrN₂O

3,4-Dihydro-3-methyl-2(1H)-quinazolinone chemical structure, C9H10N2O, CAS 24365-65-9

3,4-Dihydro-3-methyl-2(1H)-quinazolinone

CAS 24365-65-9C₉H₁₀N₂O

(3-Methyl-2-oxo-3,4-dihydroquinazolin-1(2H)-yl)acetic acid chemical structure, C11H12N2O3, CAS 696637-93-1

(3-Methyl-2-oxo-3,4-dihydroquinazolin-1(2H)-yl)acetic acid

CAS 696637-93-1C₁₁H₁₂N₂O₃

Ethyl (3-methyl-2-oxo-3,4-dihydroquinazolin-1(2H)-yl)acetate chemical structure, C13H16N2O3, CAS 899367-77-2

Ethyl (3-methyl-2-oxo-3,4-dihydroquinazolin-1(2H)-yl)acetate

CAS 899367-77-2C₁₃H₁₆N₂O₃

6-Chloro-4-hydroxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one chemical structure, C9H6ClF3N2O2, CAS 214288-00-3

6-Chloro-4-hydroxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

CAS 214288-00-3C₉H₆ClF₃N₂O₂

5-Fluoro-4-hydroxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one chemical structure, C9H6F4N2O2, CAS 277301-98-1

5-Fluoro-4-hydroxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

CAS 277301-98-1C₉H₆F₄N₂O₂

4-Hydroxy-6-methoxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one chemical structure, C10H9F3N2O3, CAS 214288-02-5

4-Hydroxy-6-methoxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

CAS 214288-02-5C₁₀H₉F₃N₂O₃

8-Amino-3-methyl-3,4-dihydroquinazolin-2(1H)-one chemical structure, C9H11N3O, CAS 148890-77-1

8-Amino-3-methyl-3,4-dihydroquinazolin-2(1H)-one

CAS 148890-77-1C₉H₁₁N₃O

Methyl 2-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxylate chemical structure, C10H10N2O3, CAS 320726-98-5

Methyl 2-oxo-1,2,3,4-tetrahydroquinazoline-6-carboxylate

CAS 320726-98-5C₁₀H₁₀N₂O₃

6-Fluoro-4-hydroxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one chemical structure, C9H6F4N2O2, CAS 214288-09-2

6-Fluoro-4-hydroxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

CAS 214288-09-2C₉H₆F₄N₂O₂

3,4-Dihydro-4-(trifluoromethyl)-4-hydroxy-5,6-difluoroquinazoline-2(1H)-one chemical structure, C9H5F5N2O2, CAS 214288-04-7

3,4-Dihydro-4-(trifluoromethyl)-4-hydroxy-5,6-difluoroquinazoline-2(1H)-one

CAS 214288-04-7C₉H₅F₅N₂O₂

1,2,3,4-Tetrahydro-3-methyl-2-oxo-6-quinazolinecarboxylic acid chemical structure, C10H10N2O3, CAS 118621-07-1

1,2,3,4-Tetrahydro-3-methyl-2-oxo-6-quinazolinecarboxylic acid

CAS 118621-07-1C₁₀H₁₀N₂O₃

5-Chloro-4-hydroxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one chemical structure, C9H6ClF3N2O2, CAS 277301-99-2

5-Chloro-4-hydroxy-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

CAS 277301-99-2C₉H₆ClF₃N₂O₂

2-(2-Oxo-1,2,3,4-tetrahydroquinazolin-4-yl)acetic acid chemical structure, C10H10N2O3, CAS 59552-96-4

2-(2-Oxo-1,2,3,4-tetrahydroquinazolin-4-yl)acetic acid

CAS 59552-96-4C₁₀H₁₀N₂O₃

1,2,3,4-Tetrahydroquinazolin-2-one chemical structure, C8H8N2O, CAS 66655-67-2

1,2,3,4-Tetrahydroquinazolin-2-one

CAS 66655-67-2C₈H₈N₂O

4-Methyl-3,4-dihydro-1H-quinazolin-2-one chemical structure, C9H10N2O, CAS 31402-74-1

4-Methyl-3,4-dihydro-1H-quinazolin-2-one

CAS 31402-74-1C₉H₁₀N₂O

6-Methoxy-3,4-dihydroquinazolin-2(1H)-one chemical structure, C9H10N2O2, CAS 105763-69-7

6-Methoxy-3,4-dihydroquinazolin-2(1H)-one

CAS 105763-69-7C₉H₁₀N₂O₂

6-Chloro-3,4-dihydro-2(1H)-quinazolinone chemical structure, C8H7ClN2O, CAS 108047-40-1

6-Chloro-3,4-dihydro-2(1H)-quinazolinone

CAS 108047-40-1C₈H₇ClN₂O