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Murcko scaffold

Ring system with 4 rings and 25 atoms

38 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 38
With full pages: 12

Scaffold SMILES

O=C1NC(=S)SC1=Cc1c(N2CCOCC2)nc2ccccn2c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(=S)SC1=Cc1c(N2CCOCC2)nc2ccccn2c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

7-Methyl-3-[(Z)-(3-methyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C18H18N4O3S2, CAS 383371-79-7

7-Methyl-3-[(Z)-(3-methyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 383371-79-7C₁₈H₁₈N₄O₃S₂

(Z)-3-Methyl-5-((9-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one chemical structure, C18H18N4O3S2, CAS 324566-68-9

(Z)-3-Methyl-5-((9-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one

CAS 324566-68-9C₁₈H₁₈N₄O₃S₂

3-[(Z)-(3-Isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-7-methyl-2-(4-morpholinyl)-4H-pyrido[1,2-A]pyrimidin-4-one chemical structure, C21H24N4O3S2, CAS 381712-65-8

3-[(Z)-(3-Isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-7-methyl-2-(4-morpholinyl)-4H-pyrido[1,2-A]pyrimidin-4-one

CAS 381712-65-8C₂₁H₂₄N₄O₃S₂

3-[(Z)-(3-Isopropyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-7-methyl-2-(4-morpholinyl)-4H-pyrido[1,2-A]pyrimidin-4-one chemical structure, C20H22N4O3S2, CAS 380583-16-4

3-[(Z)-(3-Isopropyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-7-methyl-2-(4-morpholinyl)-4H-pyrido[1,2-A]pyrimidin-4-one

CAS 380583-16-4C₂₀H₂₂N₄O₃S₂

(Z)-5-((2-Morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-3-propyl-2-thioxothiazolidin-4-one chemical structure, C19H20N4O3S2, CAS 378757-01-8

(Z)-5-((2-Morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-3-propyl-2-thioxothiazolidin-4-one

CAS 378757-01-8C₁₉H₂₀N₄O₃S₂

2-(Morpholin-4-yl)-3-{(Z)-[4-oxo-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C19H18N4O3S2, CAS 385395-14-2

2-(Morpholin-4-yl)-3-{(Z)-[4-oxo-3-(prop-2-en-1-yl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 385395-14-2C₁₉H₁₈N₄O₃S₂

3-[(Z)-(3-Methyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C17H16N4O3S2, CAS 385388-33-0

3-[(Z)-(3-Methyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 385388-33-0C₁₇H₁₆N₄O₃S₂

3-(5-{[9-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)propanoic acid chemical structure, C20H20N4O5S2, CAS 438244-18-9

3-(5-{[9-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)propanoic acid

CAS 438244-18-9C₂₀H₂₀N₄O₅S₂

2-(Morpholin-4-yl)-3-{(Z)-[4-oxo-3-(propan-2-yl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C19H20N4O3S2, CAS 384369-83-9

2-(Morpholin-4-yl)-3-{(Z)-[4-oxo-3-(propan-2-yl)-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 384369-83-9C₁₉H₂₀N₄O₃S₂

(Z)-3-(2-Methoxyethyl)-5-((7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one chemical structure, C20H22N4O4S2, CAS 380582-38-7

(Z)-3-(2-Methoxyethyl)-5-((7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one

CAS 380582-38-7C₂₀H₂₂N₄O₄S₂

7-Methyl-2-(4-morpholinyl)-3-((Z)-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)-4H-pyrido(1,2-A)pyrimidin-4-one chemical structure, C20H22N4O3S2, CAS 380868-66-6

7-Methyl-2-(4-morpholinyl)-3-((Z)-(4-oxo-3-propyl-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)-4H-pyrido(1,2-A)pyrimidin-4-one

CAS 380868-66-6C₂₀H₂₂N₄O₃S₂

(Z)-3-Ethyl-5-((9-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one chemical structure, C19H20N4O3S2, CAS 324566-74-7

(Z)-3-Ethyl-5-((9-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one

CAS 324566-74-7C₁₉H₂₀N₄O₃S₂

3-{(Z)-[3-(3-Ethoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C21H24N4O4S2, CAS 488130-27-4

3-{(Z)-[3-(3-Ethoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 488130-27-4C₂₁H₂₄N₄O₄S₂

3-{(Z)-[3-(3-Methoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C20H22N4O4S2, CAS 442552-29-6

3-{(Z)-[3-(3-Methoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 442552-29-6C₂₀H₂₂N₄O₄S₂

3-{(Z)-[3-(3-Ethoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-9-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C22H26N4O4S2, CAS 488724-67-0

3-{(Z)-[3-(3-Ethoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-9-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 488724-67-0C₂₂H₂₆N₄O₄S₂

(Z)-3-(2-Methoxyethyl)-5-((9-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one chemical structure, C20H22N4O4S2, CAS 500277-12-3

(Z)-3-(2-Methoxyethyl)-5-((9-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one

CAS 500277-12-3C₂₀H₂₂N₄O₄S₂

(Z)-3-(2-Methoxyethyl)-5-((2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one chemical structure, C19H20N4O4S2, CAS 499208-70-7

(Z)-3-(2-Methoxyethyl)-5-((2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)methylene)-2-thioxothiazolidin-4-one

CAS 499208-70-7C₁₉H₂₀N₄O₄S₂

3-{(Z)-[3-(3-Ethoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-7-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C22H26N4O4S2, CAS 499211-67-5

3-{(Z)-[3-(3-Ethoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-7-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 499211-67-5C₂₂H₂₆N₄O₄S₂

3-{(Z)-[3-(3-Methoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-9-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C21H24N4O4S2, CAS 499211-79-9

3-{(Z)-[3-(3-Methoxypropyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]methyl}-9-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 499211-79-9C₂₁H₂₄N₄O₄S₂

3-((Z)-(3-Isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)-2-(4-morpholinyl)-4H-pyrido(1,2-A)pyrimidin-4-one chemical structure, C20H22N4O3S2, CAS 442552-51-4

3-((Z)-(3-Isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)-2-(4-morpholinyl)-4H-pyrido(1,2-A)pyrimidin-4-one

CAS 442552-51-4C₂₀H₂₂N₄O₃S₂

2-(2,6-Dimethylmorpholin-4-yl)-3-[(Z)-(3-ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-9-methyl-4H-pyrido[1,2-a]pyrimidin-4-one chemical structure, C21H24N4O3S2, CAS 374098-47-2

2-(2,6-Dimethylmorpholin-4-yl)-3-[(Z)-(3-ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-9-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

CAS 374098-47-2C₂₁H₂₄N₄O₃S₂

2-(2,6-Dimethyl-4-morpholinyl)-9-methyl-3-[(Z)-(3-methyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-4H-pyrido[1,2-A]pyrimidin-4-one chemical structure, C20H22N4O3S2, CAS 372970-11-1

2-(2,6-Dimethyl-4-morpholinyl)-9-methyl-3-[(Z)-(3-methyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-4H-pyrido[1,2-A]pyrimidin-4-one

CAS 372970-11-1C₂₀H₂₂N₄O₃S₂

2-(2,6-Dimethyl-4-morpholinyl)-3-((Z)-(3-isobutyl-4-oxo-2-thioxo-1,3-thi azolidin-5-ylidene)methyl)-9-methyl-4H-pyrido(1,2-A)pyrimidin-4-one chemical structure, C23H28N4O3S2, CAS 361995-00-8

2-(2,6-Dimethyl-4-morpholinyl)-3-((Z)-(3-isobutyl-4-oxo-2-thioxo-1,3-thi azolidin-5-ylidene)methyl)-9-methyl-4H-pyrido(1,2-A)pyrimidin-4-one

CAS 361995-00-8C₂₃H₂₈N₄O₃S₂

3-((Z)-(3-Butyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)-2-(2,6-dimethyl-4-morpholinyl)-9-methyl-4H-pyrido(1,2-A)pyrimidin-4-one chemical structure, C23H28N4O3S2, CAS 372974-19-1

3-((Z)-(3-Butyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)-2-(2,6-dimethyl-4-morpholinyl)-9-methyl-4H-pyrido(1,2-A)pyrimidin-4-one

CAS 372974-19-1C₂₃H₂₈N₄O₃S₂