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Murcko scaffold

2-((1-Oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide scaffold

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
36
With full pages
11
Scaffold SMILES

O=C(COc1cccc2c1CCNC2=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-((1-Oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide page
Murcko scaffold O=C(COc1cccc2c1CCNC2=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

2-[(2-Methyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(3-methylphenyl)acetamide chemical structure, C19H20N2O3, CAS 850904-67-5
2-[(2-Methyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(3-methylphenyl)acetamide
CAS 850904-67-5C19H20N2O3
2-[(2-Methyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(4-methylphenyl)acetamide chemical structure, C19H20N2O3, CAS 850904-68-6
2-[(2-Methyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(4-methylphenyl)acetamide
CAS 850904-68-6C19H20N2O3
N-(4-Fluorophenyl)-2-((2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C18H17FN2O3, CAS 850904-69-7
N-(4-Fluorophenyl)-2-((2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 850904-69-7C18H17FN2O3
N-(4-Methoxyphenyl)-2-((2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C19H20N2O4, CAS 850904-70-0
N-(4-Methoxyphenyl)-2-((2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 850904-70-0C19H20N2O4
N-(4-Ethoxyphenyl)-2-((2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C20H22N2O4, CAS 850904-71-1
N-(4-Ethoxyphenyl)-2-((2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 850904-71-1C20H22N2O4
N-(4-Bromophenyl)-2-[(2-methyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]acetamide chemical structure, C18H17BrN2O3, CAS 850904-72-2
N-(4-Bromophenyl)-2-[(2-methyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]acetamide
CAS 850904-72-2C18H17BrN2O3
2-((2-Ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide chemical structure, C19H20N2O3, CAS 850905-05-4
2-((2-Ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide
CAS 850905-05-4C19H20N2O3
2-[(2-Ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]-N-(4-methoxyphenyl)acetamide chemical structure, C20H22N2O4, CAS 850905-09-8
2-[(2-Ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]-N-(4-methoxyphenyl)acetamide
CAS 850905-09-8C20H22N2O4
N-(4-Ethoxyphenyl)-2-[(2-ethyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]acetamide chemical structure, C21H24N2O4, CAS 850905-10-1
N-(4-Ethoxyphenyl)-2-[(2-ethyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]acetamide
CAS 850905-10-1C21H24N2O4
N-(4-Bromophenyl)-2-((2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C19H19BrN2O3, CAS 850905-11-2
N-(4-Bromophenyl)-2-((2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 850905-11-2C19H19BrN2O3
N-(2,4-Dimethylphenyl)-2-((2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C21H24N2O3, CAS 850905-15-6
N-(2,4-Dimethylphenyl)-2-((2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 850905-15-6C21H24N2O3
N-(3,5-Dimethylphenyl)-2-((2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C21H24N2O3, CAS 850905-20-3
N-(3,5-Dimethylphenyl)-2-((2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 850905-20-3C21H24N2O3
N-(2,4-Dimethoxyphenyl)-2-[(2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]acetamide chemical structure, C21H24N2O5, CAS 850905-22-5
N-(2,4-Dimethoxyphenyl)-2-[(2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]acetamide
CAS 850905-22-5C21H24N2O5
Ethyl 4-(2-((2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamido)benzoate chemical structure, C22H24N2O5, CAS 850905-12-3
Ethyl 4-(2-((2-ethyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamido)benzoate
CAS 850905-12-3C22H24N2O5
N-(2,4-Dimethoxyphenyl)-2-((2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C20H22N2O5, CAS 850904-81-3
N-(2,4-Dimethoxyphenyl)-2-((2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 850904-81-3C20H22N2O5
2-[(2-Ethyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(3-methylphenyl)acetamide chemical structure, C20H22N2O3, CAS 850905-06-5
2-[(2-Ethyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(3-methylphenyl)acetamide
CAS 850905-06-5C20H22N2O3
2-((1-Oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide chemical structure, C17H16N2O3, CAS 886950-00-1
2-((1-Oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide
CAS 886950-00-1C17H16N2O3
2-((1-Oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(m-tolyl)acetamide chemical structure, C18H18N2O3, CAS 886950-10-3
2-((1-Oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(m-tolyl)acetamide
CAS 886950-10-3C18H18N2O3
N-(4-Ethylphenyl)-2-((1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C19H20N2O3, CAS 886950-15-8
N-(4-Ethylphenyl)-2-((1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 886950-15-8C19H20N2O3
N-(4-Butylphenyl)-2-[(1-oxo-3,4-dihydro-2H-isoquinolin-5-yl)oxy]acetamide chemical structure, C21H24N2O3, CAS 886950-20-5
N-(4-Butylphenyl)-2-[(1-oxo-3,4-dihydro-2H-isoquinolin-5-yl)oxy]acetamide
CAS 886950-20-5C21H24N2O3
N-(3-Methoxyphenyl)-2-((1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C18H18N2O4, CAS 886950-30-7
N-(3-Methoxyphenyl)-2-((1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 886950-30-7C18H18N2O4
N-(4-Methoxyphenyl)-2-((1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C18H18N2O4, CAS 886950-35-2
N-(4-Methoxyphenyl)-2-((1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 886950-35-2C18H18N2O4
N-(2-Ethoxyphenyl)-2-[(1-oxo-3,4-dihydro-2H-isoquinolin-5-yl)oxy]acetamide chemical structure, C19H20N2O4, CAS 886950-40-9
N-(2-Ethoxyphenyl)-2-[(1-oxo-3,4-dihydro-2H-isoquinolin-5-yl)oxy]acetamide
CAS 886950-40-9C19H20N2O4
N-(4-Ethoxyphenyl)-2-((1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide chemical structure, C19H20N2O4, CAS 886950-45-4
N-(4-Ethoxyphenyl)-2-((1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamide
CAS 886950-45-4C19H20N2O4