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Murcko scaffold

2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-phenylacetamide scaffold

156 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
156
With full pages
17
Scaffold SMILES

O=C(CSc1nc(=O)[nH]c2c1CCCC2)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-phenylacetamide page
Murcko scaffold O=C(CSc1nc(=O)[nH]c2c1CCCC2)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 156 chemicals

N-(4-Butylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C20H25N3O2S, CAS 946372-11-8
N-(4-Butylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 946372-11-8C20H25N3O2S
N-(3-Chloro-2-methylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C17H18ClN3O2S, CAS 959535-31-0
N-(3-Chloro-2-methylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 959535-31-0C17H18ClN3O2S
N-(3,4-Difluorophenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C16H15F2N3O2S, CAS 946269-57-4
N-(3,4-Difluorophenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 946269-57-4C16H15F2N3O2S
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-phenylacetamide chemical structure, C16H17N3O2S, CAS 1001519-80-7
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-phenylacetamide
CAS 1001519-80-7C16H17N3O2S
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-[4-(trifluoromethoxy)phenyl]acetamide chemical structure, C17H16F3N3O3S, CAS 933203-56-6
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-[4-(trifluoromethoxy)phenyl]acetamide
CAS 933203-56-6C17H16F3N3O3S
N-(2-Nitrophenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C16H16N4O4S, CAS 932961-25-6
N-(2-Nitrophenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 932961-25-6C16H16N4O4S
2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(o-tolyl)acetamide chemical structure, C17H19N3O2S, CAS 1001519-85-2
2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(o-tolyl)acetamide
CAS 1001519-85-2C17H19N3O2S
N-(3,5-Dimethoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C18H21N3O4S, CAS 946324-29-4
N-(3,5-Dimethoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 946324-29-4C18H21N3O4S
2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(m-tolyl)acetamide chemical structure, C17H19N3O2S, CAS 946372-19-6
2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(m-tolyl)acetamide
CAS 946372-19-6C17H19N3O2S
2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(p-tolyl)acetamide chemical structure, C17H19N3O2S, CAS 952978-66-4
2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(p-tolyl)acetamide
CAS 952978-66-4C17H19N3O2S
N-(2,3-Dimethylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C18H21N3O2S, CAS 1001519-87-4
N-(2,3-Dimethylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 1001519-87-4C18H21N3O2S
N-(3,5-Dimethylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C18H21N3O2S, CAS 932961-28-9
N-(3,5-Dimethylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 932961-28-9C18H21N3O2S
N-(2,5-Dimethylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C18H21N3O2S, CAS 946217-74-9
N-(2,5-Dimethylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 946217-74-9C18H21N3O2S
N-(4-Ethylphenyl)-2-((2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)acetamide chemical structure, C18H21N3O2S, CAS 933203-64-6
N-(4-Ethylphenyl)-2-((2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)acetamide
CAS 933203-64-6C18H21N3O2S
N-(2,4-Dimethylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C18H21N3O2S, CAS 946269-65-4
N-(2,4-Dimethylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 946269-65-4C18H21N3O2S
N-(3-Chloro-4-methylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C17H18ClN3O2S, CAS 1001519-89-6
N-(3-Chloro-4-methylphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 1001519-89-6C17H18ClN3O2S
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C17H16F3N3O2S, CAS 946372-23-2
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 946372-23-2C17H16F3N3O2S
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-[4-(trifluoromethyl)phenyl]acetamide chemical structure, C17H16F3N3O2S, CAS 932961-30-3
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-[4-(trifluoromethyl)phenyl]acetamide
CAS 932961-30-3C17H16F3N3O2S
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C17H16F3N3O2S, CAS 1001519-91-0
2-[(2-Oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 1001519-91-0C17H16F3N3O2S
N-(2-Methoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C17H19N3O3S, CAS 946324-33-0
N-(2-Methoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 946324-33-0C17H19N3O3S
N-(3-Methoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C17H19N3O3S, CAS 946217-78-3
N-(3-Methoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 946217-78-3C17H19N3O3S
N-(4-Methoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C17H19N3O3S, CAS 1001519-93-2
N-(4-Methoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 1001519-93-2C17H19N3O3S
N-(3,4-Dimethoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C18H21N3O4S, CAS 1001519-94-3
N-(3,4-Dimethoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 1001519-94-3C18H21N3O4S
N-(2,4-Dimethoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide chemical structure, C18H21N3O4S, CAS 946269-69-8
N-(2,4-Dimethoxyphenyl)-2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetamide
CAS 946269-69-8C18H21N3O4S