CompoundList
Sign in
Murcko scaffold

Ring system with 3 rings and 22 atoms

67 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
67
With full pages
9
Scaffold SMILES

O=C(COc1cccc2c(=O)[nH]ccc12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1cccc2c(=O)[nH]ccc12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 67 chemicals

N-(3-Methoxyphenyl)-2-(2-methyl-1-oxoisoquinolin-5-yl)oxyacetamide chemical structure, C19H18N2O4, CAS 906146-51-8
N-(3-Methoxyphenyl)-2-(2-methyl-1-oxoisoquinolin-5-yl)oxyacetamide
CAS 906146-51-8C19H18N2O4
2-[(2-Methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]-N-(4-nitrophenyl)acetamide chemical structure, C18H15N3O5, CAS 903357-88-0
2-[(2-Methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]-N-(4-nitrophenyl)acetamide
CAS 903357-88-0C18H15N3O5
Ethyl 2-[[2-(2-methyl-1-oxoisoquinolin-5-yl)oxyacetyl]amino]benzoate chemical structure, C21H20N2O5, CAS 906146-57-4
Ethyl 2-[[2-(2-methyl-1-oxoisoquinolin-5-yl)oxyacetyl]amino]benzoate
CAS 906146-57-4C21H20N2O5
Methyl 4-[[2-(2-methyl-1-oxoisoquinolin-5-yl)oxyacetyl]amino]benzoate chemical structure, C20H18N2O5, CAS 903357-95-9
Methyl 4-[[2-(2-methyl-1-oxoisoquinolin-5-yl)oxyacetyl]amino]benzoate
CAS 903357-95-9C20H18N2O5
N-(4-Fluorophenyl)-2-(2-methyl-1-oxoisoquinolin-5-yl)oxyacetamide chemical structure, C18H15FN2O3, CAS 906155-91-7
N-(4-Fluorophenyl)-2-(2-methyl-1-oxoisoquinolin-5-yl)oxyacetamide
CAS 906155-91-7C18H15FN2O3
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((2-methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)acetamide chemical structure, C19H14ClF3N2O3, CAS 903268-90-6
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((2-methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)acetamide
CAS 903268-90-6C19H14ClF3N2O3
2-((2-Methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)-N-(4-(trifluoromethoxy)phenyl)acetamide chemical structure, C19H15F3N2O4, CAS 903298-79-3
2-((2-Methyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)-N-(4-(trifluoromethoxy)phenyl)acetamide
CAS 903298-79-3C19H15F3N2O4
2-[(2-Ethyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]-N-(2-methylphenyl)acetamide chemical structure, C20H20N2O3, CAS 903359-79-5
2-[(2-Ethyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]-N-(2-methylphenyl)acetamide
CAS 903359-79-5C20H20N2O3
N-(2-Ethoxyphenyl)-2-((2-ethyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)acetamide chemical structure, C21H22N2O4, CAS 903269-49-8
N-(2-Ethoxyphenyl)-2-((2-ethyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)acetamide
CAS 903269-49-8C21H22N2O4
N-(2,4-Dimethoxyphenyl)-2-(2-ethyl-1-oxoisoquinolin-5-yl)oxyacetamide chemical structure, C21H22N2O5, CAS 906156-20-5
N-(2,4-Dimethoxyphenyl)-2-(2-ethyl-1-oxoisoquinolin-5-yl)oxyacetamide
CAS 906156-20-5C21H22N2O5
Ethyl 4-{2-[(2-ethyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]acetamido}benzoate chemical structure, C22H22N2O5, CAS 898457-20-0
Ethyl 4-{2-[(2-ethyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]acetamido}benzoate
CAS 898457-20-0C22H22N2O5
N-(3,4-Dichlorophenyl)-2-[(2-ethyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]acetamide chemical structure, C19H16Cl2N2O3, CAS 903300-32-3
N-(3,4-Dichlorophenyl)-2-[(2-ethyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy]acetamide
CAS 903300-32-3C19H16Cl2N2O3
N-(2,5-Dimethylphenyl)-2-((1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy)acetamide chemical structure, C22H24N2O3, CAS 903271-17-0
N-(2,5-Dimethylphenyl)-2-((1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy)acetamide
CAS 903271-17-0C22H24N2O3
N-(4-Methoxyphenyl)-2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamide chemical structure, C21H22N2O4, CAS 903361-77-3
N-(4-Methoxyphenyl)-2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamide
CAS 903361-77-3C21H22N2O4
N-(4-Ethoxyphenyl)-2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamide chemical structure, C22H24N2O4, CAS 903271-29-4
N-(4-Ethoxyphenyl)-2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamide
CAS 903271-29-4C22H24N2O4
N-(2,5-Dimethoxyphenyl)-2-(1-oxo-2-propylisoquinolin-5-yl)oxyacetamide chemical structure, C22H24N2O5, CAS 898411-63-7
N-(2,5-Dimethoxyphenyl)-2-(1-oxo-2-propylisoquinolin-5-yl)oxyacetamide
CAS 898411-63-7C22H24N2O5
Methyl 4-{2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamido}benzoate chemical structure, C22H22N2O5, CAS 898431-07-7
Methyl 4-{2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamido}benzoate
CAS 898431-07-7C22H22N2O5
N-(4-Acetylphenyl)-2-((1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy)acetamide chemical structure, C22H22N2O4, CAS 906156-78-3
N-(4-Acetylphenyl)-2-((1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy)acetamide
CAS 906156-78-3C22H22N2O4
N-(4-Acetamidophenyl)-2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamide chemical structure, C22H23N3O4, CAS 898457-25-5
N-(4-Acetamidophenyl)-2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamide
CAS 898457-25-5C22H23N3O4
4-{2-[(1-Oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamido}benzamide chemical structure, C21H21N3O4, CAS 903362-25-4
4-{2-[(1-Oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamido}benzamide
CAS 903362-25-4C21H21N3O4
N-(3-Chloro-4-methylphenyl)-2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamide chemical structure, C21H21ClN2O3, CAS 906157-08-2
N-(3-Chloro-4-methylphenyl)-2-[(1-oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy]acetamide
CAS 906157-08-2C21H21ClN2O3
2-((1-Oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy)-N-(4-(trifluoromethyl)phenyl)acetamide chemical structure, C21H19F3N2O3, CAS 903302-16-9
2-((1-Oxo-2-propyl-1,2-dihydroisoquinolin-5-yl)oxy)-N-(4-(trifluoromethyl)phenyl)acetamide
CAS 903302-16-9C21H19F3N2O3
N-(4-Ethoxyphenyl)-2-(1-oxo-2-prop-2-enylisoquinolin-5-yl)oxyacetamide chemical structure, C22H22N2O4, CAS 903302-69-2
N-(4-Ethoxyphenyl)-2-(1-oxo-2-prop-2-enylisoquinolin-5-yl)oxyacetamide
CAS 903302-69-2C22H22N2O4
2-((2-Allyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)-N-(2,5-dimethoxyphenyl)acetamide chemical structure, C22H22N2O5, CAS 903273-18-7
2-((2-Allyl-1-oxo-1,2-dihydroisoquinolin-5-yl)oxy)-N-(2,5-dimethoxyphenyl)acetamide
CAS 903273-18-7C22H22N2O5