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Murcko scaffold

2-(Benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl nicotinate scaffold

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
10
With full pages
7
Scaffold SMILES

O=C(COC(=O)c1cccnc1)Nc1ccc2c(c1)OCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(Benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl nicotinate page
Murcko scaffold O=C(COC(=O)c1cccnc1)Nc1ccc2c(c1)OCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

2-(Benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl nicotinate chemical structure, C15H12N2O5, CAS 387837-01-6
2-(Benzo[d][1,3]dioxol-5-ylamino)-2-oxoethyl nicotinate
CAS 387837-01-6C15H12N2O5
[(1,3-Dioxaindan-5-yl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C15H10Cl2N2O5, CAS 380542-32-5
[(1,3-Dioxaindan-5-yl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate
CAS 380542-32-5C15H10Cl2N2O5
[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl] 2-chloropyridine-3-carboxylate chemical structure, C15H11ClN2O5, CAS 389811-44-3
[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl] 2-chloropyridine-3-carboxylate
CAS 389811-44-3C15H11ClN2O5
[(1,3-Dioxaindan-5-yl)carbamoyl]methyl 6-chloropyridine-3-carboxylate chemical structure, C15H11ClN2O5, CAS 386279-27-2
[(1,3-Dioxaindan-5-yl)carbamoyl]methyl 6-chloropyridine-3-carboxylate
CAS 386279-27-2C15H11ClN2O5
[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate chemical structure, C16H14N2O5S, CAS 436825-56-8
[2-(1,3-Benzodioxol-5-ylamino)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate
CAS 436825-56-8C16H14N2O5S
[1-(1,3-Benzodioxol-5-ylamino)-1-oxopropan-2-yl] pyridine-3-carboxylate chemical structure, C16H14N2O5, CAS 730994-70-4
[1-(1,3-Benzodioxol-5-ylamino)-1-oxopropan-2-yl] pyridine-3-carboxylate
CAS 730994-70-4C16H14N2O5
[2-[(2,2-Difluoro-1,3-benzodioxol-5-yl)amino]-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate chemical structure, C16H12F2N2O5S, CAS 810688-83-6
[2-[(2,2-Difluoro-1,3-benzodioxol-5-yl)amino]-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate
CAS 810688-83-6C16H12F2N2O5S
1-[(1,3-Dioxaindan-5-yl)carbamoyl]ethyl 2-chloropyridine-3-carboxylate chemical structure, C16H13ClN2O5, CAS 869349-79-1
1-[(1,3-Dioxaindan-5-yl)carbamoyl]ethyl 2-chloropyridine-3-carboxylate
CAS 869349-79-1C16H13ClN2O5
1-[(1,3-Dioxaindan-5-yl)carbamoyl]ethyl 6-chloropyridine-3-carboxylate chemical structure, C16H13ClN2O5, CAS 877043-14-6
1-[(1,3-Dioxaindan-5-yl)carbamoyl]ethyl 6-chloropyridine-3-carboxylate
CAS 877043-14-6C16H13ClN2O5
1-[(2,2-Difluoro-1,3-dioxaindan-5-yl)carbamoyl]ethyl 2,6-dichloropyridine-3-carboxylate chemical structure, C16H10Cl2F2N2O5, CAS 1424594-35-3
1-[(2,2-Difluoro-1,3-dioxaindan-5-yl)carbamoyl]ethyl 2,6-dichloropyridine-3-carboxylate
CAS 1424594-35-3C16H10Cl2F2N2O5