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Murcko scaffold

7-Benzoyl-5-benzyl-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one scaffold

62 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
29
Chemicals
62
With full pages
4
Scaffold SMILES

O=C(c1ccccc1)c1cn(Cc2ccccc2)c2cc3c(cc2c1=O)OCO3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 7-Benzoyl-5-benzyl-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one page
Murcko scaffold O=C(c1ccccc1)c1cn(Cc2ccccc2)c2cc3c(cc2c1=O)OCO3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

7-(4-Ethoxybenzoyl)-5-[(2-fluorophenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C26H20FNO5, CAS 866016-65-1
7-(4-Ethoxybenzoyl)-5-[(2-fluorophenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866016-65-1C26H20FNO5
5-[(3-Fluorophenyl)methyl]-7-(4-methoxybenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H18FNO5, CAS 866016-66-2
5-[(3-Fluorophenyl)methyl]-7-(4-methoxybenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866016-66-2C25H18FNO5
7-(4-Ethoxybenzoyl)-5-[(4-fluorophenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C26H20FNO5, CAS 866016-69-5
7-(4-Ethoxybenzoyl)-5-[(4-fluorophenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866016-69-5C26H20FNO5
7-(4-Chlorobenzoyl)-5-[(4-fluorophenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C24H15ClFNO4, CAS 866016-70-8
7-(4-Chlorobenzoyl)-5-[(4-fluorophenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866016-70-8C24H15ClFNO4
7-(4-Methylbenzoyl)-5-[(3-methylphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C26H21NO4, CAS 866016-73-1
7-(4-Methylbenzoyl)-5-[(3-methylphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866016-73-1C26H21NO4
7-(4-Ethoxybenzoyl)-5-[(3-methylphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C27H23NO5, CAS 866016-76-4
7-(4-Ethoxybenzoyl)-5-[(3-methylphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866016-76-4C27H23NO5
7-(4-Ethoxybenzoyl)-5-[(2-methoxyphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C27H23NO6, CAS 866016-80-0
7-(4-Ethoxybenzoyl)-5-[(2-methoxyphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866016-80-0C27H23NO6
5-Benzyl-7-(4-methoxybenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H19NO5, CAS 866341-21-1
5-Benzyl-7-(4-methoxybenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866341-21-1C25H19NO5
5-[(4-Chlorophenyl)methyl]-7-(4-methoxybenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H18ClNO5, CAS 866341-24-4
5-[(4-Chlorophenyl)methyl]-7-(4-methoxybenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866341-24-4C25H18ClNO5
5-Benzyl-7-(4-methylbenzoyl)-[1,3]dioxolo[4,5-g]quinolin-8(5H)-one chemical structure, C25H19NO4, CAS 866348-91-6
5-Benzyl-7-(4-methylbenzoyl)-[1,3]dioxolo[4,5-g]quinolin-8(5H)-one
CAS 866348-91-6C25H19NO4
5-[(4-Chlorophenyl)methyl]-7-(4-methylbenzoyl)-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H18ClNO4, CAS 866348-93-8
5-[(4-Chlorophenyl)methyl]-7-(4-methylbenzoyl)-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866348-93-8C25H18ClNO4
5-[(3-Fluorophenyl)methyl]-7-(4-methylbenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H18FNO4, CAS 866348-94-9
5-[(3-Fluorophenyl)methyl]-7-(4-methylbenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866348-94-9C25H18FNO4
5-[(4-Fluorophenyl)methyl]-7-(4-methylbenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H18FNO4, CAS 888416-02-2
5-[(4-Fluorophenyl)methyl]-7-(4-methylbenzoyl)-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 888416-02-2C25H18FNO4
7-Benzoyl-5-[(2-methoxyphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H19NO5, CAS 866588-32-1
7-Benzoyl-5-[(2-methoxyphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866588-32-1C25H19NO5
7-(4-Chlorobenzoyl)-5-[(3-methoxyphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H18ClNO5, CAS 866588-39-8
7-(4-Chlorobenzoyl)-5-[(3-methoxyphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866588-39-8C25H18ClNO5
7-(4-Fluorobenzoyl)-5-[(4-methoxyphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H18FNO5, CAS 866588-43-4
7-(4-Fluorobenzoyl)-5-[(4-methoxyphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866588-43-4C25H18FNO5
7-(4-Chlorobenzoyl)-5-[(4-methoxyphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C25H18ClNO5, CAS 866588-44-5
7-(4-Chlorobenzoyl)-5-[(4-methoxyphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866588-44-5C25H18ClNO5
5-Benzyl-7-(4-ethylbenzoyl)-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C26H21NO4, CAS 866727-09-5
5-Benzyl-7-(4-ethylbenzoyl)-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866727-09-5C26H21NO4
7-(4-Ethylbenzoyl)-5-[(4-fluorophenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C26H20FNO4, CAS 866727-29-9
7-(4-Ethylbenzoyl)-5-[(4-fluorophenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866727-29-9C26H20FNO4
7-(4-Ethylbenzoyl)-5-[(2-methoxyphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C27H23NO5, CAS 866727-35-7
7-(4-Ethylbenzoyl)-5-[(2-methoxyphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866727-35-7C27H23NO5
7-(4-Ethylbenzoyl)-5-[(3-methoxyphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C27H23NO5, CAS 866727-43-7
7-(4-Ethylbenzoyl)-5-[(3-methoxyphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866727-43-7C27H23NO5
7-(4-Ethoxybenzoyl)-5-[(3-fluorophenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C26H20FNO5, CAS 866813-19-6
7-(4-Ethoxybenzoyl)-5-[(3-fluorophenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866813-19-6C26H20FNO5
7-(4-Ethoxybenzoyl)-5-[(3-methoxyphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C27H23NO6, CAS 866813-27-6
7-(4-Ethoxybenzoyl)-5-[(3-methoxyphenyl)methyl]-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 866813-27-6C27H23NO6
7-(3,4-Dimethylbenzoyl)-5-[(3-methylphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one chemical structure, C27H23NO4, CAS 904451-18-9
7-(3,4-Dimethylbenzoyl)-5-[(3-methylphenyl)methyl]-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
CAS 904451-18-9C27H23NO4