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Murcko scaffold

Cyclotetrasiloxane scaffold

52 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
8
Chemicals
52
With full pages
7
Scaffold SMILES

O1[SiH2]O[SiH2]O[SiH2]O[SiH2]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Cyclotetrasiloxane page
Murcko scaffold O1[SiH2]O[SiH2]O[SiH2]O[SiH2]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

Octamethylcyclotetrasiloxane chemical structure, C8H24O4Si4, CAS 556-67-2
Octamethylcyclotetrasiloxane
CAS 556-67-2C8H24O4Si4
2,2,4,4,6,6,8-Heptamethylcyclotetrasiloxane chemical structure, C7H22O4Si4, CAS 15721-05-8
2,2,4,4,6,6,8-Heptamethylcyclotetrasiloxane
CAS 15721-05-8C7H22O4Si4
(3,3,3-Trifluoropropyl)methylsiloxane cyclic tetramer chemical structure, C16H28F12O4Si4, CAS 429-67-4
(3,3,3-Trifluoropropyl)methylsiloxane cyclic tetramer
CAS 429-67-4C16H28F12O4Si4
1,3,5,7-Tetramethylcyclotetrasiloxane chemical structure, C4H16O4Si4, CAS 2370-88-9
1,3,5,7-Tetramethylcyclotetrasiloxane
CAS 2370-88-9C4H16O4Si4
1,3,5,7-Tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane chemical structure, C12H24O4Si4, CAS 2554-06-5
1,3,5,7-Tetramethyl-1,3,5,7-tetravinylcyclotetrasiloxane
CAS 2554-06-5C12H24O4Si4
2,4,6,8-Tetrabutyl-2,4,6,8-tetramethylcyclotetrasiloxane chemical structure, C20H48O4Si4, CAS 14685-29-1
2,4,6,8-Tetrabutyl-2,4,6,8-tetramethylcyclotetrasiloxane
CAS 14685-29-1C20H48O4Si4
Cyclotetrasiloxane, 2-(chloromethyl)-2,4,4,6,6,8,8-heptamethyl- chemical structure, C8H23ClO4Si4, CAS 17882-66-5
Cyclotetrasiloxane, 2-(chloromethyl)-2,4,4,6,6,8,8-heptamethyl-
CAS 17882-66-5C8H23ClO4Si4
Ethanamine, N,N',N''-((8-butyl-2,4,6,8-tetramethylcyclotetrasiloxane-2,4,6-triyl)tris(oxy))tris(N-ethyl- chemical structure, C20H51N3O7Si4, CAS 22803-29-8
Ethanamine, N,N',N''-((8-butyl-2,4,6,8-tetramethylcyclotetrasiloxane-2,4,6-triyl)tris(oxy))tris(N-ethyl-
CAS 22803-29-8C20H51N3O7Si4
Ethanamine, N,N',N''-[(2,4,6,8,8-pentamethylcyclotetrasiloxane-2,4,6-triyl)tris(oxy)]tris[N-ethyl- chemical structure, C17H45N3O7Si4, CAS 66558-73-4
Ethanamine, N,N',N''-[(2,4,6,8,8-pentamethylcyclotetrasiloxane-2,4,6-triyl)tris(oxy)]tris[N-ethyl-
CAS 66558-73-4C17H45N3O7Si4
((6,8-Dibutyl-2,4,6,8-tetramethylcyclotetrasiloxane-2,4-diyl)di(oxy))bis(diethylamine) chemical structure, C20H50N2O6Si4, CAS 60228-81-1
((6,8-Dibutyl-2,4,6,8-tetramethylcyclotetrasiloxane-2,4-diyl)di(oxy))bis(diethylamine)
CAS 60228-81-1C20H50N2O6Si4
Cyclotetrasiloxane, 2-methyl-2,4,4,6,6,8,8-heptakis(1-methylpropoxy)- chemical structure, C29H66O11Si4, CAS 70969-52-7
Cyclotetrasiloxane, 2-methyl-2,4,4,6,6,8,8-heptakis(1-methylpropoxy)-
CAS 70969-52-7C29H66O11Si4
Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octakis(1-methylpropoxy)- chemical structure, C32H72O12Si4, CAS 70969-56-1
Cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octakis(1-methylpropoxy)-
CAS 70969-56-1C32H72O12Si4
2,2,4,4,6,6,8,8-Octaethylcyclotetrasiloxane chemical structure, C16H40O4Si4, CAS 1451-99-6
2,2,4,4,6,6,8,8-Octaethylcyclotetrasiloxane
CAS 1451-99-6C16H40O4Si4
1,3,5,7-Tetrakis(3-aminopropyl)-1,3,5,7-tetramethylcyclotetrasiloxane chemical structure, C16H44N4O4Si4, CAS 85191-11-3
1,3,5,7-Tetrakis(3-aminopropyl)-1,3,5,7-tetramethylcyclotetrasiloxane
CAS 85191-11-3C16H44N4O4Si4
2-Propenoic acid, 1,1',1'',1'''-[(2,4,6,8-tetramethylcyclotetrasiloxane-2,4,6,8-tetrayl)tetra-3,1-propanediyl] ester chemical structure, C28H48O12Si4, CAS 71550-64-6
2-Propenoic acid, 1,1',1'',1'''-[(2,4,6,8-tetramethylcyclotetrasiloxane-2,4,6,8-tetrayl)tetra-3,1-propanediyl] ester
CAS 71550-64-6C28H48O12Si4
Cyclotetrasiloxane chemical structure, H8O4Si4, CAS 293-51-6
Cyclotetrasiloxane
CAS 293-51-6H8O4Si4
Heptamethylvinylcyclotetrasiloxane chemical structure, C9H24O4Si4, CAS 3763-39-1
Heptamethylvinylcyclotetrasiloxane
CAS 3763-39-1C9H24O4Si4
2,4,6,8-Tetraethyl-2,4,6,8-tetramethylcyclotetrasiloxane chemical structure, C12H32O4Si4, CAS 7623-01-0
2,4,6,8-Tetraethyl-2,4,6,8-tetramethylcyclotetrasiloxane
CAS 7623-01-0C12H32O4Si4
2-(Iodomethyl)-2,4,4,6,6,8,8-heptamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane chemical structure, C8H23IO4Si4, CAS 17882-88-1
2-(Iodomethyl)-2,4,4,6,6,8,8-heptamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane
CAS 17882-88-1C8H23IO4Si4
2-Butoxy-2,4,6,8-tetraethylcyclotetrasiloxane chemical structure, C12H32O5Si4, CAS 73420-27-6
2-Butoxy-2,4,6,8-tetraethylcyclotetrasiloxane
CAS 73420-27-6C12H32O5Si4
2,4,6,8-Tetramethyl-2,4,6,8-tetra(2-cyanoethyl)-[1,3,5,7,2,4,6,8]cyclotetrasiloxane chemical structure, C16H28N4O4Si4, CAS 1104-68-3
2,4,6,8-Tetramethyl-2,4,6,8-tetra(2-cyanoethyl)-[1,3,5,7,2,4,6,8]cyclotetrasiloxane
CAS 1104-68-3C16H28N4O4Si4
2,4,6,8-Tetramethylcyclotetrasiloxane-2,4,6,8-tetraethanethiol chemical structure, C12H32O4S4Si4, CAS 607388-75-0
2,4,6,8-Tetramethylcyclotetrasiloxane-2,4,6,8-tetraethanethiol
CAS 607388-75-0C12H32O4S4Si4
2,2,4,4,6,6,8,8-Octakis[(dimethylsilyl)oxy]-1,3,5,7,2,4,6,8-tetroxatetrasilocane chemical structure, C16H48O12Si12, CAS 161286-03-9
2,2,4,4,6,6,8,8-Octakis[(dimethylsilyl)oxy]-1,3,5,7,2,4,6,8-tetroxatetrasilocane
CAS 161286-03-9C16H48O12Si12
2-Chloro-2,4,4,6,6,8,8-heptamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane chemical structure, C7H21ClO4Si4, CAS 18297-88-6
2-Chloro-2,4,4,6,6,8,8-heptamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane
CAS 18297-88-6C7H21ClO4Si4