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Murcko scaffold

Ring system with 4 rings and 21 atoms

7 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
7
With full pages
4
Scaffold SMILES

O=c1nc2oc(-c3ccccc3)cc2cn1C1CCCO1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1nc2oc(-c3ccccc3)cc2cn1C1CCCO1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

3-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-(p-tolyl)furo[2,3-d]pyrimidin-2-one chemical structure, C18H18N2O5, CAS 319425-62-2
3-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-(p-tolyl)furo[2,3-d]pyrimidin-2-one
CAS 319425-62-2C18H18N2O5
3-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-(4-propylphenyl)furo[2,3-d]pyrimidin-2-one chemical structure, C20H22N2O5, CAS 319425-64-4
3-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-(4-propylphenyl)furo[2,3-d]pyrimidin-2-one
CAS 319425-64-4C20H22N2O5
Cf 1743 chemical structure, C22H26N2O5, CAS 319425-66-6
Cf 1743
CAS 319425-66-6C22H26N2O5
6-(4-Heptylphenyl)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]furo[2,3-d]pyrimidin-2-one chemical structure, C24H30N2O5, CAS 319425-68-8
6-(4-Heptylphenyl)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]furo[2,3-d]pyrimidin-2-one
CAS 319425-68-8C24H30N2O5
Valnivudine chemical structure, C27H35N3O6, CAS 956483-02-6
Valnivudine
CAS 956483-02-6C27H35N3O6
Fv-100 chemical structure, C27H36ClN3O6, CAS 956483-03-7
Fv-100
CAS 956483-03-7C27H36ClN3O6
Furo[2,3-d]pyrimidin-2(3H)-one, 3-[3-O-(2-chloroacetyl)-2-deoxy-beta-D-erythro-pentofuranosyl]-6-(4-pentylphenyl)- chemical structure, C24H27ClN2O6, CAS 1370288-87-1
Furo[2,3-d]pyrimidin-2(3H)-one, 3-[3-O-(2-chloroacetyl)-2-deoxy-beta-D-erythro-pentofuranosyl]-6-(4-pentylphenyl)-
CAS 1370288-87-1C24H27ClN2O6