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Murcko scaffold

Ring system with 4 rings and 24 atoms

55 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
55
With full pages
1
Scaffold SMILES

O=C1CCC(N2C(=O)c3ccc(N4CCCC4)cc3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCC(N2C(=O)c3ccc(N4CCCC4)cc3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-((R)-3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione chemical structure, C18H18FN3O5, CAS 2222118-70-7
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-((R)-3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione
CAS 2222118-70-7C18H18FN3O5
1-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]pyrrolidine-3-carbaldehyde chemical structure, C18H17N3O5, CAS 2412058-48-9
1-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]pyrrolidine-3-carbaldehyde
CAS 2412058-48-9C18H17N3O5
2-(2,6-Dioxopiperidin-3-yl)-5-(3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione chemical structure, C18H19N3O5, CAS 2412058-47-8
2-(2,6-Dioxopiperidin-3-yl)-5-(3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione
CAS 2412058-47-8C18H19N3O5
(3S)-1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pyrrolidine-3-carbaldehyde chemical structure, C18H17N3O5, CAS 2416132-75-5
(3S)-1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pyrrolidine-3-carbaldehyde
CAS 2416132-75-5C18H17N3O5
2-(2,6-Dioxopiperidin-3-yl)-5-((R)-3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione chemical structure, C18H19N3O5, CAS 2416132-50-6
2-(2,6-Dioxopiperidin-3-yl)-5-((R)-3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione
CAS 2416132-50-6C18H19N3O5
2-(2,6-Dioxopiperidin-3-yl)-5-((S)-3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione chemical structure, C18H19N3O5, CAS 2416132-51-7
2-(2,6-Dioxopiperidin-3-yl)-5-((S)-3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione
CAS 2416132-51-7C18H19N3O5
(3R)-1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pyrrolidine-3-carbaldehyde chemical structure, C18H17N3O5, CAS 2416132-74-4
(3R)-1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pyrrolidine-3-carbaldehyde
CAS 2416132-74-4C18H17N3O5
5-[3-(2-Aminoethyl)pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H22N4O4, CAS 2703770-77-6
5-[3-(2-Aminoethyl)pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703770-77-6C19H22N4O4
5-(4-Amino-2-methylpyrrolidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O4, CAS 2703765-63-1
5-(4-Amino-2-methylpyrrolidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703765-63-1C18H20N4O4
5-[(2S,4R)-2-(Aminomethyl)-4-methoxypyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H22N4O5, CAS 2728780-10-5
5-[(2S,4R)-2-(Aminomethyl)-4-methoxypyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2728780-10-5C19H22N4O5
5-[(3R)-3-Aminopyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C17H18N4O4, CAS 2728780-11-6
5-[(3R)-3-Aminopyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2728780-11-6C17H18N4O4
2-(2,6-Dioxopiperidin-3-yl)-5-[3-(methylamino)pyrrolidin-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O4, CAS 2703771-37-1
2-(2,6-Dioxopiperidin-3-yl)-5-[3-(methylamino)pyrrolidin-1-yl]-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703771-37-1C18H20N4O4
2-(2,6-Dioxopiperidin-3-yl)-5-{3-[(methylamino)methyl]pyrrolidin-1-yl}-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H22N4O4, CAS 2703765-94-8
2-(2,6-Dioxopiperidin-3-yl)-5-{3-[(methylamino)methyl]pyrrolidin-1-yl}-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703765-94-8C19H22N4O4
rac-Methyl (3R,4S)-4-(aminomethyl)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]pyrrolidine-3-carboxylate chemical structure, C20H22N4O6, CAS 2731012-00-1
rac-Methyl (3R,4S)-4-(aminomethyl)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]pyrrolidine-3-carboxylate
CAS 2731012-00-1C20H22N4O6
rac-5-[(3R,4S)-3-Amino-4-(difluoromethyl)pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H18F2N4O4, CAS 2731012-59-0
rac-5-[(3R,4S)-3-Amino-4-(difluoromethyl)pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2731012-59-0C18H18F2N4O4
5-[3-(Aminomethyl)-3-tert-butylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C22H28N4O4, CAS 2703760-81-8
5-[3-(Aminomethyl)-3-tert-butylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703760-81-8C22H28N4O4
5-[3-(Aminomethyl)-4,4-difluoro-3-methylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H20F2N4O4, CAS 2703767-52-4
5-[3-(Aminomethyl)-4,4-difluoro-3-methylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703767-52-4C19H20F2N4O4
rac-Methyl (3R,4S)-4-(aminomethyl)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]-3-fluoropyrrolidine-3-carboxylate chemical structure, C20H21FN4O6, CAS 2731011-98-4
rac-Methyl (3R,4S)-4-(aminomethyl)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]-3-fluoropyrrolidine-3-carboxylate
CAS 2731011-98-4C20H21FN4O6
5-(4-Amino-3,3-dimethylpyrrolidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H22N4O4, CAS 2703762-02-9
5-(4-Amino-3,3-dimethylpyrrolidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703762-02-9C19H22N4O4
5-[4-(Aminomethyl)-3,3-dimethylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C20H24N4O4, CAS 2703761-22-0
5-[4-(Aminomethyl)-3,3-dimethylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703761-22-0C20H24N4O4
rac-5-[(2R,3R)-3-Amino-2-methylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O4, CAS 2731012-23-8
rac-5-[(2R,3R)-3-Amino-2-methylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2731012-23-8C18H20N4O4
rac-5-[(3R,4R)-3-Amino-4-methoxypyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O5, CAS 2731012-29-4
rac-5-[(3R,4R)-3-Amino-4-methoxypyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2731012-29-4C18H20N4O5
5-[(2R,4R)-2-(Aminomethyl)-4-hydroxypyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C18H20N4O5, CAS 2728765-70-4
5-[(2R,4R)-2-(Aminomethyl)-4-hydroxypyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2728765-70-4C18H20N4O5
rac-5-[(3R,4S)-3-(Aminomethyl)-3,4-dimethylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C20H24N4O4, CAS 2731013-12-8
rac-5-[(3R,4S)-3-(Aminomethyl)-3,4-dimethylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2731013-12-8C20H24N4O4