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Murcko scaffold

2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide scaffold

12 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 21
Chemicals: 12
With full pages: 3

Scaffold SMILES

O=C(CSc1nc(=O)[nH]c2c1CCCC2)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide page

Murcko scaffold O=C(CSc1nc(=O)[nH]c2c1CCCC2)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

Ethyl 4-methyl-2-[[2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetyl]amino]-1,3-thiazole-5-carboxylate chemical structure, C17H20N4O4S2, CAS 946269-61-0

Ethyl 4-methyl-2-[[2-[(2-oxo-5,6,7,8-tetrahydro-1H-quinazolin-4-yl)sulfanyl]acetyl]amino]-1,3-thiazole-5-carboxylate

CAS 946269-61-0C₁₇H₂₀N₄O₄S₂

Ethyl 2-(2-(2-((2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)acetamido)thiazol-4-yl)acetate chemical structure, C17H20N4O4S2, CAS 898450-41-4

Ethyl 2-(2-(2-((2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)acetamido)thiazol-4-yl)acetate

CAS 898450-41-4C₁₇H₂₀N₄O₄S₂

2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C13H14N4O2S2, CAS 946217-90-9

2-((2-Oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 946217-90-9C₁₃H₁₄N₄O₂S₂

2-((1-(2-(Diethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C19H27N5O2S2, CAS 899949-81-6

2-((1-(2-(Diethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 899949-81-6C₁₉H₂₇N₅O₂S₂

2-((1-(2-(Dimethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C17H23N5O2S2, CAS 899749-25-8

2-((1-(2-(Dimethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 899749-25-8C₁₇H₂₃N₅O₂S₂

2-((1-(2-(Dimethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C18H25N5O2S2, CAS 899950-47-1

2-((1-(2-(Dimethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 899950-47-1C₁₈H₂₅N₅O₂S₂

2-((1-(2-(Diethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C20H29N5O2S2, CAS 899949-83-8

2-((1-(2-(Diethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 899949-83-8C₂₀H₂₉N₅O₂S₂

Ethyl 2-(2-((1-(2-(dimethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)acetamido)-4-methylthiazole-5-carboxylate chemical structure, C21H29N5O4S2, CAS 941920-72-5

Ethyl 2-(2-((1-(2-(dimethylamino)ethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)acetamido)-4-methylthiazole-5-carboxylate

CAS 941920-72-5C₂₁H₂₉N₅O₄S₂

2-((1-(2-Hydroxyethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C15H18N4O3S2, CAS 899743-04-5

2-((1-(2-Hydroxyethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 899743-04-5C₁₅H₁₈N₄O₃S₂

2-((1-(2-Hydroxyethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C16H20N4O3S2, CAS 920165-46-4

2-((1-(2-Hydroxyethyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 920165-46-4C₁₆H₂₀N₄O₃S₂

2-((1-(3-Hydroxypropyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C16H20N4O3S2, CAS 899743-36-3

2-((1-(3-Hydroxypropyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 899743-36-3C₁₆H₂₀N₄O₃S₂

2-((1-(3-Hydroxypropyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C17H22N4O3S2, CAS 899977-64-1

2-((1-(3-Hydroxypropyl)-2-oxo-1,2,5,6,7,8-hexahydroquinazolin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 899977-64-1C₁₇H₂₂N₄O₃S₂