Murcko scaffold
Ring system with 4 rings and 28 atoms
54 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 28
- Chemicals
- 54
- With full pages
- 4
Scaffold SMILES
O=C(c1ccccc1)N1CCN(c2cccc(NCc3ccccc3)c2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 54 chemicals
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-chlorophenyl)methanone chemical structure, C24H23ClN4O3, CAS 347353-66-6](/s/BQRIEXJIKQIADY-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-chlorophenyl)methanone
CAS 347353-66-6C24H23ClN4O3
![(4-Chlorophenyl)-[4-[4-nitro-3-[(4-propan-2-ylphenyl)methylamino]phenyl]piperazin-1-yl]methanone chemical structure, C27H29ClN4O3, CAS 347353-67-7](/s/RWKJJXXLECWZFV-UHFFFAOYSA-N.svg)
(4-Chlorophenyl)-[4-[4-nitro-3-[(4-propan-2-ylphenyl)methylamino]phenyl]piperazin-1-yl]methanone
CAS 347353-67-7C27H29ClN4O3
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(2-fluorophenyl)methanone chemical structure, C24H23FN4O3, CAS 347354-68-1](/s/ZKVCTDBVKZHMRG-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(2-fluorophenyl)methanone
CAS 347354-68-1C24H23FN4O3
![(2-Fluorophenyl)-[4-[4-nitro-3-[(4-propan-2-ylphenyl)methylamino]phenyl]piperazin-1-yl]methanone chemical structure, C27H29FN4O3, CAS 347354-02-3](/s/LPHYHYRGEFEOPT-UHFFFAOYSA-N.svg)
(2-Fluorophenyl)-[4-[4-nitro-3-[(4-propan-2-ylphenyl)methylamino]phenyl]piperazin-1-yl]methanone
CAS 347354-02-3C27H29FN4O3
![{4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl}(2-chloro-4,5-difluorophenyl)methanone chemical structure, C24H21ClF2N4O3, CAS 347355-58-2](/s/YMQWLNWDWMKZQQ-UHFFFAOYSA-N.svg)
{4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl}(2-chloro-4,5-difluorophenyl)methanone
CAS 347355-58-2C24H21ClF2N4O3
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(2-bromophenyl)methanone chemical structure, C24H23BrN4O3, CAS 347355-24-2](/s/NZARZWUSBFCXLZ-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(2-bromophenyl)methanone
CAS 347355-24-2C24H23BrN4O3
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-methylphenyl)methanone chemical structure, C25H26N4O3, CAS 347355-26-4](/s/UROCCTSNGRRGOC-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-methylphenyl)methanone
CAS 347355-26-4C25H26N4O3
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(2-chlorophenyl)methanone chemical structure, C24H23ClN4O3, CAS 347355-40-2](/s/NRAGXPLMNXDOHT-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(2-chlorophenyl)methanone
CAS 347355-40-2C24H23ClN4O3
![[4-[3-[(4-Chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]-(4-methylphenyl)methanone chemical structure, C25H25ClN4O3, CAS 347355-01-5](/s/INGNQIRKKDRQHX-UHFFFAOYSA-N.svg)
[4-[3-[(4-Chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]-(4-methylphenyl)methanone
CAS 347355-01-5C25H25ClN4O3
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-bromophenyl)methanone chemical structure, C24H23BrN4O3, CAS 330834-72-5](/s/CHDROQMNJOYXAH-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-bromophenyl)methanone
CAS 330834-72-5C24H23BrN4O3
![(2-Chlorophenyl)-[4-[3-[(4-chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]methanone chemical structure, C24H22Cl2N4O3, CAS 347356-31-4](/s/LDFGHGDJMWZINC-UHFFFAOYSA-N.svg)
(2-Chlorophenyl)-[4-[3-[(4-chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]methanone
CAS 347356-31-4C24H22Cl2N4O3
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-methoxyphenyl)methanone chemical structure, C25H26N4O4, CAS 347310-31-0](/s/JJJCGCJACVRJEH-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-methoxyphenyl)methanone
CAS 347310-31-0C25H26N4O4
![(3-Methylphenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone chemical structure, C26H28N4O3, CAS 347313-51-3](/s/DEIAJSKCTBYRHS-UHFFFAOYSA-N.svg)
(3-Methylphenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone
CAS 347313-51-3C26H28N4O3
![(4-Methoxyphenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone chemical structure, C26H28N4O4, CAS 347311-23-3](/s/MRSPMZVWICCNMA-UHFFFAOYSA-N.svg)
(4-Methoxyphenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone
CAS 347311-23-3C26H28N4O4
![(3-Chlorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone chemical structure, C25H25ClN4O3, CAS 347313-25-1](/s/JLXQMCMACJFAOW-UHFFFAOYSA-N.svg)
(3-Chlorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone
CAS 347313-25-1C25H25ClN4O3
![[4-[3-[(4-Chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]-(2-fluorophenyl)methanone chemical structure, C24H22ClFN4O3, CAS 347356-42-7](/s/GGZKBKJIDZPPSS-UHFFFAOYSA-N.svg)
[4-[3-[(4-Chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]-(2-fluorophenyl)methanone
CAS 347356-42-7C24H22ClFN4O3
![[4-[3-[(4-Chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]-(4-methoxyphenyl)methanone chemical structure, C25H25ClN4O4, CAS 347310-36-5](/s/OKASIVNUBDYNFT-UHFFFAOYSA-N.svg)
[4-[3-[(4-Chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]-(4-methoxyphenyl)methanone
CAS 347310-36-5C25H25ClN4O4
![(4-{3-[(4-Chlorobenzyl)amino]-4-nitrophenyl}piperazin-1-yl)(2-methoxyphenyl)methanone chemical structure, C25H25ClN4O4, CAS 347309-33-5](/s/FAGRLHKLIYNVOC-UHFFFAOYSA-N.svg)
(4-{3-[(4-Chlorobenzyl)amino]-4-nitrophenyl}piperazin-1-yl)(2-methoxyphenyl)methanone
CAS 347309-33-5C25H25ClN4O4
![[4-[3-[(4-Chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]-(3-methylphenyl)methanone chemical structure, C25H25ClN4O3, CAS 347313-41-1](/s/DBXYIMQUMLBIJQ-UHFFFAOYSA-N.svg)
[4-[3-[(4-Chlorophenyl)methylamino]-4-nitrophenyl]piperazin-1-yl]-(3-methylphenyl)methanone
CAS 347313-41-1C25H25ClN4O3
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3-chlorophenyl)methanone chemical structure, C24H23ClN4O3, CAS 347311-48-2](/s/KBACCDFWZXTJOI-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3-chlorophenyl)methanone
CAS 347311-48-2C24H23ClN4O3
![[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3-methylphenyl)methanone chemical structure, C25H26N4O3, CAS 347313-36-4](/s/ARIYZHPTSIVDAS-UHFFFAOYSA-N.svg)
[4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3-methylphenyl)methanone
CAS 347313-36-4C25H26N4O3
![{4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl}(2-methoxyphenyl)methanone chemical structure, C25H26N4O4, CAS 347309-16-4](/s/SVGPTIDKLHAFHX-UHFFFAOYSA-N.svg)
{4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl}(2-methoxyphenyl)methanone
CAS 347309-16-4C25H26N4O4
![(2-Fluorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone chemical structure, C25H25FN4O3, CAS 347313-92-2](/s/VEGDOOJKBWKRER-UHFFFAOYSA-N.svg)
(2-Fluorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone
CAS 347313-92-2C25H25FN4O3
![(2-Chlorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone chemical structure, C25H25ClN4O3, CAS 430451-09-5](/s/JSNPFLYQYBNJTP-UHFFFAOYSA-N.svg)
(2-Chlorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone
CAS 430451-09-5C25H25ClN4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-fluorophenyl)methanone430451-54-0C24H23FN4O3
- (4-Fluorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone430454-54-9C25H25FN4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-phenylmethanone430458-13-2C24H24N4O3
- (4-Methylphenyl)(4-{4-nitro-3-[(1-phenylethyl)amino]phenyl}piperazin-1-yl)methanone430447-61-3C26H28N4O3
- [4-[4-Nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]-phenylmethanone439946-44-8C25H26N4O3
- (4-Chlorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone430451-86-8C25H25ClN4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-ethoxyphenyl)methanone431994-06-8C26H28N4O4
- (4-tert-Butylphenyl)(4-{4-nitro-3-[(1-phenylethyl)amino]phenyl}piperazin-1-yl)methanone432503-91-8C29H34N4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3-bromophenyl)methanone432511-05-2C24H23BrN4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3-methoxyphenyl)methanone432512-19-1C25H26N4O4
- {4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl}(3-fluorophenyl)methanone432531-63-0C24H23FN4O3
- (3-Fluorophenyl)(4-{4-nitro-3-[(1-phenylethyl)amino]phenyl}piperazin-1-yl)methanone432537-52-5C25H25FN4O3
- (2-Methylphenyl)(4-{4-nitro-3-[(1-phenylethyl)amino]phenyl}piperazin-1-yl)methanone432539-17-8C26H28N4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(2-methylphenyl)methanone433234-73-2C25H26N4O3
- (4-Ethoxyphenyl)(4-{4-nitro-3-[(1-phenylethyl)amino]phenyl}piperazin-1-yl)methanone433243-53-9C27H30N4O4
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-propan-2-ylphenyl)methanone433701-87-2C27H30N4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-butoxyphenyl)methanone434295-74-6C28H32N4O4
- [4-[4-Nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]-(4-propan-2-ylphenyl)methanone509113-44-4C28H32N4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3,4-dichlorophenyl)methanone524033-85-0C24H22Cl2N4O3
- (3,4-Dichlorophenyl)-[4-[4-nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]methanone524034-83-1C25H24Cl2N4O3
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3-ethoxyphenyl)methanone591736-20-8C26H28N4O4
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(4-ethylphenyl)methanone591736-89-9C26H28N4O3
- [4-[4-Nitro-3-(1-phenylethylamino)phenyl]piperazin-1-yl]-(4-propan-2-yloxyphenyl)methanone593237-96-8C28H32N4O4
- [4-[3-(Benzylamino)-4-nitrophenyl]piperazin-1-yl]-(3-propan-2-yloxyphenyl)methanone591765-30-9C27H30N4O4
Related scaffolds
Same ring framework with different atoms or bond orders
