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Murcko scaffold

2-Phenyl-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide scaffold

27 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
27
With full pages
1
Scaffold SMILES

O=C(Nc1nncs1)c1cc(-c2ccccc2)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Phenyl-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide page
Murcko scaffold O=C(Nc1nncs1)c1cc(-c2ccccc2)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

N-(5-Methyl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide chemical structure, C19H14N4OS, CAS 349440-88-6
N-(5-Methyl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide
CAS 349440-88-6C19H14N4OS
2-(2-Methylphenyl)-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C19H14N4OS, CAS 313392-79-9
2-(2-Methylphenyl)-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 313392-79-9C19H14N4OS
2-Phenyl-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C18H12N4OS, CAS 349440-89-7
2-Phenyl-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 349440-89-7C18H12N4OS
N-[5-(2,2-Dimethylpropyl)-1,3,4-thiadiazol-2-yl]-2-(4-methoxyphenyl)quinoline-4-carboxamide chemical structure, C24H24N4O2S, CAS 438197-52-5
N-[5-(2,2-Dimethylpropyl)-1,3,4-thiadiazol-2-yl]-2-(4-methoxyphenyl)quinoline-4-carboxamide
CAS 438197-52-5C24H24N4O2S
N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide chemical structure, C20H16N4OS2, CAS 544462-92-2
N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide
CAS 544462-92-2C20H16N4OS2
N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-2-(4-methylphenyl)quinoline-4-carboxamide chemical structure, C21H18N4OS2, CAS 354549-93-2
N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-2-(4-methylphenyl)quinoline-4-carboxamide
CAS 354549-93-2C21H18N4OS2
2-Phenyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]quinoline-4-carboxamide chemical structure, C19H11F3N4OS, CAS 510736-12-6
2-Phenyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]quinoline-4-carboxamide
CAS 510736-12-6C19H11F3N4OS
2-(4-Chlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C20H15ClN4OS, CAS 362473-75-4
2-(4-Chlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 362473-75-4C20H15ClN4OS
2-(2-Chlorophenyl)-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C18H11ClN4OS, CAS 353477-31-3
2-(2-Chlorophenyl)-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 353477-31-3C18H11ClN4OS
2-(2-Chlorophenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C19H13ClN4OS, CAS 354548-60-0
2-(2-Chlorophenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 354548-60-0C19H13ClN4OS
2-(3,4-Dichlorophenyl)-N-(1,3,4-thiadiazol-2-yl)-4-quinolinecarboxamide chemical structure, C18H10Cl2N4OS, CAS 353766-84-4
2-(3,4-Dichlorophenyl)-N-(1,3,4-thiadiazol-2-yl)-4-quinolinecarboxamide
CAS 353766-84-4C18H10Cl2N4OS
2-(2-Methylphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C20H16N4OS, CAS 444926-84-5
2-(2-Methylphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 444926-84-5C20H16N4OS
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-(3-methoxyphenyl)quinoline-4-carboxamide chemical structure, C21H18N4O2S, CAS 309950-02-5
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-2-(3-methoxyphenyl)quinoline-4-carboxamide
CAS 309950-02-5C21H18N4O2S
2-Phenyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C21H18N4OS, CAS 326877-16-1
2-Phenyl-N-(5-propan-2-yl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 326877-16-1C21H18N4OS
2-(3-Ethoxyphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C21H18N4O2S, CAS 351001-09-7
2-(3-Ethoxyphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 351001-09-7C21H18N4O2S
2-(3-Bromophenyl)-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C18H11BrN4OS, CAS 303136-76-7
2-(3-Bromophenyl)-N-(1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 303136-76-7C18H11BrN4OS
2-(4-Chlorophenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C19H13ClN4OS, CAS 6129-58-4
2-(4-Chlorophenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 6129-58-4C19H13ClN4OS
N-(5-Pentan-3-yl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide chemical structure, C23H22N4OS, CAS 600147-15-7
N-(5-Pentan-3-yl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide
CAS 600147-15-7C23H22N4OS
N-[5-(Ethoxymethyl)-1,3,4-thiadiazol-2-yl]-2-phenylquinoline-4-carboxamide chemical structure, C21H18N4O2S, CAS 701247-46-3
N-[5-(Ethoxymethyl)-1,3,4-thiadiazol-2-yl]-2-phenylquinoline-4-carboxamide
CAS 701247-46-3C21H18N4O2S
2-(3,4-Dichlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide chemical structure, C20H14Cl2N4OS, CAS 292052-70-1
2-(3,4-Dichlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)quinoline-4-carboxamide
CAS 292052-70-1C20H14Cl2N4OS
N-(5-Pentyl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide chemical structure, C23H22N4OS, CAS 701947-21-9
N-(5-Pentyl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide
CAS 701947-21-9C23H22N4OS
N-[5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl]-2-phenylquinoline-4-carboxamide chemical structure, C20H16N4O2S, CAS 524677-26-7
N-[5-(Methoxymethyl)-1,3,4-thiadiazol-2-yl]-2-phenylquinoline-4-carboxamide
CAS 524677-26-7C20H16N4O2S
N-(5-Pentan-2-yl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide chemical structure, C23H22N4OS, CAS 710977-30-3
N-(5-Pentan-2-yl-1,3,4-thiadiazol-2-yl)-2-phenylquinoline-4-carboxamide
CAS 710977-30-3C23H22N4OS
2-(3-Ethoxyphenyl)-N-[5-(2-methylbutan-2-yl)-1,3,4-thiadiazol-2-yl]quinoline-4-carboxamide chemical structure, C25H26N4O2S, CAS 492429-54-6
2-(3-Ethoxyphenyl)-N-[5-(2-methylbutan-2-yl)-1,3,4-thiadiazol-2-yl]quinoline-4-carboxamide
CAS 492429-54-6C25H26N4O2S