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Murcko scaffold

Ring system with 4 rings and 24 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
9
With full pages
3
Scaffold SMILES

O=C(Nc1ccsc1)c1cc(-c2ccccc2)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccsc1)c1cc(-c2ccccc2)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

Methyl 3-[[2-(3-bromophenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate chemical structure, C22H15BrN2O3S, CAS 545348-89-8
Methyl 3-[[2-(3-bromophenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate
CAS 545348-89-8C22H15BrN2O3S
Methyl 3-[[2-(2,5-dimethylphenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate chemical structure, C24H20N2O3S, CAS 444933-68-0
Methyl 3-[[2-(2,5-dimethylphenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate
CAS 444933-68-0C24H20N2O3S
Methyl 3-[[2-(2,4-dimethoxyphenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate chemical structure, C24H20N2O5S, CAS 329049-85-6
Methyl 3-[[2-(2,4-dimethoxyphenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate
CAS 329049-85-6C24H20N2O5S
Methyl 3-[[2-(4-bromophenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate chemical structure, C22H15BrN2O3S, CAS 313392-54-0
Methyl 3-[[2-(4-bromophenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate
CAS 313392-54-0C22H15BrN2O3S
Methyl 3-[[2-(4-ethylphenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate chemical structure, C24H20N2O3S, CAS 353472-03-4
Methyl 3-[[2-(4-ethylphenyl)quinoline-4-carbonyl]amino]thiophene-2-carboxylate
CAS 353472-03-4C24H20N2O3S
3-[[[2-(3-Methylphenyl)-4-quinolinyl]-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester chemical structure, C23H18N2O3S, CAS 420092-20-2
3-[[[2-(3-Methylphenyl)-4-quinolinyl]-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester
CAS 420092-20-2C23H18N2O3S
Methyl 3-[[2-(3-chlorophenyl)-3-methylquinoline-4-carbonyl]amino]thiophene-2-carboxylate chemical structure, C23H17ClN2O3S, CAS 445025-27-4
Methyl 3-[[2-(3-chlorophenyl)-3-methylquinoline-4-carbonyl]amino]thiophene-2-carboxylate
CAS 445025-27-4C23H17ClN2O3S
Methyl 3-(6-chloro-3-methyl-2-phenylquinoline-4-carboxamido)thiophene-2-carboxylate chemical structure, C23H17ClN2O3S, CAS 777871-06-4
Methyl 3-(6-chloro-3-methyl-2-phenylquinoline-4-carboxamido)thiophene-2-carboxylate
CAS 777871-06-4C23H17ClN2O3S
Methyl 3-({[2-(4-chlorophenyl)-8-methyl-4-quinolyl]carbonyl}amino)-2-thiophenecarboxylate chemical structure, C23H17ClN2O3S, CAS 669756-81-4
Methyl 3-({[2-(4-chlorophenyl)-8-methyl-4-quinolyl]carbonyl}amino)-2-thiophenecarboxylate
CAS 669756-81-4C23H17ClN2O3S