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Murcko scaffold

2-Phenyl-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide scaffold

35 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
35
With full pages
2
Scaffold SMILES

O=C(Nc1nccs1)c1cc(-c2ccccc2)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Phenyl-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide page
Murcko scaffold O=C(Nc1nccs1)c1cc(-c2ccccc2)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

2-(3-Methylphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C20H15N3OS, CAS 303139-32-4
2-(3-Methylphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 303139-32-4C20H15N3OS
Ethyl 2-[[2-(2-chlorophenyl)quinoline-4-carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C23H18ClN3O3S, CAS 544689-81-8
Ethyl 2-[[2-(2-chlorophenyl)quinoline-4-carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate
CAS 544689-81-8C23H18ClN3O3S
2-[[2-(4-Bromophenyl)quinoline-4-carbonyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide chemical structure, C23H19BrN4O2S, CAS 438466-85-4
2-[[2-(4-Bromophenyl)quinoline-4-carbonyl]amino]-N,N,4-trimethyl-1,3-thiazole-5-carboxamide
CAS 438466-85-4C23H19BrN4O2S
Ethyl 2-[[2-(3-ethoxyphenyl)quinoline-4-carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O4S, CAS 312951-91-0
Ethyl 2-[[2-(3-ethoxyphenyl)quinoline-4-carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate
CAS 312951-91-0C25H23N3O4S
2-(4-tert-Butylphenyl)-N-{5-[(dimethylamino)carbonyl]-4-methyl-1,3-thiazol-2-yl}-4-quinolinecarboxamide chemical structure, C27H28N4O2S, CAS 438532-67-3
2-(4-tert-Butylphenyl)-N-{5-[(dimethylamino)carbonyl]-4-methyl-1,3-thiazol-2-yl}-4-quinolinecarboxamide
CAS 438532-67-3C27H28N4O2S
6-Bromo-2-(3-methoxyphenyl)-8-methyl-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C21H16BrN3O2S, CAS 723251-26-1
6-Bromo-2-(3-methoxyphenyl)-8-methyl-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 723251-26-1C21H16BrN3O2S
2-(4-Chlorophenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C19H12ClN3OS, CAS 353786-93-3
2-(4-Chlorophenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 353786-93-3C19H12ClN3OS
2-(4-Bromophenyl)-N-(4-methyl-1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C20H14BrN3OS, CAS 352678-49-0
2-(4-Bromophenyl)-N-(4-methyl-1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 352678-49-0C20H14BrN3OS
Ethyl 2-[[2-(3,4-dimethoxyphenyl)quinoline-4-carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C25H23N3O5S, CAS 361982-90-3
Ethyl 2-[[2-(3,4-dimethoxyphenyl)quinoline-4-carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate
CAS 361982-90-3C25H23N3O5S
2-(3-Bromophenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C19H12BrN3OS, CAS 353472-29-4
2-(3-Bromophenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 353472-29-4C19H12BrN3OS
2-(4-Ethylphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C21H17N3OS, CAS 352691-56-6
2-(4-Ethylphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 352691-56-6C21H17N3OS
2-(3-Methoxyphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C20H15N3O2S, CAS 353775-29-8
2-(3-Methoxyphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 353775-29-8C20H15N3O2S
N-(4-tert-Butyl-1,3-thiazol-2-yl)-2-phenylquinoline-4-carboxamide chemical structure, C23H21N3OS, CAS 397276-71-0
N-(4-tert-Butyl-1,3-thiazol-2-yl)-2-phenylquinoline-4-carboxamide
CAS 397276-71-0C23H21N3OS
Ethyl (2-{[(2-phenylquinolin-4-yl)carbonyl]amino}-1,3-thiazol-4-yl)acetate chemical structure, C23H19N3O3S, CAS 315679-49-3
Ethyl (2-{[(2-phenylquinolin-4-yl)carbonyl]amino}-1,3-thiazol-4-yl)acetate
CAS 315679-49-3C23H19N3O3S
2-(4-Methoxyphenyl)-N-(5-methyl-1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C21H17N3O2S, CAS 784159-78-0
2-(4-Methoxyphenyl)-N-(5-methyl-1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 784159-78-0C21H17N3O2S
2-(3,4-Dimethoxyphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C21H17N3O3S, CAS 438472-09-4
2-(3,4-Dimethoxyphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 438472-09-4C21H17N3O3S
Methyl 2-({[2-(3-chlorophenyl)quinolin-4-yl]carbonyl}amino)-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C22H16ClN3O3S, CAS 777871-46-2
Methyl 2-({[2-(3-chlorophenyl)quinolin-4-yl]carbonyl}amino)-4-methyl-1,3-thiazole-5-carboxylate
CAS 777871-46-2C22H16ClN3O3S
2-(4-Fluorophenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C19H12FN3OS, CAS 327086-59-9
2-(4-Fluorophenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 327086-59-9C19H12FN3OS
Ethyl 2-(2-phenylquinoline-4-carboxamido)thiazole-4-carboxylate chemical structure, C22H17N3O3S, CAS 361168-22-1
Ethyl 2-(2-phenylquinoline-4-carboxamido)thiazole-4-carboxylate
CAS 361168-22-1C22H17N3O3S
2-(3,4-Dimethoxyphenyl)-N-(4-methyl-1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C22H19N3O3S, CAS 544697-54-3
2-(3,4-Dimethoxyphenyl)-N-(4-methyl-1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 544697-54-3C22H19N3O3S
2-(4-Methoxyphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C20H15N3O2S, CAS 540796-46-1
2-(4-Methoxyphenyl)-N-(1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 540796-46-1C20H15N3O2S
Ethyl 2-[[2-(4-chlorophenyl)quinoline-4-carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate chemical structure, C23H18ClN3O3S, CAS 362473-72-1
Ethyl 2-[[2-(4-chlorophenyl)quinoline-4-carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylate
CAS 362473-72-1C23H18ClN3O3S
2-(3,4-Dimethoxyphenyl)-N-(4,5-dimethyl-1,3-thiazol-2-yl)quinoline-4-carboxamide chemical structure, C23H21N3O3S, CAS 355384-15-5
2-(3,4-Dimethoxyphenyl)-N-(4,5-dimethyl-1,3-thiazol-2-yl)quinoline-4-carboxamide
CAS 355384-15-5C23H21N3O3S
N-(5-Nitro-2-thiazolyl)-2-phenylquinoline-4-carboxamide chemical structure, C19H12N4O3S, CAS 349400-40-4
N-(5-Nitro-2-thiazolyl)-2-phenylquinoline-4-carboxamide
CAS 349400-40-4C19H12N4O3S