Murcko scaffold
3-(Benzyloxy)thiophene scaffold
85 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 85
- With full pages
- 15
Scaffold SMILES
c1ccc(COc2ccsc2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 85 chemicals
![Methyl 3-[(4-fluorobenzyl)oxy]-2-thiophenecarboxylate chemical structure, C13H11FO3S, CAS 338417-95-1](/s/RAUPKWHRUCKBSO-UHFFFAOYSA-N.svg)
Methyl 3-[(4-fluorobenzyl)oxy]-2-thiophenecarboxylate
CAS 338417-95-1C13H11FO3S
![3-[(2,4-Dichlorophenyl)methoxy]thiophene-2-carbohydrazide chemical structure, C12H10Cl2N2O2S, CAS 343375-83-7](/s/PKSTWWPZBLDSBW-UHFFFAOYSA-N.svg)
3-[(2,4-Dichlorophenyl)methoxy]thiophene-2-carbohydrazide
CAS 343375-83-7C12H10Cl2N2O2S
![2-{[3-(Benzyloxy)-2-thienyl]carbonyl}-N-methyl-1-hydrazinecarbothioamide chemical structure, C14H15N3O2S2, CAS 343375-84-8](/s/LCZZWSMCVJSALU-UHFFFAOYSA-N.svg)
2-{[3-(Benzyloxy)-2-thienyl]carbonyl}-N-methyl-1-hydrazinecarbothioamide
CAS 343375-84-8C14H15N3O2S2
![N-Methyl-2-({3-[(4-methylbenzyl)oxy]-2-thienyl}carbonyl)-1-hydrazinecarbothioamide chemical structure, C15H17N3O2S2, CAS 343375-85-9](/s/ZISZGSDLAXWZND-UHFFFAOYSA-N.svg)
N-Methyl-2-({3-[(4-methylbenzyl)oxy]-2-thienyl}carbonyl)-1-hydrazinecarbothioamide
CAS 343375-85-9C15H17N3O2S2
![2-({3-[(2,4-Dichlorobenzyl)oxy]-2-thienyl}carbonyl)-N-methyl-1-hydrazinecarbothioamide chemical structure, C14H13Cl2N3O2S2, CAS 343375-86-0](/s/GRQGYFLPOJDQAT-UHFFFAOYSA-N.svg)
2-({3-[(2,4-Dichlorobenzyl)oxy]-2-thienyl}carbonyl)-N-methyl-1-hydrazinecarbothioamide
CAS 343375-86-0C14H13Cl2N3O2S2
![3-[(4-Methylbenzyl)oxy]-2-thiophenecarboxylic acid chemical structure, C13H12O3S, CAS 343375-89-3](/s/MYVLJSQSMBUIJV-UHFFFAOYSA-N.svg)
3-[(4-Methylbenzyl)oxy]-2-thiophenecarboxylic acid
CAS 343375-89-3C13H12O3S
![2-({3-[(4-Methylbenzyl)oxy]-2-thienyl}carbonyl)-1-hydrazinecarbothioamide chemical structure, C14H15N3O2S2, CAS 343375-97-3](/s/MTNMOZVPZJGTNU-UHFFFAOYSA-N.svg)
2-({3-[(4-Methylbenzyl)oxy]-2-thienyl}carbonyl)-1-hydrazinecarbothioamide
CAS 343375-97-3C14H15N3O2S2
![3-{[3-(Trifluoromethyl)benzyl]oxy}-2-thiophenecarbohydrazide chemical structure, C13H11F3N2O2S, CAS 343376-03-4](/s/QCZYAFUFZRQIOK-UHFFFAOYSA-N.svg)
3-{[3-(Trifluoromethyl)benzyl]oxy}-2-thiophenecarbohydrazide
CAS 343376-03-4C13H11F3N2O2S
![N-Methyl-2-[(3-{[3-(trifluoromethyl)benzyl]oxy}-2-thienyl)carbonyl]-1-hydrazinecarbothioamide chemical structure, C15H14F3N3O2S2, CAS 343376-09-0](/s/FGFQTLDILPRZDZ-UHFFFAOYSA-N.svg)
N-Methyl-2-[(3-{[3-(trifluoromethyl)benzyl]oxy}-2-thienyl)carbonyl]-1-hydrazinecarbothioamide
CAS 343376-09-0C15H14F3N3O2S2
![Methyl 5-methoxy-3-[(4-methylbenzyl)oxy]-2-thiophenecarboxylate chemical structure, C15H16O4S, CAS 343376-14-7](/s/BBYYTESCDJZNAO-UHFFFAOYSA-N.svg)
Methyl 5-methoxy-3-[(4-methylbenzyl)oxy]-2-thiophenecarboxylate
CAS 343376-14-7C15H16O4S
![2-[(3-{[3-(Trifluoromethyl)benzyl]oxy}-2-thienyl)carbonyl]-1-hydrazinecarbothioamide chemical structure, C14H12F3N3O2S2, CAS 343376-15-8](/s/XCNDJSMOLQXLKL-UHFFFAOYSA-N.svg)
2-[(3-{[3-(Trifluoromethyl)benzyl]oxy}-2-thienyl)carbonyl]-1-hydrazinecarbothioamide
CAS 343376-15-8C14H12F3N3O2S2
![2-({3-[(2,4-Dichlorobenzyl)oxy]-2-thienyl}carbonyl)-1-hydrazinecarbothioamide chemical structure, C13H11Cl2N3O2S2, CAS 343376-20-5](/s/KULMQINGVKGXDD-UHFFFAOYSA-N.svg)
2-({3-[(2,4-Dichlorobenzyl)oxy]-2-thienyl}carbonyl)-1-hydrazinecarbothioamide
CAS 343376-20-5C13H11Cl2N3O2S2
![Methyl N-{3-[(4-chlorobenzyl)oxy]-2-thienyl}carbamate chemical structure, C13H12ClNO3S, CAS 339009-49-3](/s/HYAHSLXOSUMVDM-UHFFFAOYSA-N.svg)
Methyl N-{3-[(4-chlorobenzyl)oxy]-2-thienyl}carbamate
CAS 339009-49-3C13H12ClNO3S
![Methyl N-(3-{[3-(trifluoromethyl)benzyl]oxy}-2-thienyl)carbamate chemical structure, C14H12F3NO3S, CAS 339009-54-0](/s/LOZGNLPQNJMONY-UHFFFAOYSA-N.svg)
Methyl N-(3-{[3-(trifluoromethyl)benzyl]oxy}-2-thienyl)carbamate
CAS 339009-54-0C14H12F3NO3S
![Methyl 3-{[4-(tert-butyl)benzyl]oxy}-2-thiophenecarboxylate chemical structure, C17H20O3S, CAS 344268-04-8](/s/LKKXPHJSDLRQPF-UHFFFAOYSA-N.svg)
Methyl 3-{[4-(tert-butyl)benzyl]oxy}-2-thiophenecarboxylate
CAS 344268-04-8C17H20O3S
![3-[(4-tert-Butylphenyl)methoxy]thiophene-2-carboxylic acid chemical structure, C16H18O3S, CAS 344268-35-5](/s/XEHCQEAFPAXMLR-UHFFFAOYSA-N.svg)
3-[(4-tert-Butylphenyl)methoxy]thiophene-2-carboxylic acid
CAS 344268-35-5C16H18O3S
![Methyl 3-[(2,6-dichlorophenyl)methoxy]thiophene-2-carboxylate chemical structure, C13H10Cl2O3S, CAS 344268-42-4](/s/ILGCNYRKWWXTDO-UHFFFAOYSA-N.svg)
Methyl 3-[(2,6-dichlorophenyl)methoxy]thiophene-2-carboxylate
CAS 344268-42-4C13H10Cl2O3S
![2-{[3-(Benzyloxy)-2-thienyl]carbonyl}-1-hydrazinecarbothioamide chemical structure, C13H13N3O2S2, CAS 339022-29-6](/s/IIIIJONYUCLKDU-UHFFFAOYSA-N.svg)
2-{[3-(Benzyloxy)-2-thienyl]carbonyl}-1-hydrazinecarbothioamide
CAS 339022-29-6C13H13N3O2S2
![Methyl 3-[(4-methoxybenzyl)oxy]-2-thiophenecarboxylate chemical structure, C14H14O4S, CAS 339098-23-6](/s/LQWNIDRBNIHBFV-UHFFFAOYSA-N.svg)
Methyl 3-[(4-methoxybenzyl)oxy]-2-thiophenecarboxylate
CAS 339098-23-6C14H14O4S
Methyl 3-(benzyloxy)-2-thiophenecarboxylate
CAS 186588-84-1C13H12O3S
![Methyl 3-[(4-methylphenyl)methoxy]thiophene-2-carboxylate chemical structure, C14H14O3S, CAS 343375-77-9](/s/SBCZDOVUDWGMEG-UHFFFAOYSA-N.svg)
Methyl 3-[(4-methylphenyl)methoxy]thiophene-2-carboxylate
CAS 343375-77-9C14H14O3S
![Methyl 3-[(2,4-dichlorobenzyl)oxy]-2-thiophenecarboxylate chemical structure, C13H10Cl2O3S, CAS 343375-78-0](/s/RJOPYEKBTLPHSE-UHFFFAOYSA-N.svg)
Methyl 3-[(2,4-dichlorobenzyl)oxy]-2-thiophenecarboxylate
CAS 343375-78-0C13H10Cl2O3S
3-(Benzyloxy)thiophene-2-carbohydrazide
CAS 343375-80-4C12H12N2O2S
3-((4-Methylbenzyl)oxy)thiophene-2-carbohydrazide
CAS 343375-82-6C13H14N2O2S
- 3-[(2,4-Dichlorophenyl)methoxy]thiophene-2-carboxylic acid343376-05-6C12H8Cl2O3S
- 3-[(4-Chlorobenzyl)oxy]-2-thiophenecarbohydrazide339009-44-8C12H11ClN2O2S
- 3-[(4-Chlorobenzyl)oxy]-2-thiophenecarboxylic acid339009-58-4C12H9ClO3S
- 3-[(4-Fluorophenyl)methoxy]thiophene-2-carboxylic acid303147-78-6C12H9FO3S
- 3-(Benzyloxy)-2-thiophenecarboxylic acid186588-88-5C12H10O3S
- 3-[(4-Fluorobenzyl)oxy]-2-thiophenecarbohydrazide338751-50-1C12H11FN2O2S
- Methyl 3-{[3-(trifluoromethyl)benzyl]oxy}-2-thiophenecarboxylate343375-98-4C14H11F3O3S
- 3-{[3-(Trifluoromethyl)benzyl]oxy}-2-thiophenecarboxylic acid339009-59-5C13H9F3O3S
- Methyl 3-[(4-chlorobenzyl)oxy]-2-thiophenecarboxylate339009-41-5C13H11ClO3S
- Methyl 3-[(3-methoxyphenyl)methoxy]thiophene-2-carboxylate866154-74-7C14H14O4S
- Methyl 3-[(4-bromobenzyl)oxy]-2-thiophenecarboxylate866009-00-9C13H11BrO3S
- 3-[(2,4-Dichlorophenyl)methoxy]thiophene-2-carbonyl azide956500-91-7C12H7Cl2N3O2S
- Methyl (3-benzyloxy-5-trifluoromethylthien-2-yl)-carboxylate217959-86-9C14H11F3O3S
- 3-(Benzyloxy)-5-methylthiophene-2-carboxylic acid113589-53-0C13H12O3S
- 3-(Benzyloxy)thiophene125300-72-3C11H10OS
- 3-Benzyloxy-5-isopropyl-thiophene-2-carboxylic acid647833-89-4C15H16O3S
- 1-[3-(Benzyloxy)-2-thienyl]ethanone406212-44-0C13H12O2S
- 3-(Benzyloxy)-N-methoxy-N-methyl-2-thiophenecarboxamide406212-43-9C14H15NO3S
- (R)-Methyl 5-amino-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate929039-92-9C15H14F3NO3S
- [3-(Benzyloxy)thien-2-yl]methanol1030012-41-9C12H12O2S
- (R)-Methyl 5-nitro-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate929039-94-1C15H12F3NO5S
- Methyl 3-(1-(2-chlorophenyl)ethoxy)thiophene-2-carboxylate886856-53-7C14H13ClO3S
- 5-Bromo-3-[1-(2-chloro-phenyl)-ethoxy]-thiophene-2-carboxylic acid methyl ester945256-26-8C14H12BrClO3S
- 3-((2-Chlorobenzyl)oxy)thiophene-2-carboxylic acid1285223-04-2C12H9ClO3S
Related scaffolds
Same ring framework with different atoms or bond orders
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O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1cccs1)c1ccccc152 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
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c1ccc(CSc2nncs2)cc144 chemicals