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Murcko scaffold

Ring system with 5 rings and 27 atoms

51 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
27
Chemicals
51
With full pages
3
Scaffold SMILES

O=C(NC1CCc2ccccc21)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCc2ccccc21)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 51 chemicals

Rel-(1R)-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C25H21NO4, CAS 2757698-10-3
Rel-(1R)-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 2757698-10-3C25H21NO4
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C25H21NO4, CAS 214139-28-3
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 214139-28-3C25H21NO4
rac-(1R,2R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid chemical structure, C25H21NO4, CAS 2307772-75-2
rac-(1R,2R)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid
CAS 2307772-75-2C25H21NO4
(9H-Fluoren-9-yl)methyl N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamate chemical structure, C24H21NO3, CAS 1001067-21-5
(9H-Fluoren-9-yl)methyl N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamate
CAS 1001067-21-5C24H21NO3
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-2-carboxylic acid chemical structure, C25H21NO4, CAS 1822815-26-8
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-2-carboxylic acid
CAS 1822815-26-8C25H21NO4
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C26H23NO4, CAS 1700410-21-4
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 1700410-21-4C26H23NO4
(9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamate chemical structure, C24H21NO3, CAS 1391522-95-4
(9H-Fluoren-9-yl)methyl N-[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamate
CAS 1391522-95-4C24H21NO3
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-6-methoxy-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C26H23NO5, CAS 1701855-17-5
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-6-methoxy-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 1701855-17-5C26H23NO5
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-fluoro-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C25H20FNO4, CAS 1695234-55-9
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-fluoro-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 1695234-55-9C25H20FNO4
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-fluoro-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C25H20FNO4, CAS 1696905-09-5
1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-fluoro-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 1696905-09-5C25H20FNO4
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-methoxy-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C26H23NO5, CAS 2094568-26-8
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-methoxy-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 2094568-26-8C26H23NO5
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(propan-2-yl)-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C28H27NO4, CAS 2138342-05-7
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(propan-2-yl)-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 2138342-05-7C28H27NO4
rac-(1R,3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C25H21NO4, CAS 2137786-49-1
rac-(1R,3S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 2137786-49-1C25H21NO4
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-2,2-dimethyl-1,3-dihydroindene-5-carboxylic acid chemical structure, C27H25NO4, CAS 2413877-62-8
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-2,2-dimethyl-1,3-dihydroindene-5-carboxylic acid
CAS 2413877-62-8C27H25NO4
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-2,3-dihydro-1H-indene-4-carboxylic acid chemical structure, C25H21NO4, CAS 2445793-82-6
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-2,3-dihydro-1H-indene-4-carboxylic acid
CAS 2445793-82-6C25H21NO4
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-2,3-dihydro-1H-indene-5-carboxylic acid chemical structure, C25H21NO4, CAS 2490375-74-9
1-(9H-Fluoren-9-ylmethoxycarbonylamino)-2,3-dihydro-1H-indene-5-carboxylic acid
CAS 2490375-74-9C25H21NO4
4-Bromo-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-fluoro-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C25H19BrFNO4, CAS 2137691-97-3
4-Bromo-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-fluoro-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 2137691-97-3C25H19BrFNO4
4-[(3-{[(tert-Butoxy)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl)({[(9H-fluoren-9-yl)methoxy]carbonyl})amino]butanoic acid chemical structure, C33H36N2O6, CAS 2138122-77-5
4-[(3-{[(tert-Butoxy)carbonyl]amino}-2,3-dihydro-1H-inden-1-yl)({[(9H-fluoren-9-yl)methoxy]carbonyl})amino]butanoic acid
CAS 2138122-77-5C33H36N2O6
rac-(1R,2R)-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methyl-2,3-dihydro-1H-indene-2-carboxylic acid chemical structure, C26H23NO4, CAS 2228020-91-3
rac-(1R,2R)-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methyl-2,3-dihydro-1H-indene-2-carboxylic acid
CAS 2228020-91-3C26H23NO4
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-1-carboxylic acid chemical structure, C25H21NO4, CAS 617713-11-8
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-1-carboxylic acid
CAS 617713-11-8C25H21NO4
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-4-carboxylic acid chemical structure, C25H21NO4, CAS 2225146-32-5
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-4-carboxylic acid
CAS 2225146-32-5C25H21NO4
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-6-fluoro-2,3-dihydro-1H-indene-4-carboxylic acid chemical structure, C25H20FNO4, CAS 2757959-87-6
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-6-fluoro-2,3-dihydro-1H-indene-4-carboxylic acid
CAS 2757959-87-6C25H20FNO4
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-5-carboxylic acid chemical structure, C25H21NO4, CAS 2580250-37-7
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,3-dihydro-1H-indene-5-carboxylic acid
CAS 2580250-37-7C25H21NO4
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid chemical structure, C25H21NO5, CAS 2580255-15-6
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-4-hydroxy-2,3-dihydro-1H-indene-2-carboxylic acid
CAS 2580255-15-6C25H21NO5