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Murcko scaffold

Ring system with 4 rings and 25 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
11
With full pages
6
Scaffold SMILES

O=C1Nc2ccccc2C1=C1SC(=S)N(CCc2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C1=C1SC(=S)N(CCc2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

(3Z)-3-{3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene}-1-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C22H20N2O4S2, CAS 324564-55-8
(3Z)-3-{3-[2-(3,4-Dimethoxyphenyl)ethyl]-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene}-1-methyl-1,3-dihydro-2H-indol-2-one
CAS 324564-55-8C22H20N2O4S2
(3Z)-1-Butyl-3-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C23H22N2O2S2, CAS 324561-56-0
(3Z)-1-Butyl-3-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 324561-56-0C23H22N2O2S2
(3Z)-1-Methyl-3-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C20H16N2O2S2, CAS 324543-82-0
(3Z)-1-Methyl-3-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 324543-82-0C20H16N2O2S2
(5Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-(2-oxo-1-propylindol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C24H24N2O4S2, CAS 324564-80-9
(5Z)-3-[2-(3,4-Dimethoxyphenyl)ethyl]-5-(2-oxo-1-propylindol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 324564-80-9C24H24N2O4S2
(3Z)-5-Bromo-1-ethyl-3-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C21H17BrN2O2S2, CAS 617697-75-3
(3Z)-5-Bromo-1-ethyl-3-[4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 617697-75-3C21H17BrN2O2S2
(3Z)-5-Bromo-3-{3-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene}-1-ethyl-1,3-dihydro-2H-indol-2-one chemical structure, C23H21BrN2O4S2, CAS 617697-86-6
(3Z)-5-Bromo-3-{3-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene}-1-ethyl-1,3-dihydro-2H-indol-2-one
CAS 617697-86-6C23H21BrN2O4S2
(3Z)-5-Bromo-3-{3-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene}-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C24H23BrN2O4S2, CAS 617696-63-6
(3Z)-5-Bromo-3-{3-[2-(3,4-dimethoxyphenyl)ethyl]-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene}-1-propyl-1,3-dihydro-2H-indol-2-one
CAS 617696-63-6C24H23BrN2O4S2
(3Z)-5-Bromo-1-butyl-3-{3-[2-(4-methoxyphenyl)ethyl]-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene}-1,3-dihydro-2H-indol-2-one chemical structure, C24H23BrN2O3S2, CAS 618075-28-8
(3Z)-5-Bromo-1-butyl-3-{3-[2-(4-methoxyphenyl)ethyl]-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene}-1,3-dihydro-2H-indol-2-one
CAS 618075-28-8C24H23BrN2O3S2
(3Z)-5-Bromo-1-butyl-3-(4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C23H21BrN2O2S2, CAS 618075-20-0
(3Z)-5-Bromo-1-butyl-3-(4-oxo-3-(2-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 618075-20-0C23H21BrN2O2S2
(3Z)-5-Bromo-1-butyl-3-(3-(2-(3,4-dimethoxyphenyl)ethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C25H25BrN2O4S2, CAS 618081-28-0
(3Z)-5-Bromo-1-butyl-3-(3-(2-(3,4-dimethoxyphenyl)ethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 618081-28-0C25H25BrN2O4S2
(Z)-5-(1-Allyl-2-oxoindolin-3-ylidene)-3-(4-methoxyphenethyl)-2-thioxothiazolidin-4-one chemical structure, C23H20N2O3S2, CAS 538340-50-0
(Z)-5-(1-Allyl-2-oxoindolin-3-ylidene)-3-(4-methoxyphenethyl)-2-thioxothiazolidin-4-one
CAS 538340-50-0C23H20N2O3S2