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Murcko scaffold

Ring system with 4 rings and 22 atoms

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
13
With full pages
4
Scaffold SMILES

c1ccc(COc2csc(-n3cnc4ccccc43)c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(COc2csc(-n3cnc4ccccc43)c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

RefChem:783291 chemical structure, C22H18F3N3O4S, CAS 660868-91-7
RefChem:783291
CAS 660868-91-7C22H18F3N3O4S
3-[(2-Bromophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide chemical structure, C21H18BrN3O4S, CAS 660868-93-9
3-[(2-Bromophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide
CAS 660868-93-9C21H18BrN3O4S
Gsk-319347A chemical structure, C22H19N3O5S2, CAS 862812-98-4
Gsk-319347A
CAS 862812-98-4C22H19N3O5S2
5-(5,6-Bis(methyloxy)-1H-benzimidazol-1-yl)-3-((1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxamide chemical structure, C22H20ClN3O4S, CAS 862813-28-3
5-(5,6-Bis(methyloxy)-1H-benzimidazol-1-yl)-3-((1-(2-chlorophenyl)ethyl)oxy)-2-thiophenecarboxamide
CAS 862813-28-3C22H20ClN3O4S
5-(5,6-Dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-methanesulfonylphenyl)methoxy]thiophene-2-carboxylicacid chemical structure, C22H20N2O7S2, CAS 1007698-63-6
5-(5,6-Dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-methanesulfonylphenyl)methoxy]thiophene-2-carboxylicacid
CAS 1007698-63-6C22H20N2O7S2
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide chemical structure, C22H21N3O6S2, CAS 916985-21-2
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide
CAS 916985-21-2C22H21N3O6S2
Benzimidazole-thiophene carbonitrile, 3 chemical structure, C22H19N3O5S2, CAS 916985-22-3
Benzimidazole-thiophene carbonitrile, 3
CAS 916985-22-3C22H19N3O5S2
3-[(2-Bromophenyl)methoxy]-5-[6-(trifluoromethyl)benzimidazol-1-yl]thiophene-2-carboxamide chemical structure, C20H13BrF3N3O2S, CAS 660869-54-5
3-[(2-Bromophenyl)methoxy]-5-[6-(trifluoromethyl)benzimidazol-1-yl]thiophene-2-carboxamide
CAS 660869-54-5C20H13BrF3N3O2S
Methyl 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[(2-trifluoromethylbenzyl)-oxy]thiophene-2-carboxylate chemical structure, C23H19F3N2O5S, CAS 660868-83-7
Methyl 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[(2-trifluoromethylbenzyl)-oxy]thiophene-2-carboxylate
CAS 660868-83-7C23H19F3N2O5S
2-Thiophenecarboxamide, 5-(1H-benzimidazol-1-yl)-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]- chemical structure, C21H16F3N3O2S, CAS 1276687-55-8
2-Thiophenecarboxamide, 5-(1H-benzimidazol-1-yl)-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]-
CAS 1276687-55-8C21H16F3N3O2S
(R)-Methyl 5-(6-(chloromethyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate chemical structure, C23H18ClF3N2O3S, CAS 929095-40-9
(R)-Methyl 5-(6-(chloromethyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate
CAS 929095-40-9C23H18ClF3N2O3S
(R)-Methyl 5-(6-(hydroxymethyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate chemical structure, C23H19F3N2O4S, CAS 929095-39-6
(R)-Methyl 5-(6-(hydroxymethyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate
CAS 929095-39-6C23H19F3N2O4S
(R)-Methyl 5-(6-(pivaloyloxymethyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate chemical structure, C28H27F3N2O5S, CAS 929095-38-5
(R)-Methyl 5-(6-(pivaloyloxymethyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxylate
CAS 929095-38-5C28H27F3N2O5S