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Murcko scaffold

[1,3]Dioxolo[4,5-g]quinoline scaffold

45 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
13
Chemicals
45
With full pages
3
Scaffold SMILES

c1cnc2cc3c(cc2c1)OCO3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the [1,3]Dioxolo[4,5-g]quinoline page
Murcko scaffold c1cnc2cc3c(cc2c1)OCO3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 45 of 45 chemicals

8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline chemical structure, C11H8ClNO2, CAS 50593-65-2
8-Chloro-6-methyl-[1,3]dioxolo[4,5-g]quinoline
CAS 50593-65-2C11H8ClNO2
8-Hydrazinyl-6-methyl-2H-[1,3]dioxolo[4,5-g]quinoline chemical structure, C11H11N3O2, CAS 91918-90-0
8-Hydrazinyl-6-methyl-2H-[1,3]dioxolo[4,5-g]quinoline
CAS 91918-90-0C11H11N3O2
1,3-Dioxolo(4,5-g)quinoline-7-carboxylic acid, 8-chloro-, ethyl ester chemical structure, C13H10ClNO4, CAS 26893-17-4
1,3-Dioxolo(4,5-g)quinoline-7-carboxylic acid, 8-chloro-, ethyl ester
CAS 26893-17-4C13H10ClNO4
6-Chloro-[1,3]dioxolo[4,5-g]quinoline-7-carbaldehyde chemical structure, C11H6ClNO3, CAS 332382-81-7
6-Chloro-[1,3]dioxolo[4,5-g]quinoline-7-carbaldehyde
CAS 332382-81-7C11H6ClNO3
6,7-Dimethyl 8-methyl-1,3-dioxolo(4,5-g)quinoline-6,7-dicarboxylate chemical structure, C15H13NO6, CAS 861210-50-6
6,7-Dimethyl 8-methyl-1,3-dioxolo(4,5-g)quinoline-6,7-dicarboxylate
CAS 861210-50-6C15H13NO6
6,8-Dimethyl-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid chemical structure, C13H11NO4, CAS 561010-53-5
6,8-Dimethyl-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
CAS 561010-53-5C13H11NO4
N-[(6-Chloro-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]-N-(2-methoxyethyl)acetamide chemical structure, C16H17ClN2O4, CAS 606104-30-7
N-[(6-Chloro-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]-N-(2-methoxyethyl)acetamide
CAS 606104-30-7C16H17ClN2O4
N-[(6-Chloro[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]-2-methoxy-N-(2-methoxyethyl)acetamide chemical structure, C17H19ClN2O5, CAS 606104-76-1
N-[(6-Chloro[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]-2-methoxy-N-(2-methoxyethyl)acetamide
CAS 606104-76-1C17H19ClN2O5
Dimethyl [1,3]dioxolo[4,5-g]quinoline-6,7-dicarboxylate chemical structure, C14H11NO6, CAS 7509-45-7
Dimethyl [1,3]dioxolo[4,5-g]quinoline-6,7-dicarboxylate
CAS 7509-45-7C14H11NO6
N-[(6-Chloro[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]-2,2,2-trifluoro-N-(2-methoxyethyl)acetamide chemical structure, C16H14ClF3N2O4, CAS 606104-80-7
N-[(6-Chloro[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl]-2,2,2-trifluoro-N-(2-methoxyethyl)acetamide
CAS 606104-80-7C16H14ClF3N2O4
2-{[8-(Trifluoromethyl)-2H-[1,3]dioxolo[4,5-G]quinolin-6-yl]sulfanyl}acetamide chemical structure, C13H9F3N2O3S, CAS 712295-55-1
2-{[8-(Trifluoromethyl)-2H-[1,3]dioxolo[4,5-G]quinolin-6-yl]sulfanyl}acetamide
CAS 712295-55-1C13H9F3N2O3S
Ethyl 8-azido-2H-[1,3]dioxolo[4,5-G]quinoline-7-carboxylate chemical structure, C13H10N4O4, CAS 5244-89-3
Ethyl 8-azido-2H-[1,3]dioxolo[4,5-G]quinoline-7-carboxylate
CAS 5244-89-3C13H10N4O4
6-Amino[1,3]dioxolo[4,5-g]quinoline-7-carboxamide chemical structure, C11H9N3O3, CAS 55149-47-8
6-Amino[1,3]dioxolo[4,5-g]quinoline-7-carboxamide
CAS 55149-47-8C11H9N3O3
N'-(6,7-Methylenedioxyquinolin-4-yl)-N,N-dimethylethane-1,2-diamine chemical structure, C14H17N3O2, CAS 500214-39-1
N'-(6,7-Methylenedioxyquinolin-4-yl)-N,N-dimethylethane-1,2-diamine
CAS 500214-39-1C14H17N3O2
1,3-Dioxolo[4,5-g]quinoline-7-carbonitrile, 6-amino- chemical structure, C11H7N3O2, CAS 209533-66-4
1,3-Dioxolo[4,5-g]quinoline-7-carbonitrile, 6-amino-
CAS 209533-66-4C11H7N3O2
6-Chloro-8-methyl-7-vinyl-[1,3]dioxolo[4,5-g]quinoline chemical structure, C13H10ClNO2, CAS 62452-24-8
6-Chloro-8-methyl-7-vinyl-[1,3]dioxolo[4,5-g]quinoline
CAS 62452-24-8C13H10ClNO2
Ethyl 8-ethoxy-2H-[1,3]dioxolo[4,5-G]quinoline-7-carboxylate chemical structure, C15H15NO5, CAS 33331-61-2
Ethyl 8-ethoxy-2H-[1,3]dioxolo[4,5-G]quinoline-7-carboxylate
CAS 33331-61-2C15H15NO5
8-Chloro-[1,3]dioxolo[4,5-g]quinoline chemical structure, C10H6ClNO2, CAS 59134-89-3
8-Chloro-[1,3]dioxolo[4,5-g]quinoline
CAS 59134-89-3C10H6ClNO2
Methyl 2-((8-(trifluoromethyl)-[1,3]dioxolo[4,5-g]quinolin-6-yl)thio)acetate chemical structure, C14H10F3NO4S, CAS 881077-19-6
Methyl 2-((8-(trifluoromethyl)-[1,3]dioxolo[4,5-g]quinolin-6-yl)thio)acetate
CAS 881077-19-6C14H10F3NO4S
[1,3]Dioxolo[4,5-g]quinoline-7-carboxylic acid chemical structure, C11H7NO4, CAS 26893-31-2
[1,3]Dioxolo[4,5-g]quinoline-7-carboxylic acid
CAS 26893-31-2C11H7NO4
6-Chloro-[1,3]dioxolo[4,5-g]quinoline-7-carbonitrile chemical structure, C11H5ClN2O2, CAS 1017355-65-5
6-Chloro-[1,3]dioxolo[4,5-g]quinoline-7-carbonitrile
CAS 1017355-65-5C11H5ClN2O2
[1,3]Dioxolo[4,5-g]quinoline chemical structure, C10H7NO2, CAS 269-51-2
[1,3]Dioxolo[4,5-g]quinoline
CAS 269-51-2C10H7NO2
8-Chloro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid chemical structure, C11H6ClNO4, CAS 26893-32-3
8-Chloro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid
CAS 26893-32-3C11H6ClNO4
8-Methyl-[1,3]dioxolo[4,5-g]quinoline chemical structure, C11H9NO2, CAS 51048-62-5
8-Methyl-[1,3]dioxolo[4,5-g]quinoline
CAS 51048-62-5C11H9NO2