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Murcko scaffold

Ring system with 3 rings and 21 atoms

32 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
32
With full pages
11
Scaffold SMILES

O=C(Cn1ncc2ccccc2c1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1ncc2ccccc2c1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

4-[2-(4-Methyl-1-oxo-1H-phthalazin-2-yl)-acetylamino]-benzoic acid methyl ester chemical structure, C19H17N3O4, CAS 350713-56-3
4-[2-(4-Methyl-1-oxo-1H-phthalazin-2-yl)-acetylamino]-benzoic acid methyl ester
CAS 350713-56-3C19H17N3O4
N-(2,5-Dimethylphenyl)-2-(4-methyl-1-oxophthalazin-2-yl)acetamide chemical structure, C19H19N3O2, CAS 354990-80-0
N-(2,5-Dimethylphenyl)-2-(4-methyl-1-oxophthalazin-2-yl)acetamide
CAS 354990-80-0C19H19N3O2
N-(4-Hydroxyphenyl)-2-(4-methyl-1-oxophthalazin-2(1H)-yl)acetamide chemical structure, C17H15N3O3, CAS 354990-82-2
N-(4-Hydroxyphenyl)-2-(4-methyl-1-oxophthalazin-2(1H)-yl)acetamide
CAS 354990-82-2C17H15N3O3
N-(4-Methoxyphenyl)-2-(4-methyl-1-oxophthalazin-2-yl)acetamide chemical structure, C18H17N3O3, CAS 352219-88-6
N-(4-Methoxyphenyl)-2-(4-methyl-1-oxophthalazin-2-yl)acetamide
CAS 352219-88-6C18H17N3O3
2-(4-Methyl-1-oxophthalazin-2-yl)-N-phenylacetamide chemical structure, C17H15N3O2, CAS 68775-85-9
2-(4-Methyl-1-oxophthalazin-2-yl)-N-phenylacetamide
CAS 68775-85-9C17H15N3O2
N-(3-Hydroxyphenyl)-2-(4-methyl-1-oxophthalazin-2-yl)acetamide chemical structure, C17H15N3O3, CAS 354539-85-8
N-(3-Hydroxyphenyl)-2-(4-methyl-1-oxophthalazin-2-yl)acetamide
CAS 354539-85-8C17H15N3O3
N-(4-Fluorophenyl)-2-(4-methyl-1-oxophthalazin-2-yl)acetamide chemical structure, C17H14FN3O2, CAS 684234-83-1
N-(4-Fluorophenyl)-2-(4-methyl-1-oxophthalazin-2-yl)acetamide
CAS 684234-83-1C17H14FN3O2
2-(1-Oxophthalazin-2-yl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C17H12F3N3O2, CAS 670240-77-4
2-(1-Oxophthalazin-2-yl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 670240-77-4C17H12F3N3O2
N-(3-Nitrophenyl)-2-(1-oxophthalazin-2-yl)acetamide chemical structure, C16H12N4O4, CAS 672899-34-2
N-(3-Nitrophenyl)-2-(1-oxophthalazin-2-yl)acetamide
CAS 672899-34-2C16H12N4O4
2-(4-Methyl-1-oxophthalazin-2-yl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C18H14F3N3O2, CAS 684234-86-4
2-(4-Methyl-1-oxophthalazin-2-yl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 684234-86-4C18H14F3N3O2
N-(3-Bromophenyl)-4-methyl-1-oxo-2(1H)-phthalazineacetamide chemical structure, C17H14BrN3O2, CAS 444935-90-4
N-(3-Bromophenyl)-4-methyl-1-oxo-2(1H)-phthalazineacetamide
CAS 444935-90-4C17H14BrN3O2
N,N-Dimethyl-4-[[2-(4-methyl-1-oxophthalazin-2-yl)acetyl]amino]benzamide chemical structure, C20H20N4O3, CAS 684234-87-5
N,N-Dimethyl-4-[[2-(4-methyl-1-oxophthalazin-2-yl)acetyl]amino]benzamide
CAS 684234-87-5C20H20N4O3
N,N-Diethyl-4-[[2-(4-methyl-1-oxophthalazin-2-yl)acetyl]amino]benzamide chemical structure, C22H24N4O3, CAS 684234-88-6
N,N-Diethyl-4-[[2-(4-methyl-1-oxophthalazin-2-yl)acetyl]amino]benzamide
CAS 684234-88-6C22H24N4O3
3-[2-(N-Methylanilino)-2-oxoethyl]-4-oxophthalazine-1-carboxylic acid chemical structure, C18H15N3O4, CAS 721914-25-6
3-[2-(N-Methylanilino)-2-oxoethyl]-4-oxophthalazine-1-carboxylic acid
CAS 721914-25-6C18H15N3O4
3-[2-(2-Methylanilino)-2-oxoethyl]-4-oxophthalazine-1-carboxylic acid chemical structure, C18H15N3O4, CAS 728893-17-2
3-[2-(2-Methylanilino)-2-oxoethyl]-4-oxophthalazine-1-carboxylic acid
CAS 728893-17-2C18H15N3O4
3-[2-[(2-Ethyl-6-methylphenyl)amino]-2-oxoethyl]-3,4-dihydro-4-oxo-1-phthalazinecarboxylic acid chemical structure, C20H19N3O4, CAS 851215-93-5
3-[2-[(2-Ethyl-6-methylphenyl)amino]-2-oxoethyl]-3,4-dihydro-4-oxo-1-phthalazinecarboxylic acid
CAS 851215-93-5C20H19N3O4
N-(3-Bromophenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide chemical structure, C16H12BrN3O2, CAS 1004510-01-3
N-(3-Bromophenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide
CAS 1004510-01-3C16H12BrN3O2
N-(2,4-Dimethoxyphenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide chemical structure, C18H17N3O4, CAS 1004247-75-9
N-(2,4-Dimethoxyphenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide
CAS 1004247-75-9C18H17N3O4
N-(3-Chlorophenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide chemical structure, C16H12ClN3O2, CAS 1282096-16-5
N-(3-Chlorophenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide
CAS 1282096-16-5C16H12ClN3O2
N-(4-Isopropylphenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide chemical structure, C19H19N3O2, CAS 1269364-32-0
N-(4-Isopropylphenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide
CAS 1269364-32-0C19H19N3O2
N-(3,4-Dimethoxyphenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide chemical structure, C18H17N3O4, CAS 1050860-25-7
N-(3,4-Dimethoxyphenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide
CAS 1050860-25-7C18H17N3O4
N-[3-(Acetylamino)phenyl]-2-(1-oxophthalazin-2(1H)-yl)acetamide chemical structure, C18H16N4O3, CAS 1062393-28-5
N-[3-(Acetylamino)phenyl]-2-(1-oxophthalazin-2(1H)-yl)acetamide
CAS 1062393-28-5C18H16N4O3
4-[[2-(1-Oxophthalazin-2-yl)acetyl]amino]benzamide chemical structure, C17H14N4O3, CAS 1050860-20-2
4-[[2-(1-Oxophthalazin-2-yl)acetyl]amino]benzamide
CAS 1050860-20-2C17H14N4O3
N-(2-Bromophenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide chemical structure, C16H12BrN3O2, CAS 1269009-86-0
N-(2-Bromophenyl)-2-(1-oxophthalazin-2(1H)-yl)acetamide
CAS 1269009-86-0C16H12BrN3O2