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Murcko scaffold

Ring system with 3 rings and 20 atoms

30 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
30
With full pages
17
Scaffold SMILES

O=C(CN1CCc2ccccc2C1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1CCc2ccccc2C1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

N-(2,4-Difluorophenyl)-2-(3,4-dihydro-2(1H)-isoquinolinyl)acetamide chemical structure, C17H16F2N2O, CAS 714210-81-8
N-(2,4-Difluorophenyl)-2-(3,4-dihydro-2(1H)-isoquinolinyl)acetamide
CAS 714210-81-8C17H16F2N2O
2-(3,4-Dihydroisoquinolin-2(1H)-yl)-N-[4-(trifluoromethyl)phenyl]acetamide chemical structure, C18H17F3N2O, CAS 838093-19-9
2-(3,4-Dihydroisoquinolin-2(1H)-yl)-N-[4-(trifluoromethyl)phenyl]acetamide
CAS 838093-19-9C18H17F3N2O
2(1H)-Isoquinolineacetamide, N-(4-chlorophenyl)-3,4-dihydro- chemical structure, C17H17ClN2O, CAS 89474-23-7
2(1H)-Isoquinolineacetamide, N-(4-chlorophenyl)-3,4-dihydro-
CAS 89474-23-7C17H17ClN2O
N-(4-Bromophenyl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamide chemical structure, C17H17BrN2O, CAS 89474-22-6
N-(4-Bromophenyl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamide
CAS 89474-22-6C17H17BrN2O
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,5-dimethoxyphenyl)acetamide chemical structure, C19H22N2O3, CAS 851614-49-8
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,5-dimethoxyphenyl)acetamide
CAS 851614-49-8C19H22N2O3
2(1H)-Isoquinolineacetamide, 3,4-dihydro-N-(4-methylphenyl)- chemical structure, C18H20N2O, CAS 89474-24-8
2(1H)-Isoquinolineacetamide, 3,4-dihydro-N-(4-methylphenyl)-
CAS 89474-24-8C18H20N2O
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-fluoro-4-methylphenyl)acetamide chemical structure, C18H19FN2O, CAS 851721-52-3
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-fluoro-4-methylphenyl)acetamide
CAS 851721-52-3C18H19FN2O
N-(2-Cyanophenyl)-2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)acetamide chemical structure, C20H21N3O3, CAS 790265-55-3
N-(2-Cyanophenyl)-2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)acetamide
CAS 790265-55-3C20H21N3O3
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-ethoxyphenyl)acetamide chemical structure, C19H22N2O2, CAS 852406-64-5
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-ethoxyphenyl)acetamide
CAS 852406-64-5C19H22N2O2
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(4-fluorophenyl)acetamide chemical structure, C17H17FN2O, CAS 838901-25-0
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(4-fluorophenyl)acetamide
CAS 838901-25-0C17H17FN2O
2-(3,4-Dihydro-2(1H)-isoquinolinyl)-N-(2,4-dimethoxyphenyl)acetamide chemical structure, C19H22N2O3, CAS 852824-06-7
2-(3,4-Dihydro-2(1H)-isoquinolinyl)-N-(2,4-dimethoxyphenyl)acetamide
CAS 852824-06-7C19H22N2O3
N-(2-Chlorophenyl)-2-(3,4-dihydro-1H-isoquinolin-2-yl)acetamide chemical structure, C17H17ClN2O, CAS 848594-00-3
N-(2-Chlorophenyl)-2-(3,4-dihydro-1H-isoquinolin-2-yl)acetamide
CAS 848594-00-3C17H17ClN2O
N-(3-Chloro-4-fluorophenyl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamide chemical structure, C17H16ClFN2O, CAS 850539-86-5
N-(3-Chloro-4-fluorophenyl)-2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamide
CAS 850539-86-5C17H16ClFN2O
2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(3-nitrophenyl)acetamide chemical structure, C19H21N3O5, CAS 879465-72-2
2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(3-nitrophenyl)acetamide
CAS 879465-72-2C19H21N3O5
2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(4-fluorophenyl)acetamide chemical structure, C19H21FN2O3, CAS 900272-03-9
2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-(4-fluorophenyl)acetamide
CAS 900272-03-9C19H21FN2O3
N-(2,4-Difluorophenyl)-2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)acetamide chemical structure, C19H20F2N2O3, CAS 900894-46-4
N-(2,4-Difluorophenyl)-2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)acetamide
CAS 900894-46-4C19H20F2N2O3
2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(2-methoxy-4-nitrophenyl)acetamide chemical structure, C20H23N3O6, CAS 883962-37-6
2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(2-methoxy-4-nitrophenyl)acetamide
CAS 883962-37-6C20H23N3O6
N-(2,6-Diethylphenyl)-2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)acetamide chemical structure, C23H30N2O3, CAS 902305-18-4
N-(2,6-Diethylphenyl)-2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)acetamide
CAS 902305-18-4C23H30N2O3
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(4-methylphenyl)propanamide chemical structure, C19H22N2O, CAS 89474-44-2
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(4-methylphenyl)propanamide
CAS 89474-44-2C19H22N2O
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-methoxyphenyl)acetamide chemical structure, C18H20N2O2, CAS 902735-44-8
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(3-methoxyphenyl)acetamide
CAS 902735-44-8C18H20N2O2
2-(3,4-Dihydroisoquinolin-2(1H)-yl)-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C19H22N2O2, CAS 869469-04-5
2-(3,4-Dihydroisoquinolin-2(1H)-yl)-N-(2-methoxy-5-methylphenyl)acetamide
CAS 869469-04-5C19H22N2O2
N-(5-Chloro-2-methylphenyl)-2-(3,4-dihydro-1H-isoquinolin-2-yl)acetamide chemical structure, C18H19ClN2O, CAS 902735-75-5
N-(5-Chloro-2-methylphenyl)-2-(3,4-dihydro-1H-isoquinolin-2-yl)acetamide
CAS 902735-75-5C18H19ClN2O
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-ethylphenyl)acetamide chemical structure, C19H22N2O, CAS 885441-94-1
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2-ethylphenyl)acetamide
CAS 885441-94-1C19H22N2O
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,3-dimethylphenyl)acetamide chemical structure, C19H22N2O, CAS 885442-20-6
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-N-(2,3-dimethylphenyl)acetamide
CAS 885442-20-6C19H22N2O