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Murcko scaffold

Ring system with 3 rings and 20 atoms

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
26
With full pages
16
Scaffold SMILES

O=C(COc1ccccc1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

2-(4-Bromophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C17H16BrNO2, CAS 351418-96-7
2-(4-Bromophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 351418-96-7C17H16BrNO2
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(2-nitrophenoxy)ethanone chemical structure, C17H16N2O4, CAS 375352-81-1
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(2-nitrophenoxy)ethanone
CAS 375352-81-1C17H16N2O4
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(2-fluorophenoxy)ethanone chemical structure, C17H16FNO2, CAS 438471-52-4
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(2-fluorophenoxy)ethanone
CAS 438471-52-4C17H16FNO2
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(4-propan-2-ylphenoxy)ethanone chemical structure, C20H23NO2, CAS 433235-13-3
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(4-propan-2-ylphenoxy)ethanone
CAS 433235-13-3C20H23NO2
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-o-tolyloxy-ethanone chemical structure, C18H19NO2, CAS 424808-36-6
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-o-tolyloxy-ethanone
CAS 424808-36-6C18H19NO2
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(3-methylphenoxy)ethanone chemical structure, C18H19NO2, CAS 755000-30-7
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(3-methylphenoxy)ethanone
CAS 755000-30-7C18H19NO2
2-(4-Chloro-3,5-dimethylphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C19H20ClNO2, CAS 733799-15-0
2-(4-Chloro-3,5-dimethylphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 733799-15-0C19H20ClNO2
2-(2-Chlorophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C17H16ClNO2, CAS 429627-59-8
2-(2-Chlorophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 429627-59-8C17H16ClNO2
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(2,4-dimethylphenoxy)ethanone chemical structure, C19H21NO2, CAS 695170-26-4
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(2,4-dimethylphenoxy)ethanone
CAS 695170-26-4C19H21NO2
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(3,4-dimethylphenoxy)ethanone chemical structure, C19H21NO2, CAS 431986-32-2
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(3,4-dimethylphenoxy)ethanone
CAS 431986-32-2C19H21NO2
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(4-methoxy-phenoxy)-ethanone chemical structure, C18H19NO3, CAS 367933-93-5
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(4-methoxy-phenoxy)-ethanone
CAS 367933-93-5C18H19NO3
2-(4-Bromo-3,5-dimethylphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C19H20BrNO2, CAS 435283-36-6
2-(4-Bromo-3,5-dimethylphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 435283-36-6C19H20BrNO2
2-(2-Bromo-4-ethylphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C19H20BrNO2, CAS 693805-45-7
2-(2-Bromo-4-ethylphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 693805-45-7C19H20BrNO2
2-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]benzonitrile chemical structure, C20H20N2O4, CAS 791092-68-7
2-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]benzonitrile
CAS 791092-68-7C20H20N2O4
2-(4-Bromo-2-chlorophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C17H15BrClNO2, CAS 430455-08-6
2-(4-Bromo-2-chlorophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 430455-08-6C17H15BrClNO2
2-(2-Bromo-4-chlorophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C17H15BrClNO2, CAS 496959-40-1
2-(2-Bromo-4-chlorophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 496959-40-1C17H15BrClNO2
2-(2-Bromo-4-tert-butylphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C21H24BrNO2, CAS 701221-64-9
2-(2-Bromo-4-tert-butylphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 701221-64-9C21H24BrNO2
2-[2-Oxo-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethoxy]benzamide chemical structure, C18H18N2O3, CAS 851723-62-1
2-[2-Oxo-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethoxy]benzamide
CAS 851723-62-1C18H18N2O3
2-(4-Acetyl-2-methoxyphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone chemical structure, C20H21NO4, CAS 851630-98-3
2-(4-Acetyl-2-methoxyphenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)ethanone
CAS 851630-98-3C20H21NO4
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(4-methoxyphenoxy)propan-1-one chemical structure, C19H21NO3, CAS 701246-19-7
1-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-(4-methoxyphenoxy)propan-1-one
CAS 701246-19-7C19H21NO3
2-(4-Bromophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)propan-1-one chemical structure, C18H18BrNO2, CAS 701251-47-0
2-(4-Bromophenoxy)-1-(3,4-dihydro-1H-isoquinolin-2-yl)propan-1-one
CAS 701251-47-0C18H18BrNO2
2-[2-(3,5-Dimethylphenoxy)acetyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid chemical structure, C20H21NO4, CAS 1008369-07-0
2-[2-(3,5-Dimethylphenoxy)acetyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS 1008369-07-0C20H21NO4
2-[2-(4-Chlorophenoxy)acetyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid chemical structure, C18H16ClNO4, CAS 1007926-86-4
2-[2-(4-Chlorophenoxy)acetyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS 1007926-86-4C18H16ClNO4
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-fluorophenoxy)propan-1-one chemical structure, C18H18FNO2, CAS 931856-16-5
1-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(4-fluorophenoxy)propan-1-one
CAS 931856-16-5C18H18FNO2