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Murcko scaffold

Ring system with 5 rings and 25 atoms

100 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
25
Chemicals
100
With full pages
9
Scaffold SMILES

O=C1Nc2ccccc2C1=c1sc2nc(-c3ccccc3)nn2c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C1=c1sc2nc(-c3ccccc3)nn2c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 100 chemicals

{(3Z)-3-[2-(3-Chlorophenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetic acid chemical structure, C20H11ClN4O4S, CAS 618854-35-6
{(3Z)-3-[2-(3-Chlorophenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetic acid
CAS 618854-35-6C20H11ClN4O4S
2-[(5Z)-5-(1-Ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate chemical structure, C22H16N4O4S, CAS 385419-26-1
2-[(5Z)-5-(1-Ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate
CAS 385419-26-1C22H16N4O4S
(3Z)-3-[2-(4-Butoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C23H20N4O3S, CAS 370587-38-5
(3Z)-3-[2-(4-Butoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-methyl-1,3-dihydro-2H-indol-2-one
CAS 370587-38-5C23H20N4O3S
2-[(5Z)-6-Oxo-5-(2-oxo-1-propyl-1,2-dihydro-3H-indol-3-ylidene)-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate chemical structure, C23H18N4O4S, CAS 385393-94-2
2-[(5Z)-6-Oxo-5-(2-oxo-1-propyl-1,2-dihydro-3H-indol-3-ylidene)-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate
CAS 385393-94-2C23H18N4O4S
2-[(5Z)-5-(1-Methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate chemical structure, C21H14N4O4S, CAS 329923-20-8
2-[(5Z)-5-(1-Methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate
CAS 329923-20-8C21H14N4O4S
(3Z)-3-[2-(4-Butoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C25H24N4O3S, CAS 371923-20-5
(3Z)-3-[2-(4-Butoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-propyl-1,3-dihydro-2H-indol-2-one
CAS 371923-20-5C25H24N4O3S
(3Z)-3-[2-(4-Butoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-butyl-1,3-dihydro-2H-indol-2-one chemical structure, C26H26N4O3S, CAS 371235-35-7
(3Z)-3-[2-(4-Butoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-butyl-1,3-dihydro-2H-indol-2-one
CAS 371235-35-7C26H26N4O3S
[2-[(5Z)-6-Oxo-5-(2-oxo-1-prop-2-enylindol-3-ylidene)-[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl] acetate chemical structure, C23H16N4O4S, CAS 432000-41-4
[2-[(5Z)-6-Oxo-5-(2-oxo-1-prop-2-enylindol-3-ylidene)-[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl] acetate
CAS 432000-41-4C23H16N4O4S
2-[(5Z)-5-(1-Heptyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate chemical structure, C27H26N4O4S, CAS 384374-73-6
2-[(5Z)-5-(1-Heptyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-6-oxo-5,6-dihydro[1,3]thiazolo[3,2-b][1,2,4]triazol-2-yl]phenyl acetate
CAS 384374-73-6C27H26N4O4S
{(3Z)-2-Oxo-3-[6-oxo-2-(4-propoxyphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2,3-dihydro-1H-indol-1-yl}acetic acid chemical structure, C23H18N4O5S, CAS 606963-03-5
{(3Z)-2-Oxo-3-[6-oxo-2-(4-propoxyphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2,3-dihydro-1H-indol-1-yl}acetic acid
CAS 606963-03-5C23H18N4O5S
(5Z)-2-(2-Bromophenyl)-5-(1-ethyl-2-oxoindol-3-ylidene)-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one chemical structure, C20H13BrN4O2S, CAS 618854-31-2
(5Z)-2-(2-Bromophenyl)-5-(1-ethyl-2-oxoindol-3-ylidene)-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one
CAS 618854-31-2C20H13BrN4O2S
(5Z)-2-(2-Bromophenyl)-5-(2-oxo-1-propylindol-3-ylidene)-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one chemical structure, C21H15BrN4O2S, CAS 578759-94-1
(5Z)-2-(2-Bromophenyl)-5-(2-oxo-1-propylindol-3-ylidene)-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one
CAS 578759-94-1C21H15BrN4O2S
(3Z)-5-Bromo-3-[2-(4-fluorophenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C21H12BrFN4O2S, CAS 618854-73-2
(3Z)-5-Bromo-3-[2-(4-fluorophenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one
CAS 618854-73-2C21H12BrFN4O2S
(3Z)-1-Butyl-3-[2-(3,4-dimethoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C24H22N4O4S, CAS 573931-33-6
(3Z)-1-Butyl-3-[2-(3,4-dimethoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 573931-33-6C24H22N4O4S
(3Z)-1-Butyl-3-[2-(3-chlorophenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C22H17ClN4O2S, CAS 573932-41-9
(3Z)-1-Butyl-3-[2-(3-chlorophenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 573932-41-9C22H17ClN4O2S
(3Z)-5-Bromo-1-butyl-3-[2-(3-chlorophenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C22H16BrClN4O2S, CAS 573938-93-9
(3Z)-5-Bromo-1-butyl-3-[2-(3-chlorophenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 573938-93-9C22H16BrClN4O2S
(3Z)-3-[2-(3-Methylphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C22H18N4O2S, CAS 573941-99-8
(3Z)-3-[2-(3-Methylphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-propyl-1,3-dihydro-2H-indol-2-one
CAS 573941-99-8C22H18N4O2S
(3Z)-3-[2-(3,4-Dimethoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-heptyl-1,3-dihydro-2H-indol-2-one chemical structure, C27H28N4O4S, CAS 573944-56-6
(3Z)-3-[2-(3,4-Dimethoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-heptyl-1,3-dihydro-2H-indol-2-one
CAS 573944-56-6C27H28N4O4S
{(3Z)-3-[2-(3-Methylphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetic acid chemical structure, C21H14N4O4S, CAS 573945-07-0
{(3Z)-3-[2-(3-Methylphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetic acid
CAS 573945-07-0C21H14N4O4S
(3Z)-5-Bromo-3-[2-(2-methylphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C22H17BrN4O2S, CAS 573946-85-7
(3Z)-5-Bromo-3-[2-(2-methylphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1-propyl-1,3-dihydro-2H-indol-2-one
CAS 573946-85-7C22H17BrN4O2S
2-{(3Z)-3-[2-(4-Butoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetamide chemical structure, C24H21N5O4S, CAS 606963-58-0
2-{(3Z)-3-[2-(4-Butoxyphenyl)-6-oxo[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetamide
CAS 606963-58-0C24H21N5O4S
2-{(3Z)-2-Oxo-3-[6-oxo-2-(4-propoxyphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2,3-dihydro-1H-indol-1-yl}acetamide chemical structure, C23H19N5O4S, CAS 606963-05-7
2-{(3Z)-2-Oxo-3-[6-oxo-2-(4-propoxyphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-2,3-dihydro-1H-indol-1-yl}acetamide
CAS 606963-05-7C23H19N5O4S
2-(3-(2-(4-Butoxyphenyl)-6-oxothiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene)-2-oxoindolin-1-yl)acetic acid chemical structure, C24H20N4O5S, CAS 606963-57-9
2-(3-(2-(4-Butoxyphenyl)-6-oxothiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene)-2-oxoindolin-1-yl)acetic acid
CAS 606963-57-9C24H20N4O5S
(3Z)-1-Heptyl-3-[6-oxo-2-(4-propoxyphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C28H30N4O3S, CAS 606963-11-5
(3Z)-1-Heptyl-3-[6-oxo-2-(4-propoxyphenyl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 606963-11-5C28H30N4O3S