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Murcko scaffold

Ring system with 2 rings and 19 atoms

32 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
19
Chemicals
32
With full pages
7
Scaffold SMILES

O=C(CNS(=O)(=O)c1ccccc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNS(=O)(=O)c1ccccc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

N,4-dimethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C15H23N3O3S, CAS 501914-72-3
N,4-dimethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 501914-72-3C15H23N3O3S
4-Fluoro-N-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C14H20FN3O3S, CAS 675861-67-3
4-Fluoro-N-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 675861-67-3C14H20FN3O3S
Ethyl 4-{N-methyl-N-[(4-methylphenyl)sulfonyl]glycyl}piperazine-1-carboxylate chemical structure, C17H25N3O5S, CAS 505052-06-2
Ethyl 4-{N-methyl-N-[(4-methylphenyl)sulfonyl]glycyl}piperazine-1-carboxylate
CAS 505052-06-2C17H25N3O5S
Ethyl 4-({[(4-bromophenyl)sulfonyl]amino}acetyl)-1-piperazinecarboxylate chemical structure, C15H20BrN3O5S, CAS 639791-15-4
Ethyl 4-({[(4-bromophenyl)sulfonyl]amino}acetyl)-1-piperazinecarboxylate
CAS 639791-15-4C15H20BrN3O5S
Ethyl 4-{N-[(3-chloro-4-methoxyphenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate chemical structure, C17H24ClN3O6S, CAS 714213-43-1
Ethyl 4-{N-[(3-chloro-4-methoxyphenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate
CAS 714213-43-1C17H24ClN3O6S
Ethyl 4-{N-[(2,5-dimethoxyphenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate chemical structure, C18H27N3O7S, CAS 791805-27-1
Ethyl 4-{N-[(2,5-dimethoxyphenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate
CAS 791805-27-1C18H27N3O7S
Ethyl 4-{N-[(4-chlorophenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate chemical structure, C16H22ClN3O5S, CAS 510716-65-1
Ethyl 4-{N-[(4-chlorophenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate
CAS 510716-65-1C16H22ClN3O5S
Ethyl 4-{N-[(4-bromophenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate chemical structure, C16H22BrN3O5S, CAS 510716-71-9
Ethyl 4-{N-[(4-bromophenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate
CAS 510716-71-9C16H22BrN3O5S
Ethyl 4-{N-[(4-fluorophenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate chemical structure, C16H22FN3O5S, CAS 675861-77-5
Ethyl 4-{N-[(4-fluorophenyl)sulfonyl]-N-methylglycyl}piperazine-1-carboxylate
CAS 675861-77-5C16H22FN3O5S
Ethyl 4-{N-methyl-N-[(2,4,6-trimethylphenyl)sulfonyl]glycyl}piperazine-1-carboxylate chemical structure, C19H29N3O5S, CAS 675862-35-8
Ethyl 4-{N-methyl-N-[(2,4,6-trimethylphenyl)sulfonyl]glycyl}piperazine-1-carboxylate
CAS 675862-35-8C19H29N3O5S
N,2,4,6-tetramethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C17H27N3O3S, CAS 675862-30-3
N,2,4,6-tetramethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 675862-30-3C17H27N3O3S
3-Chloro-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-4-methoxy-N-methylbenzenesulfonamide chemical structure, C16H24ClN3O4S, CAS 718603-52-2
3-Chloro-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-4-methoxy-N-methylbenzenesulfonamide
CAS 718603-52-2C16H24ClN3O4S
4-Methoxy-N,3-dimethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C16H25N3O4S, CAS 718604-24-1
4-Methoxy-N,3-dimethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 718604-24-1C16H25N3O4S
4-Chloro-N-ethyl-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C16H24ClN3O3S, CAS 831236-49-8
4-Chloro-N-ethyl-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 831236-49-8C16H24ClN3O3S
3-Chloro-4-methoxy-N-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C15H22ClN3O4S, CAS 712319-82-9
3-Chloro-4-methoxy-N-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 712319-82-9C15H22ClN3O4S
Ethyl 4-{N-[(4-chlorophenyl)sulfonyl]-N-ethylglycyl}piperazine-1-carboxylate chemical structure, C17H24ClN3O5S, CAS 825657-37-2
Ethyl 4-{N-[(4-chlorophenyl)sulfonyl]-N-ethylglycyl}piperazine-1-carboxylate
CAS 825657-37-2C17H24ClN3O5S
N-Ethyl-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-4-fluorobenzenesulfonamide chemical structure, C16H24FN3O3S, CAS 838876-62-3
N-Ethyl-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-4-fluorobenzenesulfonamide
CAS 838876-62-3C16H24FN3O3S
2,5-Dichloro-N-ethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C15H21Cl2N3O3S, CAS 838881-73-5
2,5-Dichloro-N-ethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 838881-73-5C15H21Cl2N3O3S
N-Ethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C15H23N3O3S, CAS 838885-92-0
N-Ethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 838885-92-0C15H23N3O3S
Ethyl 4-{N-[(2,5-dichlorophenyl)sulfonyl]-N-ethylglycyl}piperazine-1-carboxylate chemical structure, C17H23Cl2N3O5S, CAS 838905-90-1
Ethyl 4-{N-[(2,5-dichlorophenyl)sulfonyl]-N-ethylglycyl}piperazine-1-carboxylate
CAS 838905-90-1C17H23Cl2N3O5S
N-Ethyl-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C16H25N3O3S, CAS 915881-28-6
N-Ethyl-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 915881-28-6C16H25N3O3S
3-Chloro-4-methoxy-N-[1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]benzenesulfonamide chemical structure, C15H22ClN3O4S, CAS 1040557-20-7
3-Chloro-4-methoxy-N-[1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]benzenesulfonamide
CAS 1040557-20-7C15H22ClN3O4S
4-Ethoxy-N,3-dimethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C17H27N3O4S, CAS 936821-37-3
4-Ethoxy-N,3-dimethyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 936821-37-3C17H27N3O4S
4-Ethoxy-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-N,3-dimethylbenzenesulfonamide chemical structure, C18H29N3O4S, CAS 936821-38-4
4-Ethoxy-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-N,3-dimethylbenzenesulfonamide
CAS 936821-38-4C18H29N3O4S