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Murcko scaffold

2-Morpholinopyrazine scaffold

73 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
73
With full pages
5
Scaffold SMILES

c1cnc(N2CCOCC2)cn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Morpholinopyrazine page
Murcko scaffold c1cnc(N2CCOCC2)cn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 73 of 73 chemicals

6-(4-Morpholinyl)-2-pyrazinecarboxamide chemical structure, C9H12N4O2, CAS 40262-75-7
6-(4-Morpholinyl)-2-pyrazinecarboxamide
CAS 40262-75-7C9H12N4O2
1-[5-(4-Morpholinyl)-2-pyrazinyl]ethanone chemical structure, C10H13N3O2, CAS 265107-92-4
1-[5-(4-Morpholinyl)-2-pyrazinyl]ethanone
CAS 265107-92-4C10H13N3O2
tert-Butyl (5-morpholinopyrazin-2-yl)carbamate chemical structure, C13H20N4O3, CAS 2007919-55-1
tert-Butyl (5-morpholinopyrazin-2-yl)carbamate
CAS 2007919-55-1C13H20N4O3
2-Bromo-5-(morpholino-d8)-pyrazine chemical structure, C8H10BrN3O, CAS 1643542-92-0
2-Bromo-5-(morpholino-d8)-pyrazine
CAS 1643542-92-0C8H10BrN3O
2-Amino-5-(morpholino-d8)-pyrazine chemical structure, C8H12N4O, CAS 1643539-19-8
2-Amino-5-(morpholino-d8)-pyrazine
CAS 1643539-19-8C8H12N4O
2-Bromo-6-(morpholino-d8)-pyrazine chemical structure, C8H10BrN3O, CAS 1643543-50-3
2-Bromo-6-(morpholino-d8)-pyrazine
CAS 1643543-50-3C8H10BrN3O
2-Amino-6-(morpholino-d8)-pyrazine chemical structure, C8H12N4O, CAS 1643563-32-9
2-Amino-6-(morpholino-d8)-pyrazine
CAS 1643563-32-9C8H12N4O
2-Bromo-5-(morpholino)pyrazine-d10 chemical structure, C8H10BrN3O, CAS 1643575-70-5
2-Bromo-5-(morpholino)pyrazine-d10
CAS 1643575-70-5C8H10BrN3O
2-Bromo-6-(morpholino)pyrazine-d10 chemical structure, C8H10BrN3O, CAS 1643543-56-9
2-Bromo-6-(morpholino)pyrazine-d10
CAS 1643543-56-9C8H10BrN3O
5-[2-({[(tert-Butoxy)carbonyl]amino}methyl)morpholin-4-yl]pyrazine-2-carboxylic acid chemical structure, C15H22N4O5, CAS 2260937-63-9
5-[2-({[(tert-Butoxy)carbonyl]amino}methyl)morpholin-4-yl]pyrazine-2-carboxylic acid
CAS 2260937-63-9C15H22N4O5
1-{[5-Bromo-3-(morpholin-4-yl)pyrazin-2-yl]oxy}-3-(tert-butylamino)propan-2-ol chemical structure, C15H25BrN4O3, CAS 54126-51-1
1-{[5-Bromo-3-(morpholin-4-yl)pyrazin-2-yl]oxy}-3-(tert-butylamino)propan-2-ol
CAS 54126-51-1C15H25BrN4O3
3-Chloro-5-(4-morpholinyl)-2-pyrazinecarbonitrile chemical structure, C9H9ClN4O, CAS 1430460-83-5
3-Chloro-5-(4-morpholinyl)-2-pyrazinecarbonitrile
CAS 1430460-83-5C9H9ClN4O
4-(6-Chloro-3-iodo-2-pyrazinyl)morpholine chemical structure, C8H9ClIN3O, CAS 1430460-70-0
4-(6-Chloro-3-iodo-2-pyrazinyl)morpholine
CAS 1430460-70-0C8H9ClIN3O
Ethyl 5-[2-(aminomethyl)morpholin-4-yl]pyrazine-2-carboxylate chemical structure, C12H18N4O3, CAS 2639431-96-0
Ethyl 5-[2-(aminomethyl)morpholin-4-yl]pyrazine-2-carboxylate
CAS 2639431-96-0C12H18N4O3
Methyl 5-[2-(aminomethyl)morpholin-4-yl]pyrazine-2-carboxylate chemical structure, C11H16N4O3, CAS 2639439-17-9
Methyl 5-[2-(aminomethyl)morpholin-4-yl]pyrazine-2-carboxylate
CAS 2639439-17-9C11H16N4O3
5-[2-(Aminomethyl)morpholin-4-yl]pyrazine-2-carboxylic acid chemical structure, C10H14N4O3, CAS 2639419-80-8
5-[2-(Aminomethyl)morpholin-4-yl]pyrazine-2-carboxylic acid
CAS 2639419-80-8C10H14N4O3
tert-Butyl 5-[2-(aminomethyl)morpholin-4-yl]pyrazine-2-carboxylate chemical structure, C14H22N4O3, CAS 2639453-05-5
tert-Butyl 5-[2-(aminomethyl)morpholin-4-yl]pyrazine-2-carboxylate
CAS 2639453-05-5C14H22N4O3
5-{2-[(2,2,2-Trifluoroacetamido)methyl]morpholin-4-yl}pyrazine-2-carboxylic acid chemical structure, C12H13F3N4O4, CAS 2680887-09-4
5-{2-[(2,2,2-Trifluoroacetamido)methyl]morpholin-4-yl}pyrazine-2-carboxylic acid
CAS 2680887-09-4C12H13F3N4O4
5-[2-(Acetamidomethyl)morpholin-4-yl]pyrazine-2-carboxylic acid chemical structure, C12H16N4O4, CAS 2680841-79-4
5-[2-(Acetamidomethyl)morpholin-4-yl]pyrazine-2-carboxylic acid
CAS 2680841-79-4C12H16N4O4
5-[2-({[(Prop-2-en-1-yloxy)carbonyl]amino}methyl)morpholin-4-yl]pyrazine-2-carboxylic acid chemical structure, C14H18N4O5, CAS 2870653-53-3
5-[2-({[(Prop-2-en-1-yloxy)carbonyl]amino}methyl)morpholin-4-yl]pyrazine-2-carboxylic acid
CAS 2870653-53-3C14H18N4O5
4-(3,6-Dimethylpyrazin-2-yl)-N-methylmorpholine-2-carboxamide chemical structure, C12H18N4O2, CAS 2877703-04-1
4-(3,6-Dimethylpyrazin-2-yl)-N-methylmorpholine-2-carboxamide
CAS 2877703-04-1C12H18N4O2
N-Methyl-4-(6-methylpyrazin-2-yl)morpholine-2-carboxamide chemical structure, C11H16N4O2, CAS 2877701-86-3
N-Methyl-4-(6-methylpyrazin-2-yl)morpholine-2-carboxamide
CAS 2877701-86-3C11H16N4O2
4-(5-Bromo-3-methylpyrazin-2-yl)morpholine chemical structure, C9H12BrN3O, CAS 3078337-90-0
4-(5-Bromo-3-methylpyrazin-2-yl)morpholine
CAS 3078337-90-0C9H12BrN3O
6-(Morpholino-d8)pyrazin-3,5-d2-2-amine chemical structure, C8H12N4O, CAS 2363782-10-7
6-(Morpholino-d8)pyrazin-3,5-d2-2-amine
CAS 2363782-10-7C8H12N4O