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Murcko scaffold

Ring system with 3 rings and 27 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
27
Chemicals
9
With full pages
4
Scaffold SMILES

O=C(NCc1ccncc1)C(=Cc1ccccc1)NC(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1ccncc1)C(=Cc1ccccc1)NC(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

N-[(Z)-1-(4-Methoxyphenyl)-3-oxo-3-(pyridin-4-ylmethylamino)prop-1-en-2-yl]benzamide chemical structure, C23H21N3O3, CAS 406711-43-1
N-[(Z)-1-(4-Methoxyphenyl)-3-oxo-3-(pyridin-4-ylmethylamino)prop-1-en-2-yl]benzamide
CAS 406711-43-1C23H21N3O3
N-{2-(4-Dimethylamino-phenyl)-1-[(pyridin-4-ylmethyl)-carbamoyl]-vinyl}-benzamide chemical structure, C24H24N4O2, CAS 372504-43-3
N-{2-(4-Dimethylamino-phenyl)-1-[(pyridin-4-ylmethyl)-carbamoyl]-vinyl}-benzamide
CAS 372504-43-3C24H24N4O2
(2Z)-3-(4-Chlorophenyl)-2-[(4-methoxyphenyl)formamido]-N-[(pyridin-4-yl)methyl]prop-2-enamide chemical structure, C23H20ClN3O3, CAS 406711-46-4
(2Z)-3-(4-Chlorophenyl)-2-[(4-methoxyphenyl)formamido]-N-[(pyridin-4-yl)methyl]prop-2-enamide
CAS 406711-46-4C23H20ClN3O3
N-((Z)-2-(4-Chlorophenyl)-1-{[(4-pyridinylmethyl)amino]carbonyl}ethenyl)-4-methylbenzamide chemical structure, C23H20ClN3O2, CAS 406710-85-8
N-((Z)-2-(4-Chlorophenyl)-1-{[(4-pyridinylmethyl)amino]carbonyl}ethenyl)-4-methylbenzamide
CAS 406710-85-8C23H20ClN3O2
N-{2-(4-Fluoro-phenyl)-1-[(pyridin-4-ylmethyl)-carbamoyl]-vinyl}-benzamide chemical structure, C22H18FN3O2, CAS 406710-82-5
N-{2-(4-Fluoro-phenyl)-1-[(pyridin-4-ylmethyl)-carbamoyl]-vinyl}-benzamide
CAS 406710-82-5C22H18FN3O2
RefChem:345373 chemical structure, C23H20ClN3O3, CAS 6241-15-2
RefChem:345373
CAS 6241-15-2C23H20ClN3O3
N-[(Z)-2-(4-Methoxyphenyl)-1-(pyridin-4-ylmethylcarbamoyl)ethenyl]benzamide chemical structure, C23H21N3O3, CAS 6238-11-5
N-[(Z)-2-(4-Methoxyphenyl)-1-(pyridin-4-ylmethylcarbamoyl)ethenyl]benzamide
CAS 6238-11-5C23H21N3O3
N-((Z)-2-(4-Methoxyphenyl)-1-{[(4-pyridinylmethyl)amino]carbonyl}ethenyl)-4-methylbenzamide chemical structure, C24H23N3O3, CAS 327979-65-7
N-((Z)-2-(4-Methoxyphenyl)-1-{[(4-pyridinylmethyl)amino]carbonyl}ethenyl)-4-methylbenzamide
CAS 327979-65-7C24H23N3O3
N(2-(4-Isopropyl-PH)-1-(((4-pyridinylmethyl)amino)carbonyl)vinyl)-4-ME-benzamide chemical structure, C26H27N3O2, CAS 624726-81-4
N(2-(4-Isopropyl-PH)-1-(((4-pyridinylmethyl)amino)carbonyl)vinyl)-4-ME-benzamide
CAS 624726-81-4C26H27N3O2