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Murcko scaffold

Ring system with 3 rings and 22 atoms

21 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
21
With full pages
6
Scaffold SMILES

O=C(CCCOc1ccccc1)Nc1cc2c(s1)CCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCCOc1ccccc1)Nc1cc2c(s1)CCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

2-{[4-(4-Chlorophenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C19H21ClN2O3S, CAS 369397-12-6
2-{[4-(4-Chlorophenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 369397-12-6C19H21ClN2O3S
2-(4-Phenoxybutanoylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C19H22N2O3S, CAS 347914-06-1
2-(4-Phenoxybutanoylamino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 347914-06-1C19H22N2O3S
Methyl 2-[(4-phenoxybutanoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C20H23NO4S, CAS 303033-08-1
Methyl 2-[(4-phenoxybutanoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 303033-08-1C20H23NO4S
Ethyl 2-{[4-(2,4-dichlorophenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C21H23Cl2NO4S, CAS 299950-98-4
Ethyl 2-{[4-(2,4-dichlorophenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 299950-98-4C21H23Cl2NO4S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2,4-dichlorophenoxy)butanamide chemical structure, C19H18Cl2N2O2S, CAS 314055-58-8
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2,4-dichlorophenoxy)butanamide
CAS 314055-58-8C19H18Cl2N2O2S
2-[[4-(4-Chloro-3-methylphenoxy)-1-oxobutyl]amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C20H23ClN2O3S, CAS 808172-25-0
2-[[4-(4-Chloro-3-methylphenoxy)-1-oxobutyl]amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 808172-25-0C20H23ClN2O3S
Propan-2-yl 2-[4-(2,4-dichlorophenoxy)butanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C22H25Cl2NO4S, CAS 354541-97-2
Propan-2-yl 2-[4-(2,4-dichlorophenoxy)butanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 354541-97-2C22H25Cl2NO4S
2-{[4-(2,4-Dichlorophenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C19H20Cl2N2O3S, CAS 327070-88-2
2-{[4-(2,4-Dichlorophenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 327070-88-2C19H20Cl2N2O3S
2-{[4-(2,4-Dichlorophenoxy)butanoyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H22Cl2N2O3S, CAS 303033-25-2
2-{[4-(2,4-Dichlorophenoxy)butanoyl]amino}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 303033-25-2C20H22Cl2N2O3S
Methyl 6-methyl-2-[(4-phenoxybutanoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C21H25NO4S, CAS 459152-52-4
Methyl 6-methyl-2-[(4-phenoxybutanoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 459152-52-4C21H25NO4S
6-Methyl-2-(4-phenoxybutanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C20H24N2O3S, CAS 459152-53-5
6-Methyl-2-(4-phenoxybutanamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 459152-53-5C20H24N2O3S
N-(3-Cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2,4-dichlorophenoxy)butanamide chemical structure, C20H20Cl2N2O2S, CAS 329227-13-6
N-(3-Cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2,4-dichlorophenoxy)butanamide
CAS 329227-13-6C20H20Cl2N2O2S
Methyl 6-methyl-2-{[4-(2-methylphenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C22H27NO4S, CAS 433250-97-6
Methyl 6-methyl-2-{[4-(2-methylphenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 433250-97-6C22H27NO4S
6-Methyl-2-{[4-(2-methylphenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H26N2O3S, CAS 384794-09-6
6-Methyl-2-{[4-(2-methylphenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 384794-09-6C21H26N2O3S
N-(3-Cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2-methylphenoxy)butanamide chemical structure, C21H24N2O2S, CAS 459414-29-0
N-(3-Cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2-methylphenoxy)butanamide
CAS 459414-29-0C21H24N2O2S
6-Methyl-2-{[4-(4-methylphenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H26N2O3S, CAS 431992-60-8
6-Methyl-2-{[4-(4-methylphenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 431992-60-8C21H26N2O3S
2-(4-(4-(tert-Butyl)phenoxy)butanamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C24H32N2O3S, CAS 453585-72-3
2-(4-(4-(tert-Butyl)phenoxy)butanamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 453585-72-3C24H32N2O3S
6-Methyl-2-{[4-(3-methylphenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H26N2O3S, CAS 383898-60-0
6-Methyl-2-{[4-(3-methylphenoxy)butanoyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 383898-60-0C21H26N2O3S
N-(3-Cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2,4-dimethylphenoxy)butanamide chemical structure, C22H26N2O2S, CAS 496036-35-2
N-(3-Cyano-6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-4-(2,4-dimethylphenoxy)butanamide
CAS 496036-35-2C22H26N2O2S
2-{[4-(2,4-Dichlorophenoxy)butanoyl]amino}-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H24Cl2N2O3S, CAS 541536-13-4
2-{[4-(2,4-Dichlorophenoxy)butanoyl]amino}-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 541536-13-4C21H24Cl2N2O3S
2-(4-(2,4-Dimethylphenoxy)butanamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C22H28N2O3S, CAS 691387-77-6
2-(4-(2,4-Dimethylphenoxy)butanamido)-6-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide
CAS 691387-77-6C22H28N2O3S