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Murcko scaffold

Ring system with 3 rings and 22 atoms

19 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
19
With full pages
3
Scaffold SMILES

O=C(CSc1nc2ccccc2o1)NN=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nc2ccccc2o1)NN=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

4-[[[2-(1,3-Benzoxazol-3-ium-2-ylsulfanyl)acetyl]hydrazinylidene]methyl]benzoate chemical structure, C17H13N3O4S, CAS 5680-58-0
4-[[[2-(1,3-Benzoxazol-3-ium-2-ylsulfanyl)acetyl]hydrazinylidene]methyl]benzoate
CAS 5680-58-0C17H13N3O4S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-phenylethylidene]acetohydrazide chemical structure, C17H15N3O2S, CAS 133943-00-7
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-phenylethylidene]acetohydrazide
CAS 133943-00-7C17H15N3O2S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-(4-chlorophenyl)ethylidene]acetohydrazide chemical structure, C17H14ClN3O2S, CAS 155595-00-9
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-(4-chlorophenyl)ethylidene]acetohydrazide
CAS 155595-00-9C17H14ClN3O2S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-(4-bromophenyl)ethylidene]acetohydrazide chemical structure, C17H14BrN3O2S, CAS 343354-64-3
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-(4-bromophenyl)ethylidene]acetohydrazide
CAS 343354-64-3C17H14BrN3O2S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-(3,4-dimethoxyphenyl)ethylidene]acetohydrazide chemical structure, C19H19N3O4S, CAS 346437-87-4
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-(3,4-dimethoxyphenyl)ethylidene]acetohydrazide
CAS 346437-87-4C19H19N3O4S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-(4-methoxyphenyl)ethylidene]acetohydrazide chemical structure, C18H17N3O3S, CAS 155595-06-5
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1E)-1-(4-methoxyphenyl)ethylidene]acetohydrazide
CAS 155595-06-5C18H17N3O3S
(E)-2-(Benzo[d]oxazol-2-ylthio)-N'-(4-(dimethylamino)benzylidene)acetohydrazide chemical structure, C18H18N4O2S, CAS 113546-72-8
(E)-2-(Benzo[d]oxazol-2-ylthio)-N'-(4-(dimethylamino)benzylidene)acetohydrazide
CAS 113546-72-8C18H18N4O2S
4-[(E)-[[2-(1,3-Benzoxazol-2-ylsulfanyl)acetyl]hydrazinylidene]methyl]benzoic acid chemical structure, C17H13N3O4S, CAS 385405-44-7
4-[(E)-[[2-(1,3-Benzoxazol-2-ylsulfanyl)acetyl]hydrazinylidene]methyl]benzoic acid
CAS 385405-44-7C17H13N3O4S
(E)-2-(Benzo[d]oxazol-2-ylthio)-N'-(4-(diethylamino)benzylidene)acetohydrazide chemical structure, C20H22N4O2S, CAS 326887-02-9
(E)-2-(Benzo[d]oxazol-2-ylthio)-N'-(4-(diethylamino)benzylidene)acetohydrazide
CAS 326887-02-9C20H22N4O2S
2-[2-[(E)-[[2-(1,3-Benzoxazol-2-ylsulfanyl)acetyl]hydrazinylidene]methyl]phenoxy]acetic acid chemical structure, C18H15N3O5S, CAS 385405-41-4
2-[2-[(E)-[[2-(1,3-Benzoxazol-2-ylsulfanyl)acetyl]hydrazinylidene]methyl]phenoxy]acetic acid
CAS 385405-41-4C18H15N3O5S
2-[(E)-[[2-(1,3-Benzoxazol-2-ylsulfanyl)acetyl]hydrazinylidene]methyl]benzoic acid chemical structure, C17H13N3O4S, CAS 347350-02-1
2-[(E)-[[2-(1,3-Benzoxazol-2-ylsulfanyl)acetyl]hydrazinylidene]methyl]benzoic acid
CAS 347350-02-1C17H13N3O4S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1Z)-1-(3-methoxyphenyl)ethylidene]acetohydrazide chemical structure, C18H17N3O3S, CAS 474481-00-0
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1Z)-1-(3-methoxyphenyl)ethylidene]acetohydrazide
CAS 474481-00-0C18H17N3O3S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1Z)-1-(3,4-dichlorophenyl)ethylidene]acetohydrazide chemical structure, C17H13Cl2N3O2S, CAS 497077-75-5
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1Z)-1-(3,4-dichlorophenyl)ethylidene]acetohydrazide
CAS 497077-75-5C17H13Cl2N3O2S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1Z)-1-(3-bromophenyl)ethylidene]acetohydrazide chemical structure, C17H14BrN3O2S, CAS 499116-13-1
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1Z)-1-(3-bromophenyl)ethylidene]acetohydrazide
CAS 499116-13-1C17H14BrN3O2S
(E)-2-(Benzo[d]oxazol-2-ylthio)-N'-(4-(dimethylamino)-3-nitrobenzylidene)acetohydrazide chemical structure, C18H17N5O4S, CAS 326887-00-7
(E)-2-(Benzo[d]oxazol-2-ylthio)-N'-(4-(dimethylamino)-3-nitrobenzylidene)acetohydrazide
CAS 326887-00-7C18H17N5O4S
(Benzooxazol-2-ylsulfanyl)-acetic acid [1-(3-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazide chemical structure, C17H15N3O3S, CAS 500145-80-2
(Benzooxazol-2-ylsulfanyl)-acetic acid [1-(3-hydroxy-phenyl)-eth-(E)-ylidene]-hydrazide
CAS 500145-80-2C17H15N3O3S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[4-(diethylamino)-2-hydroxybenzylidene]acetohydrazide chemical structure, C20H22N4O3S, CAS 385405-30-1
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[4-(diethylamino)-2-hydroxybenzylidene]acetohydrazide
CAS 385405-30-1C20H22N4O3S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1Z)-1-(4-hydroxy-3-methoxyphenyl)ethylidene]acetohydrazide chemical structure, C18H17N3O4S, CAS 496775-20-3
2-(1,3-Benzoxazol-2-ylsulfanyl)-N'-[(1Z)-1-(4-hydroxy-3-methoxyphenyl)ethylidene]acetohydrazide
CAS 496775-20-3C18H17N3O4S
2-(1,3-Benzoxazol-2-ylsulfanyl)-N-[(E)-(3-bromo-4-hydroxy-5-methoxyphenyl)methylideneamino]acetamide chemical structure, C17H14BrN3O4S, CAS 345323-91-3
2-(1,3-Benzoxazol-2-ylsulfanyl)-N-[(E)-(3-bromo-4-hydroxy-5-methoxyphenyl)methylideneamino]acetamide
CAS 345323-91-3C17H14BrN3O4S