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Murcko scaffold

Ring system with 4 rings and 25 atoms

19 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 19
With full pages: 8

Scaffold SMILES

O=C(CCc1ccccc1)NC1COC(n2cnc3cncnc32)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CCc1ccccc1)NC1COC(n2cnc3cncnc32)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

2-Amino-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide chemical structure, C22H29N7O5, CAS 873075-72-0

2-Amino-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide

CAS 873075-72-0C₂₂H₂₉N₇O₅

Methionylpuromycin chemical structure, C27H38N8O6S, CAS 6042-08-6

Methionylpuromycin

CAS 6042-08-6C₂₇H₃₈N₈O₆S

Chryscandin chemical structure, C20H23N7O6, CAS 86936-90-5

CAS 86936-90-5C₂₀H₂₃N₇O₆

2-Amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-hydroxyphenyl)propanamide chemical structure, C21H27N7O5, CAS 21708-87-2

2-Amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-hydroxyphenyl)propanamide

CAS 21708-87-2C₂₁H₂₇N₇O₅

4-Azidopuromycin chemical structure, C21H26N10O4, CAS 67607-41-4

4-Azidopuromycin

CAS 67607-41-4C₂₁H₂₆N₁₀O₄

N-Iodoacetylpuromycin chemical structure, C24H30IN7O6, CAS 51959-56-9

N-Iodoacetylpuromycin

CAS 51959-56-9C₂₄H₃₀IN₇O₆

2-Amino-N-[5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-phenylpropanamide chemical structure, C19H23N7O4, CAS 26315-29-7

2-Amino-N-[5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-phenylpropanamide

CAS 26315-29-7C₁₉H₂₃N₇O₄

2-Amino-N-[5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide chemical structure, C20H25N7O5, CAS 28342-91-8

2-Amino-N-[5-(6-aminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide

CAS 28342-91-8C₂₀H₂₅N₇O₅

2-Acetamido-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide chemical structure, C24H31N7O6, CAS 7467-10-9

2-Acetamido-N-[5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide

CAS 7467-10-9C₂₄H₃₁N₇O₆

Puromycin chemical structure, C22H29N7O5, CAS 53-79-2

CAS 53-79-2C₂₂H₂₉N₇O₅

O-Demethylpuromycin chemical structure, C21H27N7O5, CAS 3598-42-3

O-Demethylpuromycin

CAS 3598-42-3C₂₁H₂₇N₇O₅

Puromycin hydrochloride chemical structure, C22H31Cl2N7O5, CAS 58-58-2

Puromycin hydrochloride

CAS 58-58-2C₂₂H₃₁Cl₂N₇O₅

2-Amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9-purinyl]-4-hydroxy-2-(hydroxymethyl)-3-oxolanyl]-3-(4-methoxyphenyl)propanamide chemical structure, C22H29N7O5, CAS 5682-30-4

2-Amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9-purinyl]-4-hydroxy-2-(hydroxymethyl)-3-oxolanyl]-3-(4-methoxyphenyl)propanamide

CAS 5682-30-4C₂₂H₂₉N₇O₅

FR-48736 dihydrochloride chemical structure, C20H25Cl2N7O6, CAS 86936-92-7

FR-48736 dihydrochloride

CAS 86936-92-7C₂₀H₂₅Cl₂N₇O₆

Puromycin monohydrochloride chemical structure, C22H30ClN7O5, CAS 3506-23-8

Puromycin monohydrochloride

CAS 3506-23-8C₂₂H₃₀ClN₇O₅

N-Acetylpuromycin chemical structure, C24H31N7O6, CAS 22852-13-7

N-Acetylpuromycin

CAS 22852-13-7C₂₄H₃₁N₇O₆

3'-Deoxy-3'-{[(2S)-2-hydroxy-3-phenylpropanoyl]amino}adenosine chemical structure, C19H22N6O5, CAS 918803-33-5

3'-Deoxy-3'-{[(2S)-2-hydroxy-3-phenylpropanoyl]amino}adenosine

CAS 918803-33-5C₁₉H₂₂N₆O₅

O-Propargyl-puromycin chemical structure, C24H29N7O5, CAS 1416561-90-4

O-Propargyl-puromycin

CAS 1416561-90-4C₂₄H₂₉N₇O₅

3'-Deoxy-3'-[[3-(4-methoxyphenyl)-1-oxopropyl]amino]-adenosine chemical structure, C20H24N6O5, CAS 168906-95-4

3'-Deoxy-3'-[[3-(4-methoxyphenyl)-1-oxopropyl]amino]-adenosine

CAS 168906-95-4C₂₀H₂₄N₆O₅