Murcko scaffold

2-((6-Benzyl-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-phenylacetamide scaffold

141 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 34
Chemicals: 141
With full pages: 3

Scaffold SMILES

O=C(CSc1ncc2c(n1)-c1ccccc1N(Cc1ccccc1)S2(=O)=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-((6-Benzyl-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-phenylacetamide page

Murcko scaffold O=C(CSc1ncc2c(n1)-c1ccccc1N(Cc1ccccc1)S2(=O)=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 141 chemicals

$2-({9-[(3-Fluorophenyl)methyl]-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-phenylacetamide chemical structure, C25H19FN4O3S2, CAS 895098-77-8$

2-({9-[(3-Fluorophenyl)methyl]-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-phenylacetamide

CAS 895098-77-8C₂₅H₁₉FN₄O₃S₂

2-((6-(3-Fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(o-tolyl)acetamide

CAS 895098-82-5C₂₆H₂₁FN₄O₃S₂

2-((6-(3-Fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(m-tolyl)acetamide

CAS 895098-87-0C₂₆H₂₁FN₄O₃S₂

2-((6-(3-Fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(p-tolyl)acetamide

CAS 895098-92-7C₂₆H₂₁FN₄O₃S₂

2-((6-(3-Fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(2-methoxyphenyl)acetamide

CAS 895098-97-2C₂₆H₂₁FN₄O₄S₂

2-((6-(3-Fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(3-methoxyphenyl)acetamide

CAS 895099-02-2C₂₆H₂₁FN₄O₄S₂

2-((6-(3-Fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(4-methoxyphenyl)acetamide

CAS 895099-07-7C₂₆H₂₁FN₄O₄S₂

N-(4-Chlorophenyl)-2-{[6-(3-fluorobenzyl)-5,5-dioxido-6H-pyrimido[5,4-c][2,1]benzothiazin-2-yl]thio}acetamide

CAS 895099-22-6C₂₅H₁₈ClFN₄O₃S₂

2-{[6-(3-Fluorobenzyl)-5,5-dioxido-6H-pyrimido[5,4-c][2,1]benzothiazin-2-yl]thio}-N-(2-fluorophenyl)acetamide

CAS 895099-27-1C₂₅H₁₈F₂N₄O₃S₂

2-((6-(3-Fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(4-fluorophenyl)acetamide

CAS 895099-37-3C₂₅H₁₈F₂N₄O₃S₂

N-(3,4-Dimethylphenyl)-2-((6-(3-fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 895099-42-0C₂₇H₂₃FN₄O₃S₂

N-(2,3-Dimethylphenyl)-2-((6-(3-fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 932476-05-6C₂₇H₂₃FN₄O₃S₂

N-(2,4-Dimethylphenyl)-2-((6-(3-fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 932529-12-9C₂₇H₂₃FN₄O₃S₂

N-(2-Ethylphenyl)-2-((6-(3-fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 932448-85-6C₂₇H₂₃FN₄O₃S₂

N-(4-Ethylphenyl)-2-((6-(3-fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 932529-17-4C₂₇H₂₃FN₄O₃S₂

2-{[6-(3-Fluorobenzyl)-5,5-dioxido-6H-pyrimido[5,4-c][2,1]benzothiazin-2-yl]sulfanyl}-N-(4-fluoro-2-methylphenyl)acetamide

CAS 932476-11-4C₂₆H₂₀F₂N₄O₃S₂

$2-({9-[(3-Methylphenyl)methyl]-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-phenylacetamide chemical structure, C26H22N4O3S2, CAS 895099-62-4$