Murcko scaffold

2-((6-Benzyl-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-phenylacetamide scaffold

141 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 34
Chemicals: 141
With full pages: 3

Scaffold SMILES

O=C(CSc1ncc2c(n1)-c1ccccc1N(Cc1ccccc1)S2(=O)=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-((6-Benzyl-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-phenylacetamide page

Murcko scaffold O=C(CSc1ncc2c(n1)-c1ccccc1N(Cc1ccccc1)S2(=O)=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 141 chemicals

2-((6-(3-Methoxybenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(m-tolyl)acetamide

CAS 892312-37-7C₂₇H₂₄N₄O₄S₂

N-(2-Chlorophenyl)-2-((6-(3-methoxybenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 892312-72-0C₂₆H₂₁ClN₄O₄S₂

N-(3-Chloro-4-methoxyphenyl)-2-((6-(4-methylbenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 959487-75-3C₂₇H₂₃ClN₄O₄S₂

2-((6-Benzyl-8-chloro-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(3,5-dimethoxyphenyl)acetamide

CAS 959556-33-3C₂₇H₂₃ClN₄O₅S₂

2-((6-Benzyl-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-phenylacetamide

CAS 950470-52-7C₂₅H₂₀N₄O₃S₂

N-(2,3-Dimethylphenyl)-2-((6-(4-fluorobenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 895098-15-4C₂₇H₂₃FN₄O₃S₂

2-{[6-(3-Fluorobenzyl)-5,5-dioxido-6H-pyrimido[5,4-c][2,1]benzothiazin-2-yl]sulfanyl}-N-(3-fluoro-4-methylphenyl)acetamide

CAS 895099-52-2C₂₆H₂₀F₂N₄O₃S₂

N-(2-Methoxyphenyl)-2-((6-(2-methylbenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 895100-13-7C₂₇H₂₄N₄O₄S₂

N-(2,5-Dimethylphenyl)-2-((6-(2-methylbenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 895100-63-7C₂₈H₂₆N₄O₃S₂

N-(4-Ethoxyphenyl)-2-((6-(2-methylbenzyl)-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)acetamide

CAS 895100-83-1C₂₈H₂₆N₄O₄S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(2-methylphenyl)acetamide chemical structure, C26H22N4O3S2, CAS 932313-35-4$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(2-methylphenyl)acetamide

CAS 932313-35-4C₂₆H₂₂N₄O₃S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(3-methylphenyl)acetamide chemical structure, C26H22N4O3S2, CAS 932475-72-4$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(3-methylphenyl)acetamide

CAS 932475-72-4C₂₆H₂₂N₄O₃S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(4-methylphenyl)acetamide chemical structure, C26H22N4O3S2, CAS 932528-61-5$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(4-methylphenyl)acetamide

CAS 932528-61-5C₂₆H₂₂N₄O₃S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(2-methoxyphenyl)acetamide chemical structure, C26H22N4O4S2, CAS 932448-42-5$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(2-methoxyphenyl)acetamide

CAS 932448-42-5C₂₆H₂₂N₄O₄S₂

2-((6-Benzyl-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(3-methoxyphenyl)acetamide

CAS 932313-38-7C₂₆H₂₂N₄O₄S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(4-methoxyphenyl)acetamide chemical structure, C26H22N4O4S2, CAS 932475-75-7$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(4-methoxyphenyl)acetamide

CAS 932475-75-7C₂₆H₂₂N₄O₄S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(4-chlorophenyl)acetamide chemical structure, C25H19ClN4O3S2, CAS 932448-45-8$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(4-chlorophenyl)acetamide

CAS 932448-45-8C₂₅H₁₉ClN₄O₃S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(3-fluorophenyl)acetamide chemical structure, C25H19FN4O3S2, CAS 932528-69-3$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(3-fluorophenyl)acetamide

CAS 932528-69-3C₂₅H₁₉FN₄O₃S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(4-fluorophenyl)acetamide chemical structure, C25H19FN4O3S2, CAS 932313-44-5$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(4-fluorophenyl)acetamide

CAS 932313-44-5C₂₅H₁₉FN₄O₃S₂

SMSSF-0601726

CAS 932448-49-2C₂₅H₁₈ClFN₄O₃S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(3,4-dimethoxyphenyl)acetamide chemical structure, C27H24N4O5S2, CAS 932475-81-5$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(3,4-dimethoxyphenyl)acetamide

CAS 932475-81-5C₂₇H₂₄N₄O₅S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(3,4-dimethylphenyl)acetamide chemical structure, C27H24N4O3S2, CAS 932313-47-8$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(3,4-dimethylphenyl)acetamide

CAS 932313-47-8C₂₇H₂₄N₄O₃S₂

$2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(2,5-dimethylphenyl)acetamide chemical structure, C27H24N4O3S2, CAS 932448-53-8$

2-({9-Benzyl-8,8-dioxo-8lambda6-thia-3,5,9-triazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2(7),3,5,10,12-hexaen-4-yl}sulfanyl)-N-(2,5-dimethylphenyl)acetamide

CAS 932448-53-8C₂₇H₂₄N₄O₃S₂

2-((6-Benzyl-5,5-dioxido-6H-benzo[c]pyrimido[4,5-e][1,2]thiazin-2-yl)thio)-N-(3-chloro-4-methylphenyl)acetamide

CAS 932475-84-8C₂₆H₂₁ClN₄O₃S₂