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Murcko scaffold

Ring system with 4 rings and 25 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
16
With full pages
3
Scaffold SMILES

O=C(Cc1ccccc1)Nc1ccc2oc(-c3ccccc3)nc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cc1ccccc1)Nc1ccc2oc(-c3ccccc3)nc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

N-[2-(4-Methylphenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C22H18N2O2, CAS 5720-13-8
N-[2-(4-Methylphenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 5720-13-8C22H18N2O2
N-[2-(2-Fluorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C21H15FN2O2, CAS 352666-69-4
N-[2-(2-Fluorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 352666-69-4C21H15FN2O2
N-[2-(2-Chlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C21H15ClN2O2, CAS 309292-63-5
N-[2-(2-Chlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 309292-63-5C21H15ClN2O2
N-[2-(4-Bromophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C21H15BrN2O2, CAS 332042-48-5
N-[2-(4-Bromophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 332042-48-5C21H15BrN2O2
N-[2-(2-Chloro-4,5-difluorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C21H13ClF2N2O2, CAS 527692-36-0
N-[2-(2-Chloro-4,5-difluorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 527692-36-0C21H13ClF2N2O2
N-[2-(3,4-Dimethylphenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C23H20N2O2, CAS 532423-45-3
N-[2-(3,4-Dimethylphenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 532423-45-3C23H20N2O2
N-[2-(3-Chloro-4-methylphenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C22H17ClN2O2, CAS 431983-75-4
N-[2-(3-Chloro-4-methylphenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 431983-75-4C22H17ClN2O2
N-[2-(4-Methoxyphenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C22H18N2O3, CAS 433962-69-7
N-[2-(4-Methoxyphenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 433962-69-7C22H18N2O3
2-(4-Chlorophenyl)-N-{2-[4-(dimethylamino)phenyl]-1,3-benzoxazol-5-yl}acetamide chemical structure, C23H20ClN3O2, CAS 673455-03-3
2-(4-Chlorophenyl)-N-{2-[4-(dimethylamino)phenyl]-1,3-benzoxazol-5-yl}acetamide
CAS 673455-03-3C23H20ClN3O2
2-(4-Chlorophenyl)-N-[2-(2-fluorophenyl)-1,3-benzoxazol-5-yl]acetamide chemical structure, C21H14ClFN2O2, CAS 425645-94-9
2-(4-Chlorophenyl)-N-[2-(2-fluorophenyl)-1,3-benzoxazol-5-yl]acetamide
CAS 425645-94-9C21H14ClFN2O2
2-(4-Chlorophenyl)-N-[2-(3-chlorophenyl)-1,3-benzoxazol-5-yl]acetamide chemical structure, C21H14Cl2N2O2, CAS 425646-04-4
2-(4-Chlorophenyl)-N-[2-(3-chlorophenyl)-1,3-benzoxazol-5-yl]acetamide
CAS 425646-04-4C21H14Cl2N2O2
2-(4-Chlorophenyl)-N-[2-(3-methylphenyl)-1,3-benzoxazol-5-yl]acetamide chemical structure, C22H17ClN2O2, CAS 403709-84-2
2-(4-Chlorophenyl)-N-[2-(3-methylphenyl)-1,3-benzoxazol-5-yl]acetamide
CAS 403709-84-2C22H17ClN2O2
N-[2-(2,4-Dichlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C21H14Cl2N2O2, CAS 388086-13-3
N-[2-(2,4-Dichlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 388086-13-3C21H14Cl2N2O2
N-[2-(3-Bromophenyl)-1,3-benzoxazol-5-yl]-2-(4-chlorophenyl)acetamide chemical structure, C21H14BrClN2O2, CAS 425653-84-5
N-[2-(3-Bromophenyl)-1,3-benzoxazol-5-yl]-2-(4-chlorophenyl)acetamide
CAS 425653-84-5C21H14BrClN2O2
2-(4-Nitrophenyl)-N-(2-phenyl-1,3-benzoxazol-5-yl)acetamide chemical structure, C21H15N3O4, CAS 301647-03-0
2-(4-Nitrophenyl)-N-(2-phenyl-1,3-benzoxazol-5-yl)acetamide
CAS 301647-03-0C21H15N3O4
N-[2-(2-Chloro-5-iodophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide chemical structure, C21H14ClIN2O2, CAS 388086-14-4
N-[2-(2-Chloro-5-iodophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
CAS 388086-14-4C21H14ClIN2O2