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Murcko scaffold

Ring system with 4 rings and 26 atoms

278 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
278
With full pages
5
Scaffold SMILES

O=C(Cn1ccn2nc(-c3ccccc3)cc2c1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1ccn2nc(-c3ccccc3)cc2c1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 278 chemicals

2-[2-(4-Methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]-N-(3-methylphenyl)acetamide chemical structure, C22H20N4O3, CAS 932287-56-4
2-[2-(4-Methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]-N-(3-methylphenyl)acetamide
CAS 932287-56-4C22H20N4O3
2-[2-(4-Methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-methylphenyl)acetamide chemical structure, C22H20N4O3, CAS 941955-78-8
2-[2-(4-Methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(4-methylphenyl)acetamide
CAS 941955-78-8C22H20N4O3
N-(3-Methoxyphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide chemical structure, C22H20N4O4, CAS 941913-31-1
N-(3-Methoxyphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide
CAS 941913-31-1C22H20N4O4
N-(2,3-Dimethylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide chemical structure, C23H22N4O3, CAS 932287-65-5
N-(2,3-Dimethylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide
CAS 932287-65-5C23H22N4O3
N-(2,4-Dimethylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C23H22N4O3, CAS 942035-06-5
N-(2,4-Dimethylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 942035-06-5C23H22N4O3
N-(4-Ethoxyphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C23H22N4O4, CAS 941955-87-9
N-(4-Ethoxyphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941955-87-9C23H22N4O4
N-(2,6-Dimethylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide chemical structure, C23H22N4O3, CAS 932524-61-3
N-(2,6-Dimethylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide
CAS 932524-61-3C23H22N4O3
N-(3-Ethylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide chemical structure, C23H22N4O3, CAS 941907-23-9
N-(3-Ethylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide
CAS 941907-23-9C23H22N4O3
N-(2-Ethoxyphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide chemical structure, C23H22N4O4, CAS 941956-26-9
N-(2-Ethoxyphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide
CAS 941956-26-9C23H22N4O4
N-(2-Methoxy-5-methylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide chemical structure, C23H22N4O4, CAS 942035-32-7
N-(2-Methoxy-5-methylphenyl)-2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5-yl]acetamide
CAS 942035-32-7C23H22N4O4
N-(3-Acetylphenyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C22H18N4O3, CAS 941920-58-7
N-(3-Acetylphenyl)-2-(4-oxo-2-phenylpyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941920-58-7C22H18N4O3
Methyl 4-({[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetyl}amino)benzoate chemical structure, C23H20N4O5, CAS 941907-04-6
Methyl 4-({[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetyl}amino)benzoate
CAS 941907-04-6C23H20N4O5
N-(2,6-Dimethylphenyl)-2-[2-(4-ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide chemical structure, C24H24N4O3, CAS 941938-49-4
N-(2,6-Dimethylphenyl)-2-[2-(4-ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]acetamide
CAS 941938-49-4C24H24N4O3
Ethyl 2-{2-[2-(4-ethoxyphenyl)-4-oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl]acetamido}benzoate chemical structure, C25H24N4O5, CAS 941876-61-5
Ethyl 2-{2-[2-(4-ethoxyphenyl)-4-oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl]acetamido}benzoate
CAS 941876-61-5C25H24N4O5
N-(2,5-Difluorophenyl)-2-(2-(3,4-dimethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C22H18F2N4O4, CAS 941876-81-9
N-(2,5-Difluorophenyl)-2-(2-(3,4-dimethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941876-81-9C22H18F2N4O4
2-[2-(3,4-Dimethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(3-ethylphenyl)acetamide chemical structure, C24H24N4O4, CAS 941876-83-1
2-[2-(3,4-Dimethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(3-ethylphenyl)acetamide
CAS 941876-83-1C24H24N4O4
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(3,5-dimethoxyphenyl)acetamide chemical structure, C26H28N4O5, CAS 941977-36-2
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(3,5-dimethoxyphenyl)acetamide
CAS 941977-36-2C26H28N4O5
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(3-chloro-4-methylphenyl)acetamide chemical structure, C25H25ClN4O3, CAS 941886-76-6
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(3-chloro-4-methylphenyl)acetamide
CAS 941886-76-6C25H25ClN4O3
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(4-methoxyphenyl)acetamide chemical structure, C25H26N4O4, CAS 941933-96-6
2-(2-(4-Butoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-(4-methoxyphenyl)acetamide
CAS 941933-96-6C25H26N4O4
2-[2-(4-Butoxyphenyl)-4-oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl]-N-(3-chloro-4-methoxyphenyl)acetamide chemical structure, C25H25ClN4O4, CAS 941977-40-8
2-[2-(4-Butoxyphenyl)-4-oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl]-N-(3-chloro-4-methoxyphenyl)acetamide
CAS 941977-40-8C25H25ClN4O4
N-(2-Ethoxyphenyl)-2-(4-oxo-2-(p-tolyl)pyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide chemical structure, C23H22N4O3, CAS 941963-78-6
N-(2-Ethoxyphenyl)-2-(4-oxo-2-(p-tolyl)pyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamide
CAS 941963-78-6C23H22N4O3
Ethyl 2-(2-(2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamido)benzoate chemical structure, C24H22N4O5, CAS 941938-30-3
Ethyl 2-(2-(2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetamido)benzoate
CAS 941938-30-3C24H22N4O5
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(2-methoxyphenyl)acetamide chemical structure, C23H22N4O4, CAS 941938-42-7
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(2-methoxyphenyl)acetamide
CAS 941938-42-7C23H22N4O4
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(3-methoxyphenyl)acetamide chemical structure, C23H22N4O4, CAS 941876-41-1
2-[2-(4-Ethoxyphenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(3-methoxyphenyl)acetamide
CAS 941876-41-1C23H22N4O4