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Murcko scaffold

Ring system with 3 rings and 21 atoms

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
24
With full pages
5
Scaffold SMILES

O=C(Nc1nncs1)C1CC(=O)N(Cc2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nncs1)C1CC(=O)N(Cc2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

1-Benzyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxo-3-pyrrolidinecarboxamide chemical structure, C15H16N4O2S, CAS 839689-35-9
1-Benzyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxo-3-pyrrolidinecarboxamide
CAS 839689-35-9C15H16N4O2S
N-(5-Methyl-1,3,4-thiadiazol-2-yl)-5-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C16H18N4O2S, CAS 839689-72-4
N-(5-Methyl-1,3,4-thiadiazol-2-yl)-5-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide
CAS 839689-72-4C16H18N4O2S
1-Benzyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H18N4O2S, CAS 851712-10-2
1-Benzyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 851712-10-2C16H18N4O2S
1-[(2-Chlorophenyl)methyl]-5-oxo-N-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide chemical structure, C17H19ClN4O2S, CAS 1015151-56-0
1-[(2-Chlorophenyl)methyl]-5-oxo-N-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]pyrrolidine-3-carboxamide
CAS 1015151-56-0C17H19ClN4O2S
1-Benzyl-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-5-oxopyrrolidine-3-carboxamide chemical structure, C18H22N4O2S, CAS 1016477-04-5
1-Benzyl-N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-5-oxopyrrolidine-3-carboxamide
CAS 1016477-04-5C18H22N4O2S
1-Benzyl-N-(5-butyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H22N4O2S, CAS 1031099-43-0
1-Benzyl-N-(5-butyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 1031099-43-0C18H22N4O2S
1-(4-Chlorobenzyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H15ClN4O2S, CAS 1144446-45-6
1-(4-Chlorobenzyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 1144446-45-6C15H15ClN4O2S
1-(4-Chlorobenzyl)-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide chemical structure, C16H17ClN4O3S, CAS 1144429-17-3
1-(4-Chlorobenzyl)-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide
CAS 1144429-17-3C16H17ClN4O3S
1-(4-Fluorobenzyl)-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide chemical structure, C16H17FN4O3S, CAS 1144467-35-5
1-(4-Fluorobenzyl)-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide
CAS 1144467-35-5C16H17FN4O3S
1-(4-Chlorobenzyl)-5-oxo-N-[(2E)-5-(propan-2-yl)-1,3,4-thiadiazol-2(3H)-ylidene]pyrrolidine-3-carboxamide chemical structure, C17H19ClN4O2S, CAS 1144496-47-8
1-(4-Chlorobenzyl)-5-oxo-N-[(2E)-5-(propan-2-yl)-1,3,4-thiadiazol-2(3H)-ylidene]pyrrolidine-3-carboxamide
CAS 1144496-47-8C17H19ClN4O2S
1-Benzyl-5-oxo-N-[(2E)-5-(propan-2-yl)-1,3,4-thiadiazol-2(3H)-ylidene]pyrrolidine-3-carboxamide chemical structure, C17H20N4O2S, CAS 1144486-31-6
1-Benzyl-5-oxo-N-[(2E)-5-(propan-2-yl)-1,3,4-thiadiazol-2(3H)-ylidene]pyrrolidine-3-carboxamide
CAS 1144486-31-6C17H20N4O2S
1-(2-Methoxybenzyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H18N4O3S, CAS 1144486-56-5
1-(2-Methoxybenzyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 1144486-56-5C16H18N4O3S
1-Benzyl-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide chemical structure, C16H18N4O3S, CAS 1144432-94-9
1-Benzyl-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide
CAS 1144432-94-9C16H18N4O3S
1-(4-Chlorobenzyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H17ClN4O2S, CAS 1144490-20-9
1-(4-Chlorobenzyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 1144490-20-9C16H17ClN4O2S
1-(2-Chlorobenzyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H17ClN4O2S, CAS 1144498-65-6
1-(2-Chlorobenzyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 1144498-65-6C16H17ClN4O2S
1-(4-Fluorobenzyl)-5-oxo-N-[(2E)-5-(propan-2-yl)-1,3,4-thiadiazol-2(3H)-ylidene]pyrrolidine-3-carboxamide chemical structure, C17H19FN4O2S, CAS 1144455-41-3
1-(4-Fluorobenzyl)-5-oxo-N-[(2E)-5-(propan-2-yl)-1,3,4-thiadiazol-2(3H)-ylidene]pyrrolidine-3-carboxamide
CAS 1144455-41-3C17H19FN4O2S
1-(2-Methoxybenzyl)-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide chemical structure, C17H20N4O4S, CAS 1144455-86-6
1-(2-Methoxybenzyl)-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide
CAS 1144455-86-6C17H20N4O4S
1-(2-Chlorobenzyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H15ClN4O2S, CAS 1144445-47-5
1-(2-Chlorobenzyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 1144445-47-5C15H15ClN4O2S
1-(2-Chlorobenzyl)-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide chemical structure, C16H17ClN4O3S, CAS 1144428-80-7
1-(2-Chlorobenzyl)-N-[(2E)-5-(methoxymethyl)-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide
CAS 1144428-80-7C16H17ClN4O3S
1-(4-Fluorobenzyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C15H15FN4O2S, CAS 1144436-63-4
1-(4-Fluorobenzyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide
CAS 1144436-63-4C15H15FN4O2S
N-[(2E)-5-tert-Butyl-1,3,4-thiadiazol-2(3H)-ylidene]-1-(4-fluorobenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H21FN4O2S, CAS 1190274-57-7
N-[(2E)-5-tert-Butyl-1,3,4-thiadiazol-2(3H)-ylidene]-1-(4-fluorobenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 1190274-57-7C18H21FN4O2S
1-Benzyl-N-[(2E)-5-tert-butyl-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide chemical structure, C18H22N4O2S, CAS 1190266-67-1
1-Benzyl-N-[(2E)-5-tert-butyl-1,3,4-thiadiazol-2(3H)-ylidene]-5-oxopyrrolidine-3-carboxamide
CAS 1190266-67-1C18H22N4O2S
N-[(2E)-5-tert-Butyl-1,3,4-thiadiazol-2(3H)-ylidene]-1-(2-methoxybenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H24N4O3S, CAS 1190288-56-2
N-[(2E)-5-tert-Butyl-1,3,4-thiadiazol-2(3H)-ylidene]-1-(2-methoxybenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 1190288-56-2C19H24N4O3S
N-[(2E)-5-tert-Butyl-1,3,4-thiadiazol-2(3H)-ylidene]-1-(4-chlorobenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H21ClN4O2S, CAS 1190248-78-2
N-[(2E)-5-tert-Butyl-1,3,4-thiadiazol-2(3H)-ylidene]-1-(4-chlorobenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 1190248-78-2C18H21ClN4O2S