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Murcko scaffold

6-(Pyrrolidin-1-yl)pyrimidine-2,4(1H,3H)-dione scaffold

33 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 13
Chemicals: 33
With full pages: 3

Scaffold SMILES

O=c1cc(N2CCCC2)[nH]c(=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 6-(Pyrrolidin-1-yl)pyrimidine-2,4(1H,3H)-dione page

Murcko scaffold O=c1cc(N2CCCC2)[nH]c(=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

3-Methyl-6-pyrrolidin-1-yl-1H-pyrimidine-2,4-dione chemical structure, C9H13N3O2, CAS 218447-54-2

3-Methyl-6-pyrrolidin-1-yl-1H-pyrimidine-2,4-dione

CAS 218447-54-2C₉H₁₃N₃O₂

1,3-Dimethyl-2,4-dioxo-6-(pyrrolidin-1-yl)-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde chemical structure, C11H15N3O3, CAS 193696-10-5

1,3-Dimethyl-2,4-dioxo-6-(pyrrolidin-1-yl)-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde

CAS 193696-10-5C₁₁H₁₅N₃O₃

6-(3-Aminopyrrolidin-1-yl)-3-methylpyrimidine-2,4(1H,3H)-dione chemical structure, C9H14N4O2, CAS 1338671-41-2

6-(3-Aminopyrrolidin-1-yl)-3-methylpyrimidine-2,4(1H,3H)-dione

CAS 1338671-41-2C₉H₁₄N₄O₂

6-(Pyrrolidin-1-yl)pyrimidine-2,4(1H,3H)-dione chemical structure, C8H11N3O2, CAS 1797804-30-8

6-(Pyrrolidin-1-yl)pyrimidine-2,4(1H,3H)-dione

CAS 1797804-30-8C₈H₁₁N₃O₂

6-[(3S)-3-Aminopyrrolidin-1-yl]-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C9H14N4O2, CAS 2375248-43-2

6-[(3S)-3-Aminopyrrolidin-1-yl]-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2375248-43-2C₉H₁₄N₄O₂

6-[(3R)-3-Aminopyrrolidin-1-yl]-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C9H14N4O2, CAS 2375248-40-9

6-[(3R)-3-Aminopyrrolidin-1-yl]-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2375248-40-9C₉H₁₄N₄O₂

6-[(3R)-3-Aminopyrrolidin-1-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C8H12N4O2, CAS 2361609-41-6

6-[(3R)-3-Aminopyrrolidin-1-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2361609-41-6C₈H₁₂N₄O₂

6-[(3S)-3-Aminopyrrolidin-1-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C8H12N4O2, CAS 2361608-71-9

6-[(3S)-3-Aminopyrrolidin-1-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2361608-71-9C₈H₁₂N₄O₂

6-(3-Aminopyrrolidin-1-yl)-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione dihydrochloride chemical structure, C9H16Cl2N4O2, CAS 2137757-59-4

6-(3-Aminopyrrolidin-1-yl)-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione dihydrochloride

CAS 2137757-59-4C₉H₁₆Cl₂N₄O₂

6-[(3S)-3-Aminopyrrolidin-1-yl]-1,3-dimethylpyrimidine-2,4-dione, dihydrochloride chemical structure, C10H18Cl2N4O2, CAS 2361610-22-0

6-[(3S)-3-Aminopyrrolidin-1-yl]-1,3-dimethylpyrimidine-2,4-dione, dihydrochloride

CAS 2361610-22-0C₁₀H₁₈Cl₂N₄O₂

6-[(3S)-3-Aminopyrrolidin-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C10H16N4O2, CAS 2137032-97-2

6-[(3S)-3-Aminopyrrolidin-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2137032-97-2C₁₀H₁₆N₄O₂

6-[(3S)-3-Aminopyrrolidin-1-yl]-1H-pyrimidine-2,4-dione, hydrochloride chemical structure, C8H13ClN4O2, CAS 2361609-68-7

6-[(3S)-3-Aminopyrrolidin-1-yl]-1H-pyrimidine-2,4-dione, hydrochloride

CAS 2361609-68-7C₈H₁₃ClN₄O₂

6-[(3R)-3-Aminopyrrolidin-1-yl]-1H-pyrimidine-2,4-dione, dihydrochloride chemical structure, C8H14Cl2N4O2, CAS 2361609-78-9

6-[(3R)-3-Aminopyrrolidin-1-yl]-1H-pyrimidine-2,4-dione, dihydrochloride

CAS 2361609-78-9C₈H₁₄Cl₂N₄O₂

6-[(3R)-3-Aminopyrrolidin-1-yl]-1,3-dimethylpyrimidine-2,4-dione, dihydrochloride chemical structure, C10H18Cl2N4O2, CAS 2361577-98-0

6-[(3R)-3-Aminopyrrolidin-1-yl]-1,3-dimethylpyrimidine-2,4-dione, dihydrochloride

CAS 2361577-98-0C₁₀H₁₈Cl₂N₄O₂

6-[(3R)-3-Aminopyrrolidin-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C10H16N4O2, CAS 2137072-59-2

6-[(3R)-3-Aminopyrrolidin-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2137072-59-2C₁₀H₁₆N₄O₂

6-[(3S)-3-Aminopyrrolidin-1-yl]-3-methyl-1H-pyrimidine-2,4-dione, hydrochloride chemical structure, C9H15ClN4O2, CAS 2375248-44-3

6-[(3S)-3-Aminopyrrolidin-1-yl]-3-methyl-1H-pyrimidine-2,4-dione, hydrochloride

CAS 2375248-44-3C₉H₁₅ClN₄O₂

6-[(3R)-3-Aminopyrrolidin-1-yl]-3-ethyl-1H-pyrimidine-2,4-dione, dihydrochloride chemical structure, C10H18Cl2N4O2, CAS 2375247-79-1

6-[(3R)-3-Aminopyrrolidin-1-yl]-3-ethyl-1H-pyrimidine-2,4-dione, dihydrochloride

CAS 2375247-79-1C₁₀H₁₈Cl₂N₄O₂

6-[(3R)-3-Aminopyrrolidin-1-yl]-3-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C10H16N4O2, CAS 2375247-78-0

6-[(3R)-3-Aminopyrrolidin-1-yl]-3-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2375247-78-0C₁₀H₁₆N₄O₂

6-[(3R)-3-Aminopyrrolidin-1-yl]-3-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride chemical structure, C10H17ClN4O2, CAS 2375250-96-5

6-[(3R)-3-Aminopyrrolidin-1-yl]-3-ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride

CAS 2375250-96-5C₁₀H₁₇ClN₄O₂

N-tert-Butyl-1-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)pyrrolidine-3-carboxamide chemical structure, C15H24N4O3, CAS 2741934-22-3

N-tert-Butyl-1-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)pyrrolidine-3-carboxamide

CAS 2741934-22-3C₁₅H₂₄N₄O₃

6-(3,3-Difluoropyrrolidin-1-yl)-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C10H13F2N3O2, CAS 2741931-49-5

6-(3,3-Difluoropyrrolidin-1-yl)-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2741931-49-5C₁₀H₁₃F₂N₃O₂

6-(3,3-Difluoropyrrolidin-1-yl)-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C9H11F2N3O2, CAS 2166700-23-6

6-(3,3-Difluoropyrrolidin-1-yl)-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2166700-23-6C₉H₁₁F₂N₃O₂

6-[3-(Hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione chemical structure, C10H15N3O3, CAS 2137547-61-4

6-[3-(Hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

CAS 2137547-61-4C₁₀H₁₅N₃O₃

Methyl 1-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)pyrrolidine-2-carboxylate chemical structure, C12H17N3O4, CAS 1243539-51-6

Methyl 1-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)pyrrolidine-2-carboxylate

CAS 1243539-51-6C₁₂H₁₇N₃O₄