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Murcko scaffold

[4-(Naphthalen-1-ylmethyl)piperazin-1-yl]-phenylmethanone scaffold

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
13
With full pages
1
Scaffold SMILES

O=C(c1ccccc1)N1CCN(Cc2cccc3ccccc23)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the [4-(Naphthalen-1-ylmethyl)piperazin-1-yl]-phenylmethanone page
Murcko scaffold O=C(c1ccccc1)N1CCN(Cc2cccc3ccccc23)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

[4-[(2-Methoxynaphthalen-1-yl)methyl]piperazin-1-yl]-phenylmethanone chemical structure, C23H24N2O2, CAS 332850-88-1
[4-[(2-Methoxynaphthalen-1-yl)methyl]piperazin-1-yl]-phenylmethanone
CAS 332850-88-1C23H24N2O2
[4-(Naphthalen-1-ylmethyl)piperazin-1-yl]-phenylmethanone chemical structure, C22H22N2O, CAS 352436-59-0
[4-(Naphthalen-1-ylmethyl)piperazin-1-yl]-phenylmethanone
CAS 352436-59-0C22H22N2O
(2-Fluorophenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone chemical structure, C22H21FN2O, CAS 354535-74-3
(2-Fluorophenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone
CAS 354535-74-3C22H21FN2O
(4-Fluorophenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone chemical structure, C22H21FN2O, CAS 352436-49-8
(4-Fluorophenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone
CAS 352436-49-8C22H21FN2O
(3,5-Dimethoxyphenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone chemical structure, C24H26N2O3, CAS 415942-51-7
(3,5-Dimethoxyphenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone
CAS 415942-51-7C24H26N2O3
(2-Methoxyphenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone chemical structure, C23H24N2O2, CAS 510720-97-5
(2-Methoxyphenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone
CAS 510720-97-5C23H24N2O2
(3-Fluorophenyl)-[4-[(2-methoxynaphthalen-1-yl)methyl]piperazin-1-yl]methanone chemical structure, C23H23FN2O2, CAS 354536-02-0
(3-Fluorophenyl)-[4-[(2-methoxynaphthalen-1-yl)methyl]piperazin-1-yl]methanone
CAS 354536-02-0C23H23FN2O2
[4-[(2-Methoxynaphthalen-1-yl)methyl]piperazin-1-yl]-(3-methoxyphenyl)methanone chemical structure, C24H26N2O3, CAS 355393-14-5
[4-[(2-Methoxynaphthalen-1-yl)methyl]piperazin-1-yl]-(3-methoxyphenyl)methanone
CAS 355393-14-5C24H26N2O3
(4-Methoxyphenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone chemical structure, C23H24N2O2, CAS 352436-57-8
(4-Methoxyphenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone
CAS 352436-57-8C23H24N2O2
[4-(Naphthalen-1-ylmethyl)piperazin-1-yl]-(4-nitrophenyl)methanone chemical structure, C22H21N3O3, CAS 356090-56-7
[4-(Naphthalen-1-ylmethyl)piperazin-1-yl]-(4-nitrophenyl)methanone
CAS 356090-56-7C22H21N3O3
(3,4-Dimethoxyphenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone chemical structure, C24H26N2O3, CAS 425390-15-4
(3,4-Dimethoxyphenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone
CAS 425390-15-4C24H26N2O3
(3-Chlorophenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone chemical structure, C22H21ClN2O, CAS 425397-99-5
(3-Chlorophenyl)-[4-(naphthalen-1-ylmethyl)piperazin-1-yl]methanone
CAS 425397-99-5C22H21ClN2O
[4-[(2-Methoxynaphthalen-1-yl)methyl]piperazin-1-yl]-(4-methoxyphenyl)methanone chemical structure, C24H26N2O3, CAS 352436-46-5
[4-[(2-Methoxynaphthalen-1-yl)methyl]piperazin-1-yl]-(4-methoxyphenyl)methanone
CAS 352436-46-5C24H26N2O3