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Murcko scaffold

Ring system with 4 rings and 26 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
12
With full pages
2
Scaffold SMILES

O=C(c1ccccc1)N1CCN(C(=O)c2cccc3ccccc23)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(C(=O)c2cccc3ccccc23)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

(3-Fluorophenyl)-[4-(naphthalene-1-carbonyl)piperazin-1-yl]methanone chemical structure, C22H19FN2O2, CAS 333756-52-8
(3-Fluorophenyl)-[4-(naphthalene-1-carbonyl)piperazin-1-yl]methanone
CAS 333756-52-8C22H19FN2O2
Naphthalen-1-yl-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]methanone chemical structure, C25H26N2O5, CAS 423743-31-1
Naphthalen-1-yl-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-yl]methanone
CAS 423743-31-1C25H26N2O5
(3-Chlorophenyl)-[4-(naphthalene-1-carbonyl)piperazin-1-yl]methanone chemical structure, C22H19ClN2O2, CAS 423734-84-3
(3-Chlorophenyl)-[4-(naphthalene-1-carbonyl)piperazin-1-yl]methanone
CAS 423734-84-3C22H19ClN2O2
1-(4-Fluorobenzoyl)-4-(1-naphthoyl)piperazine chemical structure, C22H19FN2O2, CAS 423735-79-9
1-(4-Fluorobenzoyl)-4-(1-naphthoyl)piperazine
CAS 423735-79-9C22H19FN2O2
1-(2-Methoxybenzoyl)-4-(1-naphthoyl)piperazine chemical structure, C23H22N2O3, CAS 423738-57-2
1-(2-Methoxybenzoyl)-4-(1-naphthoyl)piperazine
CAS 423738-57-2C23H22N2O3
1-(3,5-Dimethoxybenzoyl)-4-(1-naphthoyl)piperazine chemical structure, C24H24N2O4, CAS 333756-25-5
1-(3,5-Dimethoxybenzoyl)-4-(1-naphthoyl)piperazine
CAS 333756-25-5C24H24N2O4
1-(1-Naphthoyl)-4-(4-nitrobenzoyl)piperazine chemical structure, C22H19N3O4, CAS 423739-58-6
1-(1-Naphthoyl)-4-(4-nitrobenzoyl)piperazine
CAS 423739-58-6C22H19N3O4
1-(3-Methoxybenzoyl)-4-(1-naphthoyl)piperazine chemical structure, C23H22N2O3, CAS 333756-80-2
1-(3-Methoxybenzoyl)-4-(1-naphthoyl)piperazine
CAS 333756-80-2C23H22N2O3
1-(2-Fluorobenzoyl)-4-(1-naphthoyl)piperazine chemical structure, C22H19FN2O2, CAS 333756-94-8
1-(2-Fluorobenzoyl)-4-(1-naphthoyl)piperazine
CAS 333756-94-8C22H19FN2O2
1-(4-Methoxybenzoyl)-4-(1-naphthoyl)piperazine chemical structure, C23H22N2O3, CAS 333757-37-2
1-(4-Methoxybenzoyl)-4-(1-naphthoyl)piperazine
CAS 333757-37-2C23H22N2O3
1-(2,3-Dimethoxybenzoyl)-4-(1-naphthoyl)piperazine chemical structure, C24H24N2O4, CAS 333757-42-9
1-(2,3-Dimethoxybenzoyl)-4-(1-naphthoyl)piperazine
CAS 333757-42-9C24H24N2O4
1-(3,4-Dimethoxybenzoyl)-4-(1-naphthoyl)piperazine chemical structure, C24H24N2O4, CAS 333757-81-6
1-(3,4-Dimethoxybenzoyl)-4-(1-naphthoyl)piperazine
CAS 333757-81-6C24H24N2O4