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Murcko scaffold

Ring system with 4 rings and 27 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
9
With full pages
3
Scaffold SMILES

O=C(c1ccnc2ccccc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccnc2ccccc12)N1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

{4-[(4-Fluorophenyl)sulfonyl]piperazin-1-yl}(2-methylquinolin-4-yl)methanone chemical structure, C21H20FN3O3S, CAS 849625-70-3
{4-[(4-Fluorophenyl)sulfonyl]piperazin-1-yl}(2-methylquinolin-4-yl)methanone
CAS 849625-70-3C21H20FN3O3S
2-Chloro-4-[4-(3-fluorobenzenesulfonyl)piperazine-1-carbonyl]quinoline chemical structure, C20H17ClFN3O3S, CAS 927043-63-8
2-Chloro-4-[4-(3-fluorobenzenesulfonyl)piperazine-1-carbonyl]quinoline
CAS 927043-63-8C20H17ClFN3O3S
4-[4-(4-Bromobenzenesulfonyl)piperazine-1-carbonyl]-2-methylquinoline chemical structure, C21H20BrN3O3S, CAS 940265-65-6
4-[4-(4-Bromobenzenesulfonyl)piperazine-1-carbonyl]-2-methylquinoline
CAS 940265-65-6C21H20BrN3O3S
2-Chloro-4-[4-(2-nitrobenzenesulfonyl)piperazine-1-carbonyl]quinoline chemical structure, C20H17ClN4O5S, CAS 1090403-65-8
2-Chloro-4-[4-(2-nitrobenzenesulfonyl)piperazine-1-carbonyl]quinoline
CAS 1090403-65-8C20H17ClN4O5S
2-Chloro-4-{4-[3-(trifluoromethyl)benzenesulfonyl]piperazine-1-carbonyl}quinoline chemical structure, C21H17ClF3N3O3S, CAS 1031493-51-2
2-Chloro-4-{4-[3-(trifluoromethyl)benzenesulfonyl]piperazine-1-carbonyl}quinoline
CAS 1031493-51-2C21H17ClF3N3O3S
2-Chloro-4-[4-(3-nitrobenzenesulfonyl)piperazine-1-carbonyl]quinoline chemical structure, C20H17ClN4O5S, CAS 1031194-38-3
2-Chloro-4-[4-(3-nitrobenzenesulfonyl)piperazine-1-carbonyl]quinoline
CAS 1031194-38-3C20H17ClN4O5S
{4-[(4-Methoxyphenyl)sulfonyl]piperazino}(2-methyl-4-quinolyl)methanone chemical structure, C22H23N3O4S, CAS 1144463-24-0
{4-[(4-Methoxyphenyl)sulfonyl]piperazino}(2-methyl-4-quinolyl)methanone
CAS 1144463-24-0C22H23N3O4S
N-[4-({4-[(2-Methyl-4-quinolyl)carbonyl]piperazino}sulfonyl)phenyl]acetamide chemical structure, C23H24N4O4S, CAS 1144443-63-9
N-[4-({4-[(2-Methyl-4-quinolyl)carbonyl]piperazino}sulfonyl)phenyl]acetamide
CAS 1144443-63-9C23H24N4O4S
2-Chloro-4-[4-(2,6-difluorobenzenesulfonyl)piperazine-1-carbonyl]quinoline chemical structure, C20H16ClF2N3O3S, CAS 1118799-40-8
2-Chloro-4-[4-(2,6-difluorobenzenesulfonyl)piperazine-1-carbonyl]quinoline
CAS 1118799-40-8C20H16ClF2N3O3S