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Murcko scaffold

Ring system with 3 rings and 23 atoms

11 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
11
With full pages
3
Scaffold SMILES

O=C1CC(c2ccccc2)C=C(SCC(=O)Nc2nccs2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)C=C(SCC(=O)Nc2nccs2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

2-(3-Cyano-6-oxo-4-phenyl-1,4,5,6-tetrahydro-pyridin-2-ylsulfanyl)-N-thiazol-2-yl-acetamide chemical structure, C17H14N4O2S2, CAS 352330-66-6
2-(3-Cyano-6-oxo-4-phenyl-1,4,5,6-tetrahydro-pyridin-2-ylsulfanyl)-N-thiazol-2-yl-acetamide
CAS 352330-66-6C17H14N4O2S2
2-[[5-Cyano-4-(4-ethoxy-3-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C20H20N4O4S2, CAS 375349-26-1
2-[[5-Cyano-4-(4-ethoxy-3-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 375349-26-1C20H20N4O4S2
Methyl 4-(4-chlorophenyl)-5-cyano-2-oxo-6-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-3,4-dihydro-1H-pyridine-3-carboxylate chemical structure, C19H15ClN4O4S2, CAS 374770-78-2
Methyl 4-(4-chlorophenyl)-5-cyano-2-oxo-6-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-3,4-dihydro-1H-pyridine-3-carboxylate
CAS 374770-78-2C19H15ClN4O4S2
2-((3-Cyano-4-(2-fluorophenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C17H13FN4O2S2, CAS 683794-54-9
2-((3-Cyano-4-(2-fluorophenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 683794-54-9C17H13FN4O2S2
2-((3-Cyano-4-(3,4-dimethoxyphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C19H18N4O4S2, CAS 683794-70-9
2-((3-Cyano-4-(3,4-dimethoxyphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 683794-70-9C19H18N4O4S2
2-((3-Cyano-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C20H20N4O5S2, CAS 683794-44-7
2-((3-Cyano-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 683794-44-7C20H20N4O5S2
2-[[5-Cyano-4-(2-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C18H16N4O3S2, CAS 497229-78-4
2-[[5-Cyano-4-(2-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 497229-78-4C18H16N4O3S2
2-[[4-(4-Chlorophenyl)-5-cyano-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C17H13ClN4O2S2, CAS 702650-16-6
2-[[4-(4-Chlorophenyl)-5-cyano-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 702650-16-6C17H13ClN4O2S2
2-((3-Cyano-4-(2-ethoxyphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C19H18N4O3S2, CAS 361980-41-8
2-((3-Cyano-4-(2-ethoxyphenyl)-6-oxo-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 361980-41-8C19H18N4O3S2
Methyl 5-cyano-2-hydroxy-4-(2-methylphenyl)-6-{[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl}-3,4-dihydropyridine-3-carboxylate chemical structure, C20H18N4O4S2, CAS 375357-47-4
Methyl 5-cyano-2-hydroxy-4-(2-methylphenyl)-6-{[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl}-3,4-dihydropyridine-3-carboxylate
CAS 375357-47-4C20H18N4O4S2
Necrostatin-34 chemical structure, C18H16N4O2S2, CAS 375835-43-1
Necrostatin-34
CAS 375835-43-1C18H16N4O2S2