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Murcko scaffold

1-Phenyl-2-(pyrimidin-2-ylthio)ethanone scaffold

28 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
28
With full pages
13
Scaffold SMILES

O=C(CSc1ncccn1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-2-(pyrimidin-2-ylthio)ethanone page
Murcko scaffold O=C(CSc1ncccn1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 28 of 28 chemicals

2-[(4-Methylpyrimidin-2-yl)sulfanyl]-1-phenylethanone chemical structure, C13H12N2OS, CAS 13897-03-5
2-[(4-Methylpyrimidin-2-yl)sulfanyl]-1-phenylethanone
CAS 13897-03-5C13H12N2OS
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-nitrophenyl)ethanone chemical structure, C14H13N3O3S, CAS 325852-56-0
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-nitrophenyl)ethanone
CAS 325852-56-0C14H13N3O3S
1-(4-Chlorophenyl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]ethan-1-one chemical structure, C14H13ClN2OS, CAS 329079-58-5
1-(4-Chlorophenyl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]ethan-1-one
CAS 329079-58-5C14H13ClN2OS
Methyl 5-[2-(4,6-dimethylpyrimidin-2-ylthio)acetyl]-2-hydroxybenzoate chemical structure, C16H16N2O4S, CAS 400740-13-8
Methyl 5-[2-(4,6-dimethylpyrimidin-2-ylthio)acetyl]-2-hydroxybenzoate
CAS 400740-13-8C16H16N2O4S
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-1-(4-fluorophenyl)ethan-1-one chemical structure, C14H13FN2OS, CAS 428860-42-8
2-[(4,6-Dimethylpyrimidin-2-yl)sulfanyl]-1-(4-fluorophenyl)ethan-1-one
CAS 428860-42-8C14H13FN2OS
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-methoxy-3-methylphenyl)ethanone chemical structure, C16H18N2O2S, CAS 429652-66-4
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-methoxy-3-methylphenyl)ethanone
CAS 429652-66-4C16H18N2O2S
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-propan-2-ylphenyl)ethanone chemical structure, C17H20N2OS, CAS 429635-27-8
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-propan-2-ylphenyl)ethanone
CAS 429635-27-8C17H20N2OS
1-(3,4-Dihydroxyphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]ethanone chemical structure, C14H14N2O3S, CAS 430447-82-8
1-(3,4-Dihydroxyphenyl)-2-[(4,6-dimethyl-2-pyrimidinyl)thio]ethanone
CAS 430447-82-8C14H14N2O3S
1-Phenyl-2-(pyrimidin-2-ylthio)ethanone chemical structure, C12H10N2OS, CAS 199387-64-9
1-Phenyl-2-(pyrimidin-2-ylthio)ethanone
CAS 199387-64-9C12H10N2OS
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(2,4,6-trimethylphenyl)ethanone chemical structure, C17H20N2OS, CAS 459420-07-6
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(2,4,6-trimethylphenyl)ethanone
CAS 459420-07-6C17H20N2OS
4-Amino-2-(phenacylthio)-5-pyrimidinecarboxylic acid ethyl ester chemical structure, C15H15N3O3S, CAS 326923-58-4
4-Amino-2-(phenacylthio)-5-pyrimidinecarboxylic acid ethyl ester
CAS 326923-58-4C15H15N3O3S
1-(2,4-Dihydroxyphenyl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanone chemical structure, C14H14N2O3S, CAS 351192-50-2
1-(2,4-Dihydroxyphenyl)-2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanone
CAS 351192-50-2C14H14N2O3S
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-fluoro-3-methylphenyl)ethanone chemical structure, C15H15FN2OS, CAS 667887-70-9
2-(4,6-Dimethylpyrimidin-2-yl)sulfanyl-1-(4-fluoro-3-methylphenyl)ethanone
CAS 667887-70-9C15H15FN2OS
2-(4-Chloro-6-methyl-pyrimidin-2-ylsulfanyl)-1-phenyl-ethanone chemical structure, C13H11ClN2OS, CAS 482631-59-4
2-(4-Chloro-6-methyl-pyrimidin-2-ylsulfanyl)-1-phenyl-ethanone
CAS 482631-59-4C13H11ClN2OS
2-{[4-Methyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}-1-phenylethan-1-one chemical structure, C14H11F3N2OS, CAS 717862-97-0
2-{[4-Methyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}-1-phenylethan-1-one
CAS 717862-97-0C14H11F3N2OS
2-[(4-Methylpyrimidin-2-yl)sulfanyl]-1-(4-nitrophenyl)ethanone chemical structure, C13H11N3O3S, CAS 701239-60-3
2-[(4-Methylpyrimidin-2-yl)sulfanyl]-1-(4-nitrophenyl)ethanone
CAS 701239-60-3C13H11N3O3S
2-({2-Oxo-2-[3-(trifluoromethyl)phenyl]ethyl}sulfanyl)-4-(trifluoromethyl)-5-pyrimidinecarbonitrile chemical structure, C15H7F6N3OS, CAS 400077-06-7
2-({2-Oxo-2-[3-(trifluoromethyl)phenyl]ethyl}sulfanyl)-4-(trifluoromethyl)-5-pyrimidinecarbonitrile
CAS 400077-06-7C15H7F6N3OS
1-(4-Fluorophenyl)-2-(pyrimidin-2-ylthio)ethan-1-one chemical structure, C12H9FN2OS, CAS 380550-09-4
1-(4-Fluorophenyl)-2-(pyrimidin-2-ylthio)ethan-1-one
CAS 380550-09-4C12H9FN2OS
1-(2-Bromophenyl)-2-(pyrimidin-2-ylthio)ethan-1-one chemical structure, C12H9BrN2OS, CAS 721432-30-0
1-(2-Bromophenyl)-2-(pyrimidin-2-ylthio)ethan-1-one
CAS 721432-30-0C12H9BrN2OS
1-(2-Bromophenyl)-2-((4-methylpyrimidin-2-yl)thio)ethan-1-one chemical structure, C13H11BrN2OS, CAS 721891-90-3
1-(2-Bromophenyl)-2-((4-methylpyrimidin-2-yl)thio)ethan-1-one
CAS 721891-90-3C13H11BrN2OS
2-[(2-Oxo-2-phenylethyl)sulfanyl]-4-(trifluoromethyl)-5-pyrimidinecarbonitrile chemical structure, C14H8F3N3OS, CAS 303152-00-3
2-[(2-Oxo-2-phenylethyl)sulfanyl]-4-(trifluoromethyl)-5-pyrimidinecarbonitrile
CAS 303152-00-3C14H8F3N3OS
1-(2,4-Dichlorophenyl)-2-(pyrimidin-2-ylsulfanyl)ethanone chemical structure, C12H8Cl2N2OS, CAS 400737-32-8
1-(2,4-Dichlorophenyl)-2-(pyrimidin-2-ylsulfanyl)ethanone
CAS 400737-32-8C12H8Cl2N2OS
2-({2-Oxo-2-[4-(trifluoromethyl)phenyl]ethyl}sulfanyl)-4-(trifluoromethyl)-5-pyrimidinecarbonitrile chemical structure, C15H7F6N3OS, CAS 400079-37-0
2-({2-Oxo-2-[4-(trifluoromethyl)phenyl]ethyl}sulfanyl)-4-(trifluoromethyl)-5-pyrimidinecarbonitrile
CAS 400079-37-0C15H7F6N3OS
1-(4-Bromophenyl)-2-(pyrimidin-2-ylthio)ethanone chemical structure, C12H9BrN2OS, CAS 392719-46-9
1-(4-Bromophenyl)-2-(pyrimidin-2-ylthio)ethanone
CAS 392719-46-9C12H9BrN2OS