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Murcko scaffold

Ring system with 2 rings and 17 atoms

16 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
17
Chemicals
16
With full pages
3
Scaffold SMILES

O=C(CSc1ccncn1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ccncn1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

2-(2-Amino-5-cyano-6-methylsulfanylpyrimidin-4-yl)sulfanyl-N-(3-fluorophenyl)acetamide chemical structure, C14H12FN5OS2, CAS 340808-55-1
2-(2-Amino-5-cyano-6-methylsulfanylpyrimidin-4-yl)sulfanyl-N-(3-fluorophenyl)acetamide
CAS 340808-55-1C14H12FN5OS2
2-(2-Amino-5-cyano-6-methylsulfanylpyrimidin-4-yl)sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C15H12F3N5OS2, CAS 339156-77-3
2-(2-Amino-5-cyano-6-methylsulfanylpyrimidin-4-yl)sulfanyl-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 339156-77-3C15H12F3N5OS2
2-(6-Methyl-2-methylsulfanylpyrimidin-4-yl)sulfanyl-3-oxo-N-phenylbutanamide chemical structure, C16H17N3O2S2, CAS 370855-26-8
2-(6-Methyl-2-methylsulfanylpyrimidin-4-yl)sulfanyl-3-oxo-N-phenylbutanamide
CAS 370855-26-8C16H17N3O2S2
2-((2,6-Dimethyl-4-pyrimidinyl)thio)-N-(2-methylphenyl)acetamide chemical structure, C15H17N3OS, CAS 861139-17-5
2-((2,6-Dimethyl-4-pyrimidinyl)thio)-N-(2-methylphenyl)acetamide
CAS 861139-17-5C15H17N3OS
N-(3-Hydroxyphenyl)-2-(6-methylpyrimidin-4-yl)sulfanylpropanamide chemical structure, C14H15N3O2S, CAS 919666-09-4
N-(3-Hydroxyphenyl)-2-(6-methylpyrimidin-4-yl)sulfanylpropanamide
CAS 919666-09-4C14H15N3O2S
N-(3-Chloro-2-methylphenyl)-2-(pyrimidin-4-ylthio)acetamide chemical structure, C13H12ClN3OS, CAS 1226429-01-1
N-(3-Chloro-2-methylphenyl)-2-(pyrimidin-4-ylthio)acetamide
CAS 1226429-01-1C13H12ClN3OS
N-(3-Fluoro-4-methylphenyl)-2-(pyrimidin-4-ylthio)acetamide chemical structure, C13H12FN3OS, CAS 1226443-04-4
N-(3-Fluoro-4-methylphenyl)-2-(pyrimidin-4-ylthio)acetamide
CAS 1226443-04-4C13H12FN3OS
N-(3-Fluorophenyl)-2-((6-methylpyrimidin-4-yl)thio)acetamide chemical structure, C13H12FN3OS, CAS 1251624-77-7
N-(3-Fluorophenyl)-2-((6-methylpyrimidin-4-yl)thio)acetamide
CAS 1251624-77-7C13H12FN3OS
N-(2-Methoxy-5-(trifluoromethyl)phenyl)-2-(pyrimidin-4-ylthio)acetamide chemical structure, C14H12F3N3O2S, CAS 1226459-65-9
N-(2-Methoxy-5-(trifluoromethyl)phenyl)-2-(pyrimidin-4-ylthio)acetamide
CAS 1226459-65-9C14H12F3N3O2S
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((6-methylpyrimidin-4-yl)thio)acetamide chemical structure, C14H11ClF3N3OS, CAS 1251578-98-9
N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((6-methylpyrimidin-4-yl)thio)acetamide
CAS 1251578-98-9C14H11ClF3N3OS
N-(5-Chloro-2-methoxyphenyl)-2-((6-isopropylpyrimidin-4-yl)thio)acetamide chemical structure, C16H18ClN3O2S, CAS 1226456-19-4
N-(5-Chloro-2-methoxyphenyl)-2-((6-isopropylpyrimidin-4-yl)thio)acetamide
CAS 1226456-19-4C16H18ClN3O2S
N-(2-Methoxy-5-methylphenyl)-2-((6-propylpyrimidin-4-yl)thio)acetamide chemical structure, C17H21N3O2S, CAS 1226432-14-9
N-(2-Methoxy-5-methylphenyl)-2-((6-propylpyrimidin-4-yl)thio)acetamide
CAS 1226432-14-9C17H21N3O2S
N-(3-Chloro-2-methylphenyl)-2-((6-propylpyrimidin-4-yl)thio)acetamide chemical structure, C16H18ClN3OS, CAS 1226438-00-1
N-(3-Chloro-2-methylphenyl)-2-((6-propylpyrimidin-4-yl)thio)acetamide
CAS 1226438-00-1C16H18ClN3OS
2-((6-Propylpyrimidin-4-yl)thio)-N-(2-(trifluoromethyl)phenyl)acetamide chemical structure, C16H16F3N3OS, CAS 1226449-50-8
2-((6-Propylpyrimidin-4-yl)thio)-N-(2-(trifluoromethyl)phenyl)acetamide
CAS 1226449-50-8C16H16F3N3OS
N-(3-Hydroxyphenyl)-2-[(6-methylpyrimidin-4-yl)sulfanyl]acetamide chemical structure, C13H13N3O2S, CAS 1393593-08-2
N-(3-Hydroxyphenyl)-2-[(6-methylpyrimidin-4-yl)sulfanyl]acetamide
CAS 1393593-08-2C13H13N3O2S
N-(3-Ethoxyphenyl)-2-[(6-methylpyrimidin-4-yl)sulfanyl]acetamide chemical structure, C15H17N3O2S, CAS 1393591-79-1
N-(3-Ethoxyphenyl)-2-[(6-methylpyrimidin-4-yl)sulfanyl]acetamide
CAS 1393591-79-1C15H17N3O2S