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Murcko scaffold

Ring system with 4 rings and 25 atoms

110 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 110
With full pages: 1

Scaffold SMILES

O=C1N=C(N2CCN(c3ccccc3)CC2)SC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1N=C(N2CCN(c3ccccc3)CC2)SC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 110 chemicals

(E)-5-Benzylidene-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one chemical structure, C20H19N3OS, CAS 304889-84-7

(E)-5-Benzylidene-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one

CAS 304889-84-7C₂₀H₁₉N₃OS

(5E)-2-[4-(4-Chlorophenyl)piperazin-1-yl]-5-(2-ethoxybenzylidene)-1,3-thiazol-4(5H)-one chemical structure, C22H22ClN3O2S, CAS 370854-70-9

(5E)-2-[4-(4-Chlorophenyl)piperazin-1-yl]-5-(2-ethoxybenzylidene)-1,3-thiazol-4(5H)-one

CAS 370854-70-9C₂₂H₂₂ClN₃O₂S

(5E)-2-[4-(4-Chlorophenyl)piperazin-1-yl]-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazol-4-one chemical structure, C22H22ClN3O2S, CAS 371924-53-7

(5E)-2-[4-(4-Chlorophenyl)piperazin-1-yl]-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazol-4-one

CAS 371924-53-7C₂₂H₂₂ClN₃O₂S

(5E)-5-(4-Ethoxybenzylidene)-2-[4-(2-methylphenyl)piperazin-1-yl]-1,3-thiazol-4(5H)-one chemical structure, C23H25N3O2S, CAS 371119-33-4

(5E)-5-(4-Ethoxybenzylidene)-2-[4-(2-methylphenyl)piperazin-1-yl]-1,3-thiazol-4(5H)-one

CAS 371119-33-4C₂₃H₂₅N₃O₂S

(5E)-5-[(4-Ethoxyphenyl)methylidene]-2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-4-one chemical structure, C23H25N3O2S, CAS 371116-53-9

(5E)-5-[(4-Ethoxyphenyl)methylidene]-2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-4-one

CAS 371116-53-9C₂₃H₂₅N₃O₂S

(5E)-5-(2-Ethoxybenzylidene)-2-[4-(3-methylphenyl)piperazin-1-yl]-1,3-thiazol-4(5H)-one chemical structure, C23H25N3O2S, CAS 371219-50-0

(5E)-5-(2-Ethoxybenzylidene)-2-[4-(3-methylphenyl)piperazin-1-yl]-1,3-thiazol-4(5H)-one

CAS 371219-50-0C₂₃H₂₅N₃O₂S

(5E)-2-[4-(3-Chlorophenyl)piperazin-1-yl]-5-[(2-ethoxyphenyl)methylidene]-1,3-thiazol-4-one chemical structure, C22H22ClN3O2S, CAS 370870-98-7

(5E)-2-[4-(3-Chlorophenyl)piperazin-1-yl]-5-[(2-ethoxyphenyl)methylidene]-1,3-thiazol-4-one

CAS 370870-98-7C₂₂H₂₂ClN₃O₂S

(5Z)-2-[4-(2-Fluorophenyl)piperazin-1-yl]-5-(4-hydroxy-3-methoxybenzylidene)-1,3-thiazol-4(5H)-one chemical structure, C21H20FN3O3S, CAS 696619-15-5

(5Z)-2-[4-(2-Fluorophenyl)piperazin-1-yl]-5-(4-hydroxy-3-methoxybenzylidene)-1,3-thiazol-4(5H)-one

CAS 696619-15-5C₂₁H₂₀FN₃O₃S

(E)-5-(2-Ethoxybenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one chemical structure, C22H23N3O2S, CAS 370856-30-7

(E)-5-(2-Ethoxybenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one

CAS 370856-30-7C₂₂H₂₃N₃O₂S

(5E)-2-[4-(4-Chlorophenyl)piperazin-1-yl]-5-(4-hydroxybenzylidene)-1,3-thiazol-4(5H)-one chemical structure, C20H18ClN3O2S, CAS 6599-36-6

(5E)-2-[4-(4-Chlorophenyl)piperazin-1-yl]-5-(4-hydroxybenzylidene)-1,3-thiazol-4(5H)-one

CAS 6599-36-6C₂₀H₁₈ClN₃O₂S

(Z)-5-(4-Ethoxybenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one chemical structure, C22H23N3O2S, CAS 384369-28-2

(Z)-5-(4-Ethoxybenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one

CAS 384369-28-2C₂₂H₂₃N₃O₂S

5-[4-(Allyloxy)benzylidene]-2-(4-phenyl-1-piperazinyl)-1,3-thiazol-4(5H)-one chemical structure, C23H23N3O2S, CAS 374770-51-1

5-[4-(Allyloxy)benzylidene]-2-(4-phenyl-1-piperazinyl)-1,3-thiazol-4(5H)-one

CAS 374770-51-1C₂₃H₂₃N₃O₂S

(5Z)-5-[(4-Hydroxyphenyl)methylidene]-2-(4-phenylpiperazin-1-yl)-1,3-thiazol-4-one chemical structure, C20H19N3O2S, CAS 1253795-56-0

(5Z)-5-[(4-Hydroxyphenyl)methylidene]-2-(4-phenylpiperazin-1-yl)-1,3-thiazol-4-one

CAS 1253795-56-0C₂₀H₁₉N₃O₂S

(E)-5-(4-Hydroxybenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one chemical structure, C20H19N3O2S, CAS 1253795-62-8

(E)-5-(4-Hydroxybenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one

CAS 1253795-62-8C₂₀H₁₉N₃O₂S

(5Z)-5-[(2-Hydroxyphenyl)methylidene]-2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-4-one chemical structure, C21H21N3O2S, CAS 304889-88-1

(5Z)-5-[(2-Hydroxyphenyl)methylidene]-2-[4-(4-methylphenyl)piperazin-1-yl]-1,3-thiazol-4-one

CAS 304889-88-1C₂₁H₂₁N₃O₂S

(E)-5-(4-(Dimethylamino)benzylidene)-2-(4-(p-tolyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C23H26N4OS, CAS 304889-89-2

(E)-5-(4-(Dimethylamino)benzylidene)-2-(4-(p-tolyl)piperazin-1-yl)thiazol-4(5H)-one

CAS 304889-89-2C₂₃H₂₆N₄OS

(E)-5-(3-Nitrobenzylidene)-2-(4-(o-tolyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C21H20N4O3S, CAS 374922-75-5

(E)-5-(3-Nitrobenzylidene)-2-(4-(o-tolyl)piperazin-1-yl)thiazol-4(5H)-one

CAS 374922-75-5C₂₁H₂₀N₄O₃S

(E)-5-(3-Nitrobenzylidene)-2-(4-(p-tolyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C21H20N4O3S, CAS 375829-40-6

(E)-5-(3-Nitrobenzylidene)-2-(4-(p-tolyl)piperazin-1-yl)thiazol-4(5H)-one

CAS 375829-40-6C₂₁H₂₀N₄O₃S

(E)-5-(3-Nitrobenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one chemical structure, C20H18N4O3S, CAS 326097-24-9

(E)-5-(3-Nitrobenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one

CAS 326097-24-9C₂₀H₁₈N₄O₃S

(E)-5-(4-Hydroxy-3-nitrobenzylidene)-2-(4-(p-tolyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C21H20N4O4S, CAS 428858-46-2

(E)-5-(4-Hydroxy-3-nitrobenzylidene)-2-(4-(p-tolyl)piperazin-1-yl)thiazol-4(5H)-one

CAS 428858-46-2C₂₁H₂₀N₄O₄S

(E)-5-(4-Hydroxy-3-methoxybenzylidene)-2-(4-(o-tolyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C22H23N3O3S, CAS 840509-28-6

(E)-5-(4-Hydroxy-3-methoxybenzylidene)-2-(4-(o-tolyl)piperazin-1-yl)thiazol-4(5H)-one

CAS 840509-28-6C₂₂H₂₃N₃O₃S

(E)-5-(4-Hydroxy-3-nitrobenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one chemical structure, C20H18N4O4S, CAS 444051-21-2

(E)-5-(4-Hydroxy-3-nitrobenzylidene)-2-(4-phenylpiperazin-1-yl)thiazol-4(5H)-one

CAS 444051-21-2C₂₀H₁₈N₄O₄S

(5E)-2-[4-(3-Chloro-4-methylphenyl)piperazin-1-yl]-5-[(3-nitrophenyl)methylidene]-1,3-thiazol-4-one chemical structure, C21H19ClN4O3S, CAS 384356-22-3

(5E)-2-[4-(3-Chloro-4-methylphenyl)piperazin-1-yl]-5-[(3-nitrophenyl)methylidene]-1,3-thiazol-4-one

CAS 384356-22-3C₂₁H₁₉ClN₄O₃S

(E)-5-(4-Hydroxy-3-methoxybenzylidene)-2-(4-(m-tolyl)piperazin-1-yl)thiazol-4(5H)-one chemical structure, C22H23N3O3S, CAS 578756-99-7

(E)-5-(4-Hydroxy-3-methoxybenzylidene)-2-(4-(m-tolyl)piperazin-1-yl)thiazol-4(5H)-one

CAS 578756-99-7C₂₂H₂₃N₃O₃S