Murcko scaffold
Ring system with 3 rings and 25 atoms
81 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 25
- Chemicals
- 81
- With full pages
- 39
Scaffold SMILES
O=C(CN1CCN(Cc2ccccc2)CC1)NN=Cc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 81 chemicals
![4-(Phenylmethyl)-1-piperazineacetic acid 2-[(4-nitrophenyl)methylene]hydrazide chemical structure, C20H23N5O3, CAS 315183-22-3](/s/MFRIKINHQUTHII-UHFFFAOYSA-N.svg)
4-(Phenylmethyl)-1-piperazineacetic acid 2-[(4-nitrophenyl)methylene]hydrazide
CAS 315183-22-3C20H23N5O3
![2-(4-Benzylpiperazin-1-yl)-N'-[(E)-(2-methoxyphenyl)methylidene]acetohydrazide chemical structure, C21H26N4O2, CAS 315183-20-1](/s/FBARJBSLXDQMSW-JCMHNJIXSA-N.svg)
2-(4-Benzylpiperazin-1-yl)-N'-[(E)-(2-methoxyphenyl)methylidene]acetohydrazide
CAS 315183-20-1C21H26N4O2
![2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2-methoxyphenyl)methylidene]acetohydrazide chemical structure, C21H25ClN4O2, CAS 315198-58-4](/s/JOYTZSANRMPYQD-UCQKPKSFSA-N.svg)
2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2-methoxyphenyl)methylidene]acetohydrazide
CAS 315198-58-4C21H25ClN4O2
![2-(4-Benzylpiperazin-1-yl)-N'-[(E)-(5-bromo-2-methoxyphenyl)methylidene]acetohydrazide chemical structure, C21H25BrN4O2, CAS 315182-78-6](/s/MXNKLMLCCQMSHE-UCQKPKSFSA-N.svg)
2-(4-Benzylpiperazin-1-yl)-N'-[(E)-(5-bromo-2-methoxyphenyl)methylidene]acetohydrazide
CAS 315182-78-6C21H25BrN4O2
![N'-[(E)-(4-tert-Butylphenyl)methylidene]-2-[4-(2-chlorobenzyl)piperazin-1-yl]acetohydrazide chemical structure, C24H31ClN4O, CAS 315198-16-4](/s/RDTMEHXUAZBSQU-QQXSKIMKSA-N.svg)
N'-[(E)-(4-tert-Butylphenyl)methylidene]-2-[4-(2-chlorobenzyl)piperazin-1-yl]acetohydrazide
CAS 315198-16-4C24H31ClN4O
![2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2,4-dichlorophenyl)methylidene]acetohydrazide chemical structure, C20H21Cl3N4O, CAS 315198-50-6](/s/WJMATWDFIVOIPV-MSXFZWOLSA-N.svg)
2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2,4-dichlorophenyl)methylidene]acetohydrazide
CAS 315198-50-6C20H21Cl3N4O
![2-(4-Benzyl-1-piperazinyl)-N'-[(E)-(4-methoxyphenyl)methylidene]acetohydrazide chemical structure, C21H26N4O2, CAS 315183-07-4](/s/QQIVBXRWKHVREW-JCMHNJIXSA-N.svg)
2-(4-Benzyl-1-piperazinyl)-N'-[(E)-(4-methoxyphenyl)methylidene]acetohydrazide
CAS 315183-07-4C21H26N4O2
![2-[4-(2-Chlorobenzyl)-1-piperazinyl]-N'-[(E)-(4-chlorophenyl)methylidene]acetohydrazide chemical structure, C20H22Cl2N4O, CAS 315198-44-8](/s/RGZJMRMOBPRRID-QRVIBDJDSA-N.svg)
2-[4-(2-Chlorobenzyl)-1-piperazinyl]-N'-[(E)-(4-chlorophenyl)methylidene]acetohydrazide
CAS 315198-44-8C20H22Cl2N4O
2-(4-Benzyl-1-piperazinyl)-N'-(3-hydroxybenzylidene)acetohydrazide
CAS 315182-84-4C20H24N4O2
N'-(3-Bromobenzylidene)-2-(4-(2-chlorobenzyl)-1-piperazinyl)acetohydrazide
CAS 315186-22-2C20H22BrClN4O
![N'-[(E)-(5-Bromo-2-methoxyphenyl)methylidene]-2-[4-(2-chlorobenzyl)piperazin-1-yl]acetohydrazide chemical structure, C21H24BrClN4O2, CAS 315186-38-0](/s/RAUUODSVYQJIBP-CFRMEGHHSA-N.svg)
N'-[(E)-(5-Bromo-2-methoxyphenyl)methylidene]-2-[4-(2-chlorobenzyl)piperazin-1-yl]acetohydrazide
CAS 315186-38-0C21H24BrClN4O2
N'-(3-Chlorobenzylidene)-2-(4-(2-chlorobenzyl)-1-piperazinyl)acetohydrazide
CAS 315186-39-1C20H22Cl2N4O
![2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2-chloro-6-fluorophenyl)methylidene]acetohydrazide chemical structure, C20H21Cl2FN4O, CAS 315186-40-4](/s/MDVKWRACXCBFJR-MSXFZWOLSA-N.svg)
2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2-chloro-6-fluorophenyl)methylidene]acetohydrazide
CAS 315186-40-4C20H21Cl2FN4O
![2-[4-(2-Chlorobenzyl)-1-piperazinyl]-N'-[(E)-(4-fluorophenyl)methylidene]acetohydrazide chemical structure, C20H22ClFN4O, CAS 315186-47-1](/s/ZOAYLVIYOJXOBO-QRVIBDJDSA-N.svg)
2-[4-(2-Chlorobenzyl)-1-piperazinyl]-N'-[(E)-(4-fluorophenyl)methylidene]acetohydrazide
CAS 315186-47-1C20H22ClFN4O
![2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2,6-dichlorophenyl)methylidene]acetohydrazide chemical structure, C20H21Cl3N4O, CAS 315198-14-2](/s/IPWPYXOUVMJVKB-MSXFZWOLSA-N.svg)
2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2,6-dichlorophenyl)methylidene]acetohydrazide
CAS 315198-14-2C20H21Cl3N4O
![2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(3,4-dichlorophenyl)methylidene]acetohydrazide chemical structure, C20H21Cl3N4O, CAS 315198-19-7](/s/GQGHVPHSWNDLLH-MSXFZWOLSA-N.svg)
2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(3,4-dichlorophenyl)methylidene]acetohydrazide
CAS 315198-19-7C20H21Cl3N4O
2-(4-(2-CL-Benzyl)-1-piperazinyl)-N'-(4-(methylthio)benzylidene)acetohydrazide
CAS 315198-23-3C21H25ClN4OS
N'-Benzylidene-2-(4-(2-chlorobenzyl)-1-piperazinyl)acetohydrazide
CAS 315198-38-0C20H23ClN4O
N'-(2-Chlorobenzylidene)-2-(4-(2-chlorobenzyl)-1-piperazinyl)acetohydrazide
CAS 315198-45-9C20H22Cl2N4O
![2-[4-(2-Chlorobenzyl)-1-piperazinyl]-N'-[(E)-(4-methylphenyl)methylidene]acetohydrazide chemical structure, C21H25ClN4O, CAS 315198-54-0](/s/JBEOLGVPRQQFRL-UCQKPKSFSA-N.svg)
2-[4-(2-Chlorobenzyl)-1-piperazinyl]-N'-[(E)-(4-methylphenyl)methylidene]acetohydrazide
CAS 315198-54-0C21H25ClN4O
![2-{4-[(2-Chlorophenyl)methyl]piperazin-1-yl}-N'-[(Z)-[4-(propan-2-yl)phenyl]methylidene]acetohydrazide chemical structure, C23H29ClN4O, CAS 315198-63-1](/s/BGEDTDJORCKTPZ-MYYYXRDXSA-N.svg)
2-{4-[(2-Chlorophenyl)methyl]piperazin-1-yl}-N'-[(Z)-[4-(propan-2-yl)phenyl]methylidene]acetohydrazide
CAS 315198-63-1C23H29ClN4O
![2-(4-Benzyl-1-piperazinyl)-N'-[(E)-(3-bromophenyl)methylidene]acetohydrazide chemical structure, C20H23BrN4O, CAS 315182-64-0](/s/FZAMFKKVQSNMQD-HMAPJEAMSA-N.svg)
2-(4-Benzyl-1-piperazinyl)-N'-[(E)-(3-bromophenyl)methylidene]acetohydrazide
CAS 315182-64-0C20H23BrN4O
![2-(4-Benzyl-1-piperazinyl)-N'-[(E)-(3,4-dichlorophenyl)methylidene]acetohydrazide chemical structure, C20H22Cl2N4O, CAS 315182-93-5](/s/HZNYMHXOIATXMP-QRVIBDJDSA-N.svg)
2-(4-Benzyl-1-piperazinyl)-N'-[(E)-(3,4-dichlorophenyl)methylidene]acetohydrazide
CAS 315182-93-5C20H22Cl2N4O
2-(4-Benzyl-1-piperazinyl)-N'-(4-(methylthio)benzylidene)acetohydrazide
CAS 315182-95-7C21H26N4OS
- 2-(4-Benzyl-1-piperazinyl)-N'-[(E)-(4-chlorophenyl)methylidene]acetohydrazide315183-12-1C20H23ClN4O
- 2-(4-Benzyl-1-piperazinyl)-N'-[(E)-(4-tert-butylphenyl)methylidene]acetohydrazide315182-92-4C24H32N4O
- 2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2,5-dimethoxyphenyl)methylidene]acetohydrazide315186-43-7C22H27ClN4O3
- Methyl 4-[(E)-{2-[(4-benzylpiperazin-1-yl)acetyl]hydrazinylidene}methyl]benzoate315182-86-6C22H26N4O3
- 2-(4-Benzyl-1-piperazinyl)-N'-(1-(4-methoxyphenyl)ethylidene)acetohydrazide303103-82-4C22H28N4O2
- 2-(4-(2-CL-Benzyl)-1-piperazinyl)-N'-(4-(diethylamino)benzylidene)acetohydrazide315198-56-2C24H32ClN5O
- N'-[(1E)-1-(4-Bromophenyl)ethylidene]-2-[4-(2-chlorobenzyl)piperazin-1-yl]acetohydrazide315198-72-2C21H24BrClN4O
- 2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(3,4,5-trimethoxyphenyl)methylidene]acetohydrazide315186-50-6C23H29ClN4O4
- Methyl 4-[(E)-(2-{[4-(2-chlorobenzyl)piperazin-1-yl]acetyl}hydrazinylidene)methyl]benzoate315186-46-0C22H25ClN4O3
- 2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(1E)-1-(4-chlorophenyl)ethylidene]acetohydrazide315198-71-1C21H24Cl2N4O
- 2-[4-(2-Chlorobenzyl)piperazin-1-yl]-N'-[(E)-(2-ethoxyphenyl)methylidene]acetohydrazide315186-24-4C22H27ClN4O2
- 2-(4-(2-Chlorobenzyl)-1-piperazinyl)-N'-(3,4-dimethoxybenzylidene)acetohydrazide315198-62-0C22H27ClN4O3
- N'-[(Z)-(3-Hydroxyphenyl)methylidene]-2-[4-(4-methylbenzyl)piperazin-1-yl]acetohydrazide500147-33-1C21H26N4O2
- N-[(E)-(2-Fluorophenyl)methylideneamino]-2-[4-[(4-methylphenyl)methyl]piperazin-1-yl]acetamide489413-41-4C21H25FN4O
- 2-[4-(4-Methylbenzyl)piperazin-1-yl]-N'-{(Z)-[2-(trifluoromethyl)phenyl]methylidene}acetohydrazide499208-63-8C22H25F3N4O
- 2-(4-Benzyl-1-piperazinyl)-N'-(3-bromo-4-methoxybenzylidene)acetohydrazide303105-89-7C21H25BrN4O2
- N'-[(Z)-(2,3-Dichlorophenyl)methylidene]-2-[4-(4-methylbenzyl)piperazin-1-yl]acetohydrazide497242-92-9C21H24Cl2N4O
- 2-(4-Benzyl-1-piperazinyl)-N'-(2,4-dichlorobenzylidene)acetohydrazide303107-53-1C20H22Cl2N4O
- 2-(4-Benzyl-1-piperazinyl)-N'-(3-fluorobenzylidene)acetohydrazide303103-72-2C20H23FN4O
- 2-(4-(2-Chlorobenzyl)-1-piperazinyl)-N'-(4-methoxybenzylidene)acetohydrazide315198-39-1C21H25ClN4O2
- 2-[4-[(4-Chlorophenyl)methyl]piperazin-1-yl]-N-[(E)-(3-fluorophenyl)methylideneamino]acetamide487032-53-1C20H22ClFN4O
- 2-(4-Benzylpiperazin-1-yl)-N-[(E)-(2-fluorophenyl)methylideneamino]acetamide315182-70-8C20H23FN4O
- 2-(4-Benzyl-1-piperazinyl)-N'-(4-isopropylbenzylidene)acetohydrazide303107-55-3C23H30N4O
- 2-(4-(2-CL-Benzyl)-1-piperazinyl)N'-(4-(dimethylamino)benzylidene)acetohydrazide315198-42-6C22H28ClN5O
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(NCCS(=O)(=O)N1CCN(Cc2ccccc2)CC1)c1ccccc13 chemicals
O=C(CN1CCN(Cc2ccccc2)CC1)NCCc1ccccc13 chemicals
O=C(COC(=O)c1ccc(S(=O)(=O)N2CCOCC2)cc1)Nc1ccccc12 chemicals
O=C(CN1CCN(Cc2ccccc2)CC1)NN=Cc1cccnc12 chemicals
O=C(NCCC(=O)N1CCN(Cc2ccccc2)CC1)c1ccccc12 chemicals
O=C(COC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1)Nc1ccccc12 chemicals
O=C(OCCCc1ccncc1)c1ccc(S(=O)(=O)N2CCOCC2)cc11 chemical
O=C(CN1CCN(S(=O)(=O)c2ccccc2)CC1)NN=Cc1ccncc11 chemical![Scaffold O=c1[nH]c(NCCCCc2ccccn2)ncc1Cc1cccnc1](/scaffold/AXUFKQJZOZCGDE-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(NCCCCc2ccccn2)ncc1Cc1cccnc11 chemical
O=C(CCS(=O)(=O)Cc1ccccc1)N1CCN(Cc2ccccc2)CC11 chemical
S=C(NCCN1CCOCC1)Nc1ccc(Nc2ccccc2)cc11 chemical![Scaffold O=C(CSc1ncc(S(=O)(=O)c2ccccc2)c(=O)[nH]1)NCc1ccccc1](/scaffold/DNPFKPLUJSVXSD-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc(S(=O)(=O)c2ccccc2)c(=O)[nH]1)NCc1ccccc11 chemical