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Murcko scaffold

Ring system with 3 rings and 28 atoms

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
28
Chemicals
18
With full pages
1
Scaffold SMILES

O=C(CSc1ncc(S(=O)(=O)c2ccccc2)c(=O)[nH]1)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1ncc(S(=O)(=O)c2ccccc2)c(=O)[nH]1)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-((5-((4-Bromophenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(3-methoxybenzyl)acetamide chemical structure, C20H18BrN3O5S2, CAS 899548-36-8
2-((5-((4-Bromophenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(3-methoxybenzyl)acetamide
CAS 899548-36-8C20H18BrN3O5S2
2-{[5-(3-Chloro-4-methylbenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(4-methoxyphenyl)methyl]acetamide chemical structure, C21H20ClN3O5S2, CAS 932973-83-6
2-{[5-(3-Chloro-4-methylbenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(4-methoxyphenyl)methyl]acetamide
CAS 932973-83-6C21H20ClN3O5S2
2-((5-((4-(tert-Butyl)phenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-chlorobenzyl)acetamide chemical structure, C23H24ClN3O4S2, CAS 893790-11-9
2-((5-((4-(tert-Butyl)phenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-chlorobenzyl)acetamide
CAS 893790-11-9C23H24ClN3O4S2
2-((5-((4-(tert-Butyl)phenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-fluorobenzyl)acetamide chemical structure, C23H24FN3O4S2, CAS 899725-25-8
2-((5-((4-(tert-Butyl)phenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-fluorobenzyl)acetamide
CAS 899725-25-8C23H24FN3O4S2
N-[(4-Chlorophenyl)methyl]-2-{[5-(4-methoxybenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}acetamide chemical structure, C20H18ClN3O5S2, CAS 1021263-86-4
N-[(4-Chlorophenyl)methyl]-2-{[5-(4-methoxybenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}acetamide
CAS 1021263-86-4C20H18ClN3O5S2
2-{[5-(3,4-Dimethoxybenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(4-fluorophenyl)methyl]acetamide chemical structure, C21H20FN3O6S2, CAS 1021263-90-0
2-{[5-(3,4-Dimethoxybenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(4-fluorophenyl)methyl]acetamide
CAS 1021263-90-0C21H20FN3O6S2
2-{[5-(4-Butylbenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(4-methylphenyl)methyl]acetamide chemical structure, C24H27N3O4S2, CAS 1021261-24-4
2-{[5-(4-Butylbenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(4-methylphenyl)methyl]acetamide
CAS 1021261-24-4C24H27N3O4S2
2-{[5-(4-Butylbenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(4-fluorophenyl)methyl]acetamide chemical structure, C23H24FN3O4S2, CAS 1021223-98-2
2-{[5-(4-Butylbenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(4-fluorophenyl)methyl]acetamide
CAS 1021223-98-2C23H24FN3O4S2
2-{[5-(4-Ethoxybenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(3-methoxyphenyl)methyl]acetamide chemical structure, C22H23N3O6S2, CAS 1021258-13-8
2-{[5-(4-Ethoxybenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}-N-[(3-methoxyphenyl)methyl]acetamide
CAS 1021258-13-8C22H23N3O6S2
N-Benzyl-2-{[5-(4-ethoxybenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}acetamide chemical structure, C21H21N3O5S2, CAS 1021220-85-8
N-Benzyl-2-{[5-(4-ethoxybenzenesulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl]sulfanyl}acetamide
CAS 1021220-85-8C21H21N3O5S2
N-Benzyl-2-((5-((4-ethylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C21H21N3O4S2, CAS 1021264-77-6
N-Benzyl-2-((5-((4-ethylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 1021264-77-6C21H21N3O4S2
N-Benzyl-2-((5-((3-chloro-4-methylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C20H18ClN3O4S2, CAS 946270-35-5
N-Benzyl-2-((5-((3-chloro-4-methylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 946270-35-5C20H18ClN3O4S2
N-(4-Chlorobenzyl)-2-((5-((3,4-dimethoxyphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide chemical structure, C21H20ClN3O6S2, CAS 1223977-83-0
N-(4-Chlorobenzyl)-2-((5-((3,4-dimethoxyphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
CAS 1223977-83-0C21H20ClN3O6S2
2-((5-((4-Butylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-chlorobenzyl)acetamide chemical structure, C23H24ClN3O4S2, CAS 1223800-51-8
2-((5-((4-Butylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-chlorobenzyl)acetamide
CAS 1223800-51-8C23H24ClN3O4S2
2-((5-((4-Butylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-methoxybenzyl)acetamide chemical structure, C24H27N3O5S2, CAS 1223902-49-5
2-((5-((4-Butylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-methoxybenzyl)acetamide
CAS 1223902-49-5C24H27N3O5S2
2-((5-((4-Butylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(3-methoxybenzyl)acetamide chemical structure, C24H27N3O5S2, CAS 1223853-98-2
2-((5-((4-Butylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(3-methoxybenzyl)acetamide
CAS 1223853-98-2C24H27N3O5S2
2-({5-[(4-Butylphenyl)sulfonyl]-6-oxo-1,6-dihydropyrimidin-2-yl}sulfanyl)-N-(2-methoxybenzyl)acetamide chemical structure, C24H27N3O5S2, CAS 1223930-81-1
2-({5-[(4-Butylphenyl)sulfonyl]-6-oxo-1,6-dihydropyrimidin-2-yl}sulfanyl)-N-(2-methoxybenzyl)acetamide
CAS 1223930-81-1C24H27N3O5S2
2-((5-((4-Butylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(2-chlorobenzyl)acetamide chemical structure, C23H24ClN3O4S2, CAS 1223788-20-2
2-((5-((4-Butylphenyl)sulfonyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(2-chlorobenzyl)acetamide
CAS 1223788-20-2C23H24ClN3O4S2