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Murcko scaffold

Ring system with 4 rings and 12 atoms

47 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
12
Chemicals
47
With full pages
8
Scaffold SMILES

c1ccc(C23COC(C2)C3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C23COC(C2)C3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

4-(2-Methylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H14O3, CAS 2168662-66-4
4-(2-Methylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2168662-66-4C13H14O3
4-(3-Fluorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C12H11FO3, CAS 2169139-23-3
4-(3-Fluorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2169139-23-3C12H11FO3
4-Phenyl-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C12H12O3, CAS 2167002-19-7
4-Phenyl-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2167002-19-7C12H12O3
1-(Iodomethyl)-4-phenyl-2-oxabicyclo(2.1.1)hexane chemical structure, C12H13IO, CAS 2378502-94-2
1-(Iodomethyl)-4-phenyl-2-oxabicyclo(2.1.1)hexane
CAS 2378502-94-2C12H13IO
4-Phenyl-2-oxabicyclo(2.1.1)hexane-1-carboxylic acid chemical structure, C12H12O3, CAS 2613383-83-6
4-Phenyl-2-oxabicyclo(2.1.1)hexane-1-carboxylic acid
CAS 2613383-83-6C12H12O3
{4-Phenyl-2-oxabicyclo[2.1.1]hexan-1-yl}methanol chemical structure, C12H14O2, CAS 2384500-49-4
{4-Phenyl-2-oxabicyclo[2.1.1]hexan-1-yl}methanol
CAS 2384500-49-4C12H14O2
1-{4-Phenyl-2-oxabicyclo[2.1.1]hexan-1-yl}methanamine hydrochloride chemical structure, C12H16ClNO, CAS 2613383-35-8
1-{4-Phenyl-2-oxabicyclo[2.1.1]hexan-1-yl}methanamine hydrochloride
CAS 2613383-35-8C12H16ClNO
1-{4-Phenyl-2-oxabicyclo[2.1.1]hexan-1-yl}methanamine chemical structure, C12H15NO, CAS 2167438-92-6
1-{4-Phenyl-2-oxabicyclo[2.1.1]hexan-1-yl}methanamine
CAS 2167438-92-6C12H15NO
4-(2-Fluorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C12H11FO3, CAS 2168434-70-4
4-(2-Fluorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2168434-70-4C12H11FO3
Rel-(1R,4S,5S)-4-phenyl-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C12H12O3, CAS 2759497-30-6
Rel-(1R,4S,5S)-4-phenyl-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2759497-30-6C12H12O3
Methyl 4-phenyl-2-oxabicyclo[2.1.1]hexane-5-carboxylate chemical structure, C13H14O3, CAS 2386095-47-0
Methyl 4-phenyl-2-oxabicyclo[2.1.1]hexane-5-carboxylate
CAS 2386095-47-0C13H14O3
4-(3,4,5-Trifluorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C12H9F3O3, CAS 2770557-68-9
4-(3,4,5-Trifluorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2770557-68-9C12H9F3O3
Methyl 4-(4-chlorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylate chemical structure, C13H13ClO3, CAS 2770358-96-6
Methyl 4-(4-chlorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylate
CAS 2770358-96-6C13H13ClO3
4-[3-(Trifluoromethyl)phenyl]-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H11F3O3, CAS 2770546-74-0
4-[3-(Trifluoromethyl)phenyl]-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2770546-74-0C13H11F3O3
4-(3-tert-Butylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C16H20O3, CAS 2770494-97-6
4-(3-tert-Butylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2770494-97-6C16H20O3
4-(3-Methoxyphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H14O4, CAS 2172139-82-9
4-(3-Methoxyphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2172139-82-9C13H14O4
4-(4-Fluorophenyl)-2-oxabicyclo(2.1.1)hexane-5-carboxylic acid chemical structure, C12H11FO3, CAS 2168092-65-5
4-(4-Fluorophenyl)-2-oxabicyclo(2.1.1)hexane-5-carboxylic acid
CAS 2168092-65-5C12H11FO3
4-(2-Chlorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C12H11ClO3, CAS 2168221-84-7
4-(2-Chlorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2168221-84-7C12H11ClO3
4-(4-Methylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H14O3, CAS 2166681-57-6
4-(4-Methylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2166681-57-6C13H14O3
4-(4-Chlorophenyl)-2-oxabicyclo(2.1.1)hexane-5-carboxylic acid chemical structure, C12H11ClO3, CAS 2167364-89-6
4-(4-Chlorophenyl)-2-oxabicyclo(2.1.1)hexane-5-carboxylic acid
CAS 2167364-89-6C12H11ClO3
4-(3-Chlorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C12H11ClO3, CAS 2167991-21-9
4-(3-Chlorophenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2167991-21-9C12H11ClO3
4-(4-(Trifluoromethyl)phenyl)-2-oxabicyclo(2.1.1)hexane-5-carboxylic acid chemical structure, C13H11F3O3, CAS 2728257-83-6
4-(4-(Trifluoromethyl)phenyl)-2-oxabicyclo(2.1.1)hexane-5-carboxylic acid
CAS 2728257-83-6C13H11F3O3
4-(3-Methylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H14O3, CAS 2169208-80-2
4-(3-Methylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2169208-80-2C13H14O3
rac-(1R,4S,5S)-4-(2-Methylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylicacid chemical structure, C13H14O3, CAS 2763588-77-6
rac-(1R,4S,5S)-4-(2-Methylphenyl)-2-oxabicyclo[2.1.1]hexane-5-carboxylicacid
CAS 2763588-77-6C13H14O3