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Murcko scaffold

Ring system with 4 rings and 12 atoms

136 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
12
Chemicals
136
With full pages
6
Scaffold SMILES

c1ccc(C23CCC(C2)C3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C23CCC(C2)C3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 136 chemicals

1-Phenylbicyclo[2.1.1]hexan-2-ol chemical structure, C12H14O, CAS 1823678-19-8
1-Phenylbicyclo[2.1.1]hexan-2-ol
CAS 1823678-19-8C12H14O
1-Phenylbicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H14O2, CAS 2126163-33-3
1-Phenylbicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2126163-33-3C13H14O2
4-Phenylbicyclo(2.1.1)hexane-1-carboxylic acid chemical structure, C13H14O2, CAS 2167179-03-3
4-Phenylbicyclo(2.1.1)hexane-1-carboxylic acid
CAS 2167179-03-3C13H14O2
(1R,4R,5R)-1-Phenylbicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H14O2, CAS 2307783-97-5
(1R,4R,5R)-1-Phenylbicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2307783-97-5C13H14O2
1-(4-Fluorophenyl)bicyclo(2.1.1)hexane-5-carboxylic acid chemical structure, C13H13FO2, CAS 2166803-75-2
1-(4-Fluorophenyl)bicyclo(2.1.1)hexane-5-carboxylic acid
CAS 2166803-75-2C13H13FO2
1-(4-Methoxyphenyl)bicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C14H16O3, CAS 2172238-38-7
1-(4-Methoxyphenyl)bicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2172238-38-7C14H16O3
(1R,4R,5R)-1-(4-(Trifluoromethyl)phenyl)bicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C14H13F3O2, CAS 2307771-86-2
(1R,4R,5R)-1-(4-(Trifluoromethyl)phenyl)bicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2307771-86-2C14H13F3O2
rac-(1R,4R,5R)-1-(3-Bromophenyl)bicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H13BrO2, CAS 2230807-20-0
rac-(1R,4R,5R)-1-(3-Bromophenyl)bicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2230807-20-0C13H13BrO2
rac-(1R,4R,5R)-1-(4-Bromophenyl)bicyclo(2.1.1)hexane-5-carboxylic acid chemical structure, C13H13BrO2, CAS 2230799-52-5
rac-(1R,4R,5R)-1-(4-Bromophenyl)bicyclo(2.1.1)hexane-5-carboxylic acid
CAS 2230799-52-5C13H13BrO2
rac-(1R,4R,5R)-1-(4-Chlorophenyl)bicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H13ClO2, CAS 2287248-42-2
rac-(1R,4R,5R)-1-(4-Chlorophenyl)bicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2287248-42-2C13H13ClO2
rac-(1R,4R,5R)-1-(3,4,5-Trifluorophenyl)bicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C13H11F3O2, CAS 2413848-16-3
rac-(1R,4R,5R)-1-(3,4,5-Trifluorophenyl)bicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2413848-16-3C13H11F3O2
1-(4-(Trifluoromethyl)phenyl)bicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C14H13F3O2, CAS 2219380-08-0
1-(4-(Trifluoromethyl)phenyl)bicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2219380-08-0C14H13F3O2
Rel-(1R,4R,5S)-1-(4-(trifluoromethyl)phenyl)bicyclo[2.1.1]hexane-5-carboxylic acid chemical structure, C14H13F3O2, CAS 2565557-55-1
Rel-(1R,4R,5S)-1-(4-(trifluoromethyl)phenyl)bicyclo[2.1.1]hexane-5-carboxylic acid
CAS 2565557-55-1C14H13F3O2
4-(2-Methylphenyl)bicyclo[2.1.1]hexane-1-carboxylic acid chemical structure, C14H16O2, CAS 2168864-95-5
4-(2-Methylphenyl)bicyclo[2.1.1]hexane-1-carboxylic acid
CAS 2168864-95-5C14H16O2
5-(Chloromethyl)-1-phenylbicyclo[2.1.1]hexane chemical structure, C13H15Cl, CAS 2138136-92-0
5-(Chloromethyl)-1-phenylbicyclo[2.1.1]hexane
CAS 2138136-92-0C13H15Cl
1-Phenylbicyclo[2.1.1]hexan-5-amine chemical structure, C12H15N, CAS 2137610-44-5
1-Phenylbicyclo[2.1.1]hexan-5-amine
CAS 2137610-44-5C12H15N
1-(4-Fluorophenyl)bicyclo[2.1.1]hexan-5-amine chemical structure, C12H14FN, CAS 2137794-61-5
1-(4-Fluorophenyl)bicyclo[2.1.1]hexan-5-amine
CAS 2137794-61-5C12H14FN
1-(2-Methoxyphenyl)bicyclo[2.1.1]hexan-5-amine chemical structure, C13H17NO, CAS 2138244-83-2
1-(2-Methoxyphenyl)bicyclo[2.1.1]hexan-5-amine
CAS 2138244-83-2C13H17NO
1-(4-Methoxyphenyl)-N-methylbicyclo[2.1.1]hexan-5-amine chemical structure, C14H19NO, CAS 2138244-97-8
1-(4-Methoxyphenyl)-N-methylbicyclo[2.1.1]hexan-5-amine
CAS 2138244-97-8C14H19NO
N-Methyl-1-(2-methylphenyl)bicyclo[2.1.1]hexan-5-amine chemical structure, C14H19N, CAS 2138230-92-7
N-Methyl-1-(2-methylphenyl)bicyclo[2.1.1]hexan-5-amine
CAS 2138230-92-7C14H19N
N-Methyl-1-(3-methylphenyl)bicyclo[2.1.1]hexan-5-amine chemical structure, C14H19N, CAS 2138139-15-6
N-Methyl-1-(3-methylphenyl)bicyclo[2.1.1]hexan-5-amine
CAS 2138139-15-6C14H19N
1-(4-Fluorophenyl)bicyclo[2.1.1]hexan-5-ol chemical structure, C12H13FO, CAS 2138245-00-6
1-(4-Fluorophenyl)bicyclo[2.1.1]hexan-5-ol
CAS 2138245-00-6C12H13FO
1-(2-Methoxyphenyl)bicyclo[2.1.1]hexan-5-ol chemical structure, C13H16O2, CAS 2138245-17-5
1-(2-Methoxyphenyl)bicyclo[2.1.1]hexan-5-ol
CAS 2138245-17-5C13H16O2
{1-Phenylbicyclo[2.1.1]hexan-5-yl}methanol chemical structure, C13H16O, CAS 2138183-74-9
{1-Phenylbicyclo[2.1.1]hexan-5-yl}methanol
CAS 2138183-74-9C13H16O